High Blood Pressure:
Research has linked Gotu Kola with a decrease in many diseases like congestive heart failure, and one of the positive associations with the herb was blood pressure. Gotu Kola is able to regulate blood pressure and reduce strain on the cardiovascular system by relieving anxiety and tension in the arteries and blood vessels. This protects the heart and prevents diseases like heart attacks, stroke, and atherosclerosis from occurring.
Gotu Kola actually plays two important roles in the circulatory system, both of which benefit our bodies. Firstly, the plant extract can protect and strengthen the walls of blood vessels and capillaries, which prevents blood leakage and optimizes the circulatory system. Secondly, it stimulates the flow of blood, which increases oxygenation in different parts of the body and important organ systems. This also alleviates problems caused due to poor blood circulation such as swelling, leg heaviness, and pain. The strengthened blood vessels and capillaries aids in accomplishing proper blood circulation, and in turn reduce the chances of thrombosis as well as regulate the blood pressure. This also diminishes the risk of heart attack, stroke, and atherosclerosis.
These effects are believed to be linked to chemical compounds known as triterpenes, which stimulate the production of cardiac glycosides. Cardiac glycosides are organic compounds that increase the force of the heart and increase the rate of the heart's contractions. There is some evidence that Gotu Kola may stabilize fatty plaques in blood vessels, preventing them from breaking off. This is important because maintaining optimal brain circulation is one of the most important things you can do to keep your brain healthy and fit.
In 2001, the research found that Gotu Kola effectively reduces fluid retention problems, circulation, and ankle swelling caused after taking flight for more than three hours.
Centellase, a chemical compound found in Gotu Kola, has been found to help reduce swelling and improve circulation in the legs of people suffering from circulation problems. Gotu Kola protects and strengthens the walls of blood vessels and capillaries while stimulating blood flow. It optimizes the circulatory system and provides oxygen to various parts of the body to prevent swelling, heaviness in the feet and pain. It prevents blood clotting. Because of this, it is also believed that Gotu Kola can help with reducing blood clots, but more research needs to be done in order to confirm this claim.
Centella asiatica has a positive effect on cardiovascular diseases. The main components that affect the cardiovascular system are asiaticoside and asiatic acid. hypertension and atherosclerosis are the mostly studied diseases in involved articles.
Mix the ingredients: Centella leaves, Walnut, Badam, Cardamom, Pepper. Powder it and eat it with sugar candy on early mornings will cure the severity of heart diseases.
The chemical compound called Triterpenes is linked to chronic insufficiency effects of Gotu Kola. Triterpenes in Pennywort induce cardiac glycosides (organic compounds) production that increases heart force and contraction rate. A study in Malaysia in 2013 has proved it also.
Hypoxic pulmonary hypertension can cause pulmonary arterial changes, including pulmonary arterial stiffness and narrowing. Ventricular changes caused by right ventricular hypertrophy and right ventricular fibrosis affect ventricular function. Renovascular hypertension is one of the common causes of secondary hypertension. About 90% of cases are due to atherosclerotic renal artery stenosis and often accompanied by severe occlusive diseases of other blood vessels, accounting for poor prognosis. The Ang II/AT1R signaling pathway can regulate a series of intracellular pathways to improve cardiac insufficiency and myocardial remodeling, which is closely associated with the occurrence and development of renal hypertension. The transverse aortic constriction contributes to the occurrence of cardiac hypertrophy and failure. The common pathological changes are systolic dysfunction and cardiac fibrosis of the heart. Pressure overload triggers the expression of inflammation genes. Inhibiting early inflammation reactions can reduce cardiac remodeling and improve heart function.
Fibrosis is a pivotal player in the development and progression of heart failure, which is controlled by the TGF-β/Smads pathway. Smad2 and Smad3 are the two main downstream regulators of TGF-β1-mediated tissue fibrosis, and Smad7 is a negative feedback regulator. Cardiovascular diseases can cause a variety of pathological changes and affect the development of related pathology by affecting Ang II/AT1R and TGF-β/Smads signaling pathways.
Wang X. B. et al. found that asiaticoside reduced mean pulmonary artery pressure and right ventricular hypertrophy by inhibiting the overexpressed TGF-β1/Smad2/3 signaling pathway in the hypoxia-induced pulmonary hypertension rat model. In 2017 they further confirmed that asiaticoside effectively reduced the apoptotic factor (caspase-3), increasing the production of NO by activating the Akt/eNOS pathway. They confirmed that asiaticoside protected pulmonary hypertension by affecting endothelial cell function effect. And asiatic acid has anti-hypertensive and anti-inflammatory effects.
A clinical prospective, placebo-controlled, randomized, dose range trial found that after 4 weeks of treatment with Centella asiatica total triterpenes, the capillary filtration rate, ankle circumference and ankle edema of patients with venous hypertension were improved, and the dose range showed that 180 mg/day was most effective in symptoms improvement.
Atherosclerosis is a disease in which the inside of arteries narrows due to the buildup of plaque, leading to some serious problems such as heart attack, stroke, or even death. Maintaining arterial integrity and retaining endothelial barrier function and normal contraction of smooth muscle can limit the development of atherosclerotic disease. Asiaticoside has been found to reduce endothelial permeability; it can effectively protect the occurrence of atherosclerosis by lowering the levels of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin. Moreover, it can also reduce the levels of related inflammation factor (IL-18) and has anti-inflammation effects. A cell experiment found that asiatic acid reduced atherosclerosis by inhibiting the redistribution of occludin and zona occludens -1(ZO-1). Furthermore, it decreased F-actin rearrangement and myosin light chain dephosphorylation.
Clinical studies have shown that after 4 years of intervention in patients with Pycnogenol® 100 mg/day plus Centella asiatica (100 mg/day), the combined treatment group has reduced plaque progression, reduced oxidative stress, and mild transient brain deficiency as compared to the control group. The incidence of angina events in combined treatment group was less than 3%, while the control group it was 6.25%. Therefore, it can be established that Centella asiatica may have a role in preventing preclinical atherosclerosis. For improving the inflammation response, reducing oxidative stress and retaining the endothelial barrier function have beneficial effects on the occurrence and development of atherosclerosis.
Myocardial Ischemic Disease:
In myocardial ischemic disease, apoptosis is the main cause of cardiomyocyte death and asiatic acid could reduce the levels of apoptotic factors (Bax/Bcl-2, caspase-9, caspase-3) and improve cardiomyocyte apoptosis. It can also improve the fibrotic changes caused by myocardial dysfunction by affecting the TGF-b1-Smad2/3 signaling pathway. In addition,
Rosdah et al. pointed out that after administering Centella asiatica extract to rats at doses 200mg/kg and 400mg/kg for 21 days, the content of acetylcholine (ACh) in heart was modulated significantly, which might contribute to its cardioprotective effect. A summary of the related literature showed that asiatic acid and asiaticoside had beneficial effects on cardiovascular diseases. Basic experiments confirmed that these two triterpenoids effectively improved hypertension, atherosclerosis, and myocardial ischemia.
Arterial plaques are associated with atherosclerosis, coronary artery disease (CAD), and heart disease in general. When arterial plaques are structurally weak, they are more likely to rupture and cause embolism (artery obstruction/clotting). It has been proposed that a terpenoid extract in this plant may help to stabilize arterial plaque structure by increasing collagen composition. This might decrease the risk for plaque rupturing and subsequent embolisms.
A study on patients taking anti-aggregating medications showed a significant decrease in plaque echolucency in those on TTFCA.
Carotid and Femoral Plaques:
Carotid artery plaques that are echolucent on ultrasound have greater amounts of certain physiological components (e.g., lipids, blood elements) and limited amounts of collagen, making plaque inherently weaker and increasing the risk of embolization. This unstable plaque is associated with a higher clinical risk of stroke and asymptomatic cerebral lesions.
A study on asymptomatic patients (49 men, 38 women; mean age 56) with high-risk, echolucent carotid artery plaques were randomized to receive 60 mg triterpenoid fraction of Centella asiatica or placebo three times daily for one year; patients also took platelet anti-aggregating medication throughout the trial. After 12 months, sonographic evaluation in-dicated a significant decrease in plaque echolucency in the triterpenoid fraction of Centella asiatica group. Incidence of positive MRI images indicating cerebral ischemic lesions was seven percent in the triterpenoid fraction of Centella asiatica group and 17% in the control group.
In a second study testing a similar dose of Centella asiatica, patients with femoral plaques demonstrated a decrease in plaque echolucency after 12 months of therapy, compared to no change in the control group. Degree of stenosis and walking distance did not change in the two groups.
Platelet Aggregation Inhibition:
A 2016 study "In Vitro Antiplatelet Aggregation Activity of Centella asiatica (L.) Urban Ethanolic Extract" published in International Journal of Pharmaceutical and Clinical Research by Agatha Budi Susiana Lestari, Achmad Fudholi, Akhmad Kharis Nugroho, Erna Prawita Setyowati evaluated the anti-platelet aggregation activity of an ethanolic extract of Centella asiatica in male Sprague Dawley rats. In vitro study showed antiplatelet aggregation activity. n-Hexane purification of the CA herbs powder dose not affect antiplatelet aggregation activity significantly.
Gotu kola helps prevents blood clotting and as a herbal remedy may aid in alleviating the symptoms of thrombosis, which is defined as blood clotting in the blood vessels.
People who have low to medium rate venous disease in varicose veins were directed to add Pennywort in their daily routine for two days before the flight, on flight day, and a day after the flight. They found relatively less fluid retention and ankle swelling that skipped Pennywort. Pennywort can improve microcirculation in veins and arteries, protect arteries’ inner armor and improve the elasticity of veins. With this ability, Pennywort is often used to treat arteries’ hypertension in lower limbs. Gotu Kola is known to support healthy veins and vessels throughout the circulatory system. The most common problems due to degeneration or malfunction of blood circulation are varicose veins and haemorrhoids. When the extract of Gotu Kola leaves is consumed, triterpenes a molecule of Pennywort works on the veins, improving their tone and making them less susceptible to the degenerative processes that can lead to varicose veins and other problems.
Many lab studies and research have shown that Pennywort can be highly helpful in treating varicose veins. The reason is, Pennywort on the connective tissue of the vascular wall can impose positive metabolic effects. Whether you have varicose veins or experience ankle swelling after a flight, you'll be happy to learn that Pennywort is thought to reduce ankle swelling.
In a 2001 study, researchers tasked half the participants with taking Gotu Kola before, during, and after a flight, and found that those who did experienced reduced ankleand leg swelling compared to those who didn't take it.
Gotu Kola strengthens the vein and maintains the connective tissue functioning by stimulating the formation of chondroitin sulfate and hyaluronidase.
When blood vessels lose their elasticity, blood pools in the legs and fluid leaks out of the blood vessels. That causes the legs to swell (venous insufficiency). Several small studies suggest Gotu Kola may help reduce swelling and improve blood flow. Asiaticoside and madecassoside are two triterpenoid saponin compounds found in Gotu Kola. It is thought that these constituents may be responsible for the benefits to wound healing and venous insufficiency as they have been seen to have anti-inflammatory effects. Gotu Kola also seems to increase release of an inflammation mediator called IL-6 (interleukin-6).
Researchers think this might be responsible for the positive effects on venous insufficiency. BuUpregulated IL-6 release may also cause the antirheumatic effects proposed for this supplement. This herb may slow down activities of a group of enzymes that break down collagen, the primary structural protein found in skin and connective tissues. It also seems to simultaneously increase the rate that collagen is synthesized. A terpenoid extract from this plant improved remodeling in connective tissue in animal models. This is linked to increase activity of fibroblasts, increased epithelial turnover, decreased capillary permeability, and greater collagen synthesis.
In a double-blind study, 94 patients (86 men, 8 women; ages 20-80) with venous insufficiency of the lower extremities for an average of 14 years, were ran-domized to one of three treatment groups: a triterpenoid extract of Centella asiatica asiatica at a daily dose of 60 or 120 mg or placebo for three months. Individuals who took Centella asiatica at either dose demonstrated significant clinical improvements in limb heaviness, edema and global evaluation of efficacy. Venous distension, measured by plethysmography, was significantly better in the active group at 40 mmHg, 50 mmHg and 60 mmHg, compared to deteriorating placebo values.
In a study of 96 patients with venous insufficiency, use of a Triterpenoid Extract of Centella asiatica (TECA) demonstrated significant clinical improvements in limb heaviness, edema, and venous distention. In a study of 40 patients with severe venous hypertension, a trial of the herbal extract showed a decrease in skin flux and rate of ankle swelling, with improvement in edema, restless limbs and change in skin color.
In another study of people with varicose veins, ultrasound tests showed that people who took Gotu Kola had less leakage of fluid.
Chronic Venous Insufficiency (CVI):
Venous insufficiency refers to inadequate blood flow through veins. This condition often results from dysfunction in the veins or one-way vein valves in the legs. Blood pools in the legs unable to return to the heart for pumping and can cause symptoms like burning, aching, pain, stinging, and swelling. One possible cause of venous insufficiency is loss of elasticity in blood vessels.
There is some evidence that Gotu Kola can improve blood circulation in people with Chronic Venous Insufficiency. CVI is a condition that presents when the valves or walls in our leg veins are not healthy and causes difficulties in circulating blood to the heart. Several clinical studies have suggested that Gotu Kola can improve blood flow and reduce swelling in people with chronic venous insufficiency, relative to placebo controls.
According to the NMCD, evidence from eight different studies suggests, “Taking Gotu Kola or a specific extract of Gotu Kola (Centellase) orally for 4-8 weeks seems to improve measures of circulation and decrease symptoms such as edema in patients with venous insufficiency".
In one study, Centella asiatica extract was observed to reduce leakage of fluids through blood vessels with compromised elasticity.
A 2013 review of studies from Malaysia concluded that older people treated with Gotu Kola showed significant improvement in CVI symptoms, including leg heaviness, pain, and edema (swelling due to fluid and inflammation).
If you are interested in learning more about Centella asiatica it is recommended that you speak with your doctor to determine if this supplement is right for your needs.
Varicose veins is a condition where veins swell up in the legs and feet, thereby obstructing the smooth flow of blood across organs and tissues. Gotu Kola, being rich in iron, has the potential to remove plaques from blood vessels, and thus regulates blood pressure and heals varicose veins. Several studies have suggested that gotu kola may be used to treat varicose veins and venous insufficiency.
According to the Memorial Sloan Kettering Cancer Center, several studies claim that Gotu Kola can help treat varicose veins and venous insufficiency. However, many of these studies date back to the early 2000s or earlier, more up-to-date research is necessary.
For example, an older study from 2001, found that participants who received 60 milligrams of triterpenic fraction of Gotu Kola twice daily for 8 weeks experienced improvements in the health of their veins. The participants all had conditions with significant vein involvement, such as severe venous hypertension and ankle swelling.
Another study from the same year, and from some of the same researchers, produced similar results. The study found that Gotu Kola extracts helped with diabetic microangiopathy by improving the function of the veins. This health issue affects people with diabetes and involves having unusually small blood vessels in various areas of the body.
Venous Hypertensive Angiopathy:
The NMCD rates Gotu Kola as possibly effective for venous insufficiency. This means that preliminary research shows that it works, but more studies are needed to determine efficacy for all people. There have been some promising results seen in studies using Centalla asiatica for atherosclerosis (Arterial Plaque Buildup), cognitive function, deep vein thrombosis, keloid scars, general scarring, stretch marks, and wound healing. Despite the long history of use of this plant in traditional medicine, human research is quite limited. More clinical research is needed to determine the therapeutic efficacy of Gotu Kola for these and other conditions. Centella asiatica products are available as dietary supplements in the United States. The FDA has not approved Gotu Kola as a drug to prevent or treat any medical conditions.
40 patients (21 males, 19 females; mean age 48 years) with severe venous hypertension, ankle swelling, and lipodermatosclerosis, were randomized to receive triterpenoid fraction of Centella asiatica 60 mg twice daily or placebo for eight weeks; patients in the study did not wear compression stockings. After trial conclusion, patients taking the herbal extract experienced a significant decrease in skin flux and rate of ankle swelling compared to baseline values. In addition, patients in the active group reported rapid clinical improvement, reflected by a reduction in the analogue scale line score (e.g., symptoms of edema, pain, restless limbs, swelling, and change in skin condition/color) from 9.5 at baseline to 4.5 after eight weeks.
In another study using Laser doppler evaluation, subjects taking 60 mg triterpenoid fraction of Centella asiatica twice daily for six weeks demonstrated a 29% decrease in resting flux, 52% increase in venoar-teriolar response and 66-mL reduction in leg volume 164). Similarly, those utilizing the herbal extract demonstrated 7.2% increase in pO2 and 9.6% reduction in pCO2.
Regular use of Gotu Kola is a natural way to get rid of the inflammation of the tissues around the teeth, often causing shrinkage of the gums and loosening of the teeth. It helps to improve overall dental health. Research has proven that extracts of Gotu Kola and pomegranate improves clinical symptoms of chronic periodontitis.
Removes Stains on Teeth:
Powder of Asiatic Pennywort can be used as tooth powder that removes stains on teeth and strengthens the gums.
A 2003 preliminary study "Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts" published in Int Acad Periodontol. results indicate that the combined use of extracts of Centella asiatica and P granatum pericarp significantly reduced the clinical signs of chronic periodontitis.
Rheumatoid Arthritis (RA):
Animal and cell experiments confirmed that madecassoside exerted an anti-rheumatoid effect. Rheumatoid arthritis is a chronic inflammatory joint disease that usually affects women and elderly people; the main pathological change is persistent synovitis. If not controlled well, it can lead to joint deformities and other diseases and decrease patients’ quality of life.
Studies confirmed that TNF-α is a powerful proinflammatory cytokine overexpressed in the synovium of patients with rheumatoid arthritis and reducing TNF-α production can effectively improve the symptoms of rheumatoid arthritis. In addition, matrix metalloproteinase (MMP)-13 is a specific protein associated with rheumatoid arthritis and may be involved in the physiological remodeling of synovial tissue.
The pharmacological study on madecassoside demonstrated that it can effectively lessen the related inflammatory factors in arthritis model rats (TNF-α ↓, IL-1b ↓, IL-6 ↓, IFN-γ ↓, IL-17 ↓). Animal experiments have confirmed that oral madecassoside (30 mg/kg) can significantly reduce the symptoms of arthritis, and can inhibit the secretion of inflammatory cytokines. However, in vitro experiments have found that madecassoside and madecassic acid, the main metabolite of madecassoside, cannot influence the secretion of inflammatory cytokines. It was subsequently suggested that madecassoside may exhibits anti-arthritis potency through affecting the secretion of IL-10 from Foxp3+ cells in lamina propria of intestine, thus regulates the immune function of rats with collagen-induced arthritis. The results of madecassoside pharmacokinetics experiments are poor, but it has significant bioavailability, can effectively reverse adjuvant-induced arthritis, and inhibit the migration and invasion of fibroblast-like synovial cells, however, it has no effect on cell proliferation. Wei-GuangYU et al. pointed out that madecassoside may have anti-arthritis activity by inhibiting the NF-κB/MMP-13 pathway.
In summary, madecassoside as a triterpene component of Centella asiatica, may have anti-arthritis effect, and the underlying mechanism is reduction in the level of inflammatory factors.
Osteoporosis is a bone metabolism disease, manifesting itself in the form of bone loss and structure degradation. Main targets are the middle-aged and elderly people over the age of 50. The occurrence of osteoporosis can be linked to other endocrine morbidities, like diabetes, obesity, thyroid hormone disease.
One of the more traditional uses for Gotu Kola is to use the extract topically. Gotu Kola has the ability to help replenish the skin by promoting collagen synthesis which helps keep the skin supple, firm, and above all, strong. This is why traditionally Gotu Kola was employed extensively to help promote healthy wound healing. These effects may extend to oral supplementation too, helping to optimize skin health from within. The only way this can be achieved, however, is to protect the triterpenes from our stomach acid as it degrades the main triterpene compounds responsible for enhancing skin health. This is why topical Gotu Kola works well for optimizing skin health as it is not degraded by stomach acid. As we discussed earlier, our innovative enteric coated Gotu Kola tablets help to preserve these delicate triterpene compounds, which allows them to exert their positive effects on our skin.
Since ancient times, it is used to treat many skin-related disorders such as eczema, erysipelas, leprosy, psoriasis, and eczema. Not only this, there are many cosmetic companies, which are interested in using this herb because of its facial beauty benefits. Gotu kola along with treating cellulite is used for all skin problems from acne to wrinkles. Gotu Kola increases the collagen production in the skin so it prevents skin aging and maintains the youthfulness of the skin. Gotu Kola when taken internally treats acne and when Gotu Kola oil is applied externally, it treats acne scars too. Gotu Kola also firms up the skin and prevents skin wrinkles. Gotu kola extract also can be used as a massage oil to treat and prevent stretch marks. Gotu Kola oil is also used to treat minor burns and most of the skin infections. Since Gotu Kola has been proven without doubt that it is very effective for treating all the skin problems, Gotu Kola based creams are widely available now. Try either the Gotu Kola cream or oil for external application and Gotu Kola tea for internal consumption. The plant’s richness in antioxidants and its saponins can improve and reduce the appearance of scars, blemishes, and wrinkles. It also prevents the accumulation of scar tissue, thereby keeping your skin beautiful even after an injury. Gotu Kola is a sought-after herb by cosmetic and pharmaceutical companies. With the saponins, this herb has the ability to treat various skin conditions like acne, dermatitis, and psoriasis. Topically it can heal skin ulcers and reduce wrinkles, lighten blemishes, delay signs of ageing and improve the varna or quality of the skin.
Some studies also suggest that the use of Gotu Kola or its components may be useful in the treatment of scleroderma. Gotu Kola is a common ingredient of cosmetics applied to skin photoaging also in cellulite and striae.
"The anti-inflammatory properties increase hydration and help soothe and repair dry, red, irritated skin", explains Shari Marchbein, MD, a dermatologist in New York City. That's why it's recommended for treating various skin conditions, especially those with symptoms such as redness and roughness (think psoriasis and eczema). Chiara Butler, a chemist at Function of Beauty, the brand's new manufacturers skin-care line utilizes the ingredient in some of its products, says two skin-beneficial compounds in the plant's chemical makeup are madecassoside and asiaticoside, both known for their soothing properties. "Cica also boosts circulation and has been shown to increase collagen production, improving skin firmness and elasticity", points out Dr. Marchbein.
To get rid of the above-said skin problems, it is recommended that one should use externally the powder of Gotu Kola and vaseline both in the morning and evening. The application of its extract helps to reduce skin scars. Its cream helps to reduce scarring. It is helpful to minimize pregnancy marks if the mix of Gotu Kola and vitamin E starts applying for about 6 months.
Used in Cosmetics:
Pennywort is cold and full of nutritious that is useful in beauty care also. The herb juice is a natural moisturizer for the skin, slowing down aging, removing scars, and stretch marks. It is also suitable for acne. Saponins found in Gotu Kola are mainly adept at improving the appearance of the skin. Many cosmetic and pharmaceutical companies are concerned in it because of its ability to reduce the appearance of scars, wrinkles, and other blemishes. It prevents the accumulation of scar tissue, which helps to keep your skin beautiful, even after an injury or a surgery. This antioxidant activity to reduce signs of aging is one of the reasons gotu kola is becoming so popular in the west. Gotu Kola is known among cosmetic and pharmaceutical companies for its ability to keep the skin beautiful, reduce signs of aging, scars, and blemishes. This ability of the plant is related to its high content of antioxidants and saponins. This plant can also be used to cure Psoriasis, a hyperproliferative skin disorder.
Centella asiatica is loaded with a plethora of favorable properties. It is a rich source of amino acids, beta carotene, fatty acids, and many potent phytochemicals. Due to these properties, Centella asiatica is not only an acceptable ingredient for your overall wellness but can also be very beneficial to the health of your skin. Many cosmetic manufacturers incorporate Centella asiatica extracts in their skincare products, often labeled "cica creams".
A cosmetic ingredient review "Safety Assessment of Centella asiatica-derived Ingredients as Used in Cosmetics" was done in 2015 in 1620 L Street, NW, Suite 1200, Washington, DC 20036-4702. The © Cosmetic Ingredient Review (CIR) Expert Panel reviewed the safety of 9 Centella asiatica-derived ingredients, used primarily as skin conditioning agents in cosmetic products. Panel concluded that CA extract, callus culture, flower/leaf/stem extract, meristem cell culture, meristem cell culture extract, and root extract are safe in present practices of use and concentration in cosmetic products.
Protection From UV Rays:
A 2012 study "Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts" published in International Journal of Molecular Medicine by In-Sook An, Sungkwan An, Sang-Mo Kang, Tae-Boo Choe, Sung Nae Lee, Hyun Hee Jang, Seunghee Bae evaluated the photoprotective role of titrated extract of Centella asiatica (TECA) via microRNA expression profiling analysis. Low dose TECA did not exhibit toxicity and showed a protective effect against UVB irradiation. Results suggest TECA may serve as potential natural chemoprotective agent against UVB-mediated damage in NHDFs through changes in expression of specific mRNAs.
Another 2011 study "Triterpene Composition and Bioactivities of Centella asiatica" published in Molecules by Puziah Hashim, Hamidah Sidek, Mohd Helme M. Helan, Aidawati Sabery, Uma Devi Palanisamy and Mohd Ilham evaluated leaves of Centella asiatica for triterpene composition and bioactivity such as collagen enhancement, antioxidant, anti-cellulite and UV protection properties. Study yielded significant amounts of madeccassoside (3.10 ± 4.58 mg/mL) and asiaticoside (1.97 ± 2.65 mg/mL), but low in asiatic and madecassic acid. Highest collagen synthesis was found at 50 mg/ml of extracts. Antioxidant activity was 84% compared to vitamin C (88%) and grape seed extract 83%. Centella asiatica extracts exhibited similar UV protection to OMC at 10% concentration. Results suggest potential application in food and pharmaceutical industries.
Extracts of Centella asiatica can combat the signs of aging. It helps the skin to rejuvenate itself and fights against photo-induced aging. Its fluid retention properties trap moisture in the dermal layers and make the skin appear more plump and young. Higher moisture content in the skin cells reduces wrinkles and erases fine lines from the skin. Centella Asiatica contains a lot of flavonoids and an active compound called Madecassoside, which serves as antioxidants that help neutralize the free radical damage caused by the sun and pollution exposure. They also improve blood circulation and the synthesis of collagen and skin tissue for maintaining a youthful complexion. Collagen also plays a key role to enhance skin elasticity and reduce the signs of aging like wrinkles and fine lines. Due to this ability of CA to increase collagen (type I & III) production, research suggests that it can have anti-ageing capabilities and can be used in treating photoageing skin as well. It can help the skin retain a plump and youthful appearance.
You can work the plant extract into almost any step of your skin-care routine, it’s incorporated into cleansers, toners, serums, and creams. “I like creams and serums because they sit on the skin for a long time for maximum efficacy”, says Nikita Wilson, a cosmetic chemist in New York City. Butler agrees, adding that a cica cream can be used either morning or night, or both. (It’s worth noting that Centella asiatica products are often spiked with a green tint to counteract the redness that comes with an inflamed complexion). It is recommends applying a "cica balm" on top of your retinoid in the p.m. because while retinoids can aggravate skin, the cica will prevent irritation. Things like pollution, cigarette smoke, alcohol, and radiation expose our bodies to things called free radicals, which have been shown to speed up aging and cause illness. But antioxidants, which Gotu Kola contains in spades, are thought to help neutralize the risk. "Gotu Kola's antioxidant properties help us fight signs of aging", says Sanders, who adds that it may even be used to reduce the appearance of cellulite and stretch marks.
A study by Gohil et al. found that Gotu Kola acted on the connective tissues of the vascular wall. In conditions of hypertensive microangiopathy and venous insufficiency, the herb improves microcirculatory parameters by lowering capillary filtration, making Gotu Kola a candidate for reducing the appearance of skin aging.
Regular use of this herb helps in slowing down aging process. Its anti aging properties help to rejuvenate body tissues and boosts body immunity. Lactating mothers can reap the benefits of this herb, as it increases milk secretion and also purifies it. Apart from these benefits the herb Gotu Kola also acts as an antipyretic. It helps to reduce fever and normalize body temperature. This herb may cause headache, rashes and giddiness when used in excess.
Centella asiatica is rich in amino acids, beta carotene, fatty acids, and phytochemicals, which provide powerful nutrients for the skin. Amino acids is a great hydrating ingredient to soothe rough and irritated skin.
The main active constituents of Centella asiatica are saponins known as asiaticosides, which have soothing and healing properties. One of the main reasons that so many companies use Centella for stretch marks is that it acts as a soothing agent to damaged skin. These constituents have powerful healing properties, which means they can calm irritated, pained skin. Gotu Kola has shown to reduce skin irritation, it is ideal to restore your skin’s moisture barrier so it can protect itself from breaking down even more, especially for sensitive skin which is red, inflamed, irritated or itchy. It helps reduce the visible signs of skin sensitivity such as itching and burning significantly. This is one of the reasons why it’s used in products for people with sensitive and acneic skin. It speeds healing, improves overall acne severity and prevents future blemishes and scarring. More benefits of the Centella asiatica extract include: antioxidant-boosting effects, antibacterial properties, hydration and reduced transepidermal water loss, as well as photoprotection.
First of all, it’s excellent for sensitive skin, and you don’t run the risk of it causing irritation, as so many other skincare products do. Second of all, because of these asiaticosides, Centella helps relieve itchiness, which can be frustrating and intense, especially when the stretch marks are new.
Gotu Kola can be good for those which use medication or ingredients that can be drying to the skin, like acne-fighting products, to not only soothe inflamation, but hydrate the dry areas, too. Other than products labeled as Centella asiatica or "Cica", you may have also noticed skin care formulated with only madecassoside. Madecassoside is a very popular ingredient for acne-prone skin because it controls inflamation and stimulates production of type III collagen, which is the second most abundant collagen in human tissues (whereas asiaticoside stimulates type I collagen).
One study has also demonstrated significant benefits of madecassoside use in the inhibition of hyperpigmentation caused by UV irradiation.
So, to sum up the benefits Gotu Kola extract could have when applied to skin: combats and reduces inflammation, speeds wound healing and recovery, improves circulation, boosts collagen, hydrates, increased skin resilience, antioxidant-boosting effects, antibacterial properties, and pigment-fading and photoprotection.
Gotu kola is rich in antioxidants and contains saponins which improve the appearance of the skin. Many cosmetic and pharmaceutical companies are interested in it because of its ability to reduce the appearance of scars, wrinkles, and other blemishes. According to research, Gotu Kola is also effective in the treatment of wounds, burns, and hypertrophic scars. Gotu Kola has rich amounts of terpenoids, which can significantly increase collagen synthesis in your body. It, in turn, can reduce existing stretch marks and prevent new stretch marks from showing up. Research has suggested that applying Gotu Kola extract on the skin can prevent stretch marks from growing and lighten their scars. This ingredient is already added to many skincare products, like serums, balms, cleansers, toners, and creams. You can, therefore, just go on with your standard regimen. Just check the ingredients before purchasing your products. Centella asiatica can be applied to the skin in the day or night. Or both. Gotu Kola can be helpful for older streaks, as well. By encouraging new skin layers to emerge, your stretch marks will begin to appear less and less severe. However, we make a point of recommending early treatment (ideally when the marks are still colored), to get the best result.
Gotu Kola is loaded with anti-inflammatory properties as well as antioxidants. It contains two compounds called madecassoside and asiaticoside, known to soothe the skin. The former is an antioxidant that protects your skin from damage caused by free radicals. It's excellent at soothing dryness, redness, roughness, inflammation and hydrating the skin. This is why it can treat symptoms of conditions like eczema and psoriasis. It's also known to boost circulation for a youthful appearance and increase collagen production to firm the skin, reduce the visibility of wrinkles and lines, and improve elasticity. According to research, this ingredient can mitigate the effects of damage caused by exposure to the sun and revitalise the skin's protective barrier. And it has healing properties, prevents scarring, and strengthens the skin. Notice how the plant addresses most skin-related concerns and skin types, sensitive, dry, dull, and mature.
There are two specific multi-ingredient cream formulations (trofolastin and verum) containing Centella asiatica that have been observed to reduce the formation of stretch marks during pregnancy. Another topical cream product containing Centella asiatica triterpenes applied twice daily beginning at 10-14 weeks pregnant till the end of pregnancy has been observed to decrease the severity of both new and old stretch marks and the incidence of new stretch marks. These creams also contain other ingredients such as rosehip oil, vitamin E, elastin, and essential fatty acids. The effect of Gotu Kola alone is not known and more research is needed. Preliminary evidence suggests that using a skin cream called Alpha centella two times a day for 6 – 8 weeks might reduce scarring after removal of surgical sutures. This was noted in patients after receiving surgeries to remove excessive scar tissue formations called keloids. More research is needed to determine how gotu kola affects wound healing, scarring, stretch marks, and other dermatological conditions.
Something we find impressive about Centella asiatica is that it is supported by an abundance of clinical trials and studies. You see, we regularly hear about natural ingredients that may or may not be beneficial for stretch marks, but few are actually supported by evidence. Some studies suggested that the terpenoids found in Gotu Kola may help increase collagen production in the body, which may help prevent new stretch marks from forming and reduce the appearance of existing marks. However, it is advisable to do a patch test before using any topical medication.
A recent Indian study found that Centella asiatica was useful in reducing the appearance of stretch marks, especially when applied early during pregnancy. It also showed that Centella is completely safe for use during pregnancy and while breast-feeding, another plus.
In one open clinical trial, 227 patients were divided into two groups and treated with oral Centella asiatica alone or surgical scar revision plus Centella asiatica at doses of 60-150 mg daily for up to 18 months. In the Centella asiatica only group, 116 of 139 patients (82%) experienced relief of symptoms and disappearance of inflammation. In the 88 subjects in the combined surgery and Centella asiatica group, 72% demonstrated improvement. In addition to its oral use, Centella asiatica has been used as a topical cream in a com-prehensive scar management program. Observationally, it was found to improve scar maturity from an average of six months without treatment to 3 months with treatment.
Some studies "Medicinal uses and Toxic effects of Centella asiatica" from 2014 published in Daffodil International University by Jeasminsultana and "Diuretic Activity of Methanolic and Ethanolic Extracts of Centella asiatica Leaves in Rats" from 2011 by Chitrala Roopesh et al. suggest that the use of a special mixture of gotu kola, vitamin E, and a collagen compound in a cream (Trofolastin) in the last six months of pregnancy might reduce stretch marks associated with pregnancy. Another study suggests a mixture of Gotu Kola, vitamin E, essential fatty acids, hyaluronic acid, elastin, and menthol in an ointment forms (Verum®0 might help prevent the same.
In a 2013 review, Gotu Kola claimed to minimize signs of stretch marks. The chemical compound called terpenoids in Gotu Kola increase the production of collagen in the body. This action heals scar and stretch marks and also prevents skin from forming new stretch marks.
Use a topical cream that includes 1% Gotu Kola extract. Apply it to affected areas several times a day for better results.
The Centella asiatica extract and its triterpenoids had certain therapeutic and relieving effects on acne, baldness, vitiligo, atopic dermatitis, and wounds. Acne is one of the most common skin disorders. Studies have pointed out that the activation of vascular endothelial cells and the involvement of inflammation responses are essential for the early stages of the development of acne lesions. Vitiligo is an acquired depigmenting disorder of the skin, and one of the most common skin diseases. Some studies suggested that oxidative stress may be the initial cause of this disease. The main targets of ROS are mitochondria, causing structural and functional changes. Atopic dermatitis, also known as atopic eczema, is a chronic relapsing inflammatory skin condition. This disease occurs due to skin barrier dysfunction, alterations in cell-mediated immune responses, and Immunoglobulin E(IgE)-mediated hypersensitivity. Skin is the largest organ of the human body playing a vital role in maintaining the body’s physiological homeostasis. The appearance of wounds can lead to an imbalance in physiological homeostasis. The stages of wound healing comprise inflammation, proliferation, epithelialization, angiogenesis, remodeling, and scarring.
According to the summary report by 1998 committee for veterinary medicinal products, the transdermal absorption of the active ingredients in Centella asiatica in rats showed that madecassic acid can quickly penetrate the skin barrier, but the dose measured at the drug application point on the skin after 24 hour was only 0.06% concentrated as compared to the original dose. The results of asiatic acid were similar to madecassic acid. The high concentration of asiaticoside administered transdermally did not cause any systemic toxicity, but it could cause excessive keratinization of the skin at the application site. Some reports also suggested allergic dermatitis over using Centella asiatica externally, but none of them reports the exact dose. Centella asiatica and its triterpenoids are made into different formulations to explore the treatment options for skin diseases, and it has been established that they have a potential role in wound healing and skin inflammation.
For wound healing, the present study found that Centella asiatica and its triterpenoids had a direct wound-healing function. Centella asiatica extracted with methanol contains 0.12% asiatic acid, 0.54% madecassic acid, 0.25% asiaticoside and 1.02% madecassoside, and was made into a spray with hydroxypropyl-β-cyclodextrin, Eudragit E100, glycerin, PEG 400, etc., and the spray of triterpenes content are close to 100% compared with Centella asiatica extract, the wound was healed completely without any skin irritation. Compared with ordinary gauze, the electrospun gelatin membranes containing Centella asiatica can promote the wound repair process by affecting the proliferation of fibroblasts and collagen synthesis, and are antibacterial as well. The asiaticoside-rich hydrogel formulation exhibited 40% fast wound healing without any skin irritation as compared to untreated group. Thick epithelial layer and keratin formation can be found, while granulation tissue, fibroblasts and collagen were formed moderately. Cells studies have found that Centella asiatica standard extract (ECa 233) can affect the formation of filopodia and promote wound healing by activating the FAK, Akt and MAPK signaling pathways. In above studies, though the vehicles were different, but animal and cell experiments have found that Centella asiatica and its triterpenoids improved the degree of re-epithelialization, increased the collagen synthesis, reduced the inflammation around wounds and cause no obvious skin irritation.
For the treatment of atopic dermatitis, Centella asiatica significantly reduced the inflammation response (TNF-α ↓, IL-1β ↓, IL-8 ↓, IL-4 ↓, and IL-13 ↓), and also the local immune response (IgE ↓). Whether titrated extract of Centella asiatica or ethanol extract of Centella asiatica, both seems to inhibit hyperkeratosis, mast cell and inflammatory cell infiltration. Both of them can inhibit the expression of iNOS and COX-2 and NF -κB activity, it confirms that Centella asiatica extract may be a promising therapeutic for the treatment of atopic dermatitis. The effect of madecassoside in the treatment of dermatitis is reflected in reducing the pro-inflammatory cytokines (IL-1β, TLR2), moreover, it can promote the secretion of AQP3, LOR, IVL in HaCaT keratinocytes and the secretion of HA in human skin fibroblasts, thus can significantly enhance skin hydration.
Madecassoside, a specific component of Centella asiatica, had a certain improvement effect on vitiligo, and the possible mechanism of action was to reduce the oxidative stress response and weaken the damage to mitochondria by oxidative stress [matrix metalloproteinase (MMP) ↑ and [Ca2+]i ↓]. In addition, it was found that the LC3-II/LC3-I ratio of melanocytes treated with madecassoside increased significantly, suggesting that it enhances the autophagy activation of the cells, thereby protecting skin cells from physiological and pathological aging damage. Lastly, Centella asiatica also demonstrated a positive activation effect on dermal papilla, improved the viability of dermal papilla cells and increased the expression of characteristic genes related to hair growth in the cells, thus providing good application prospects for baldness.
Although Centella asiatica and its triterpenoids have low transdermal absorption rate, current animal experiments and cell experiments have found that they can effectively promote wound healing, reduce skin inflammatory diseases, and seem to have a certain effect on vitiligo and baldness. The mechanism of action of Centella asiatica and its ingredients in the treatment of skin diseases is mainly anti-inflammation, anti-oxidation, and weakening of the damage to mitochondria by oxidative stress, which was consistent with the pathogenesis of these diseases.
¼ of soaked rice ground with Gotu Kola leaves and can be added Onions and Rotis are made. This herbal roti cures skin diseases.
Your skin is the largest organ of your body which plays essential roles like generating vitamin D, preventing dehydration, and maintaining your body temperature. It’s also constantly exposed to the elements and to bacteria, which makes it prone to infection and inflammation. One common skin condition is psoriasis. Data shows that 125 million people. Gotu Kola can inhibit skin cell reproduction. Although not potent, it can be used as an herbal aid in providing relief from symptoms of psoriasis, which is a hyperproliferative skin disorder.
A 2011 study "Diuretic Activity of Methanolic and Ethanolic Extracts of Centella asiatica Leaves in Rats" published by Chitrala Roopesh et al. suggest use on gotu kola on the skin might reduce the symptoms of psoriasis.
It is the best remedy for skin diseases like eczema and psoriasis. Boil Centella leaves with cow ghee and make it cool and apply on the skin.
Oral and topical use have reported benefits on wound and scar management with relief of symptoms, disappearance of inflammation and hastening of scar maturity.
Wounds, Burns and Injuries:
As kids, we are always falling and covered in bruises and wounds. What our elders would do is take a bunch of Gotu Kola leaves, moisten the herb with saliva chew it for a while. With chewing it becomes dark green in colour. This is then taken out and applied on the wound with a bandage wrapped around it. The bandage is left for a day. Depending on the intensity of the wound, the dressing is changed. Gotu Kola has long been used traditionally in many civilizations to heal wounds, both internally and topically. Once famous for its use in treating leprosy in India, in Ayurveda, Gotu Kola is used today by herbalists to treat burns, minimize scarring, heal wounds, and promote tissue repair after injury or surgery. It appears to promote wound healing through its anti-inflammatory, antioxidant, and antibacterial qualities, in addition to stimulating keratinization (an integral process of nail and hair growth) and epidermal repair (the epidermis is the outermost layer of the skin). The main component asiaticoside helps in increasing type 1 collagen formation and angiogenesis thus heals wound rapidly. These compounds also inhibit inflammatory and improve capillary permeability. Its use is recommended in open sores and chronic wounds. A set of lab studies and medical records showed that the Gotu Kola extract could regenerate connective tissues to generate new skin and stimulate biological processes in cell division to heal wounds rapidly.
Pharmacological experiments have proven that the increased antioxidant activity of Gotu Kola indicates the wound healing properties of Gotu Kola extract. Gotu Kola provides the same healing property when consumed orally. When taken in its natural form or powdered form, the herb aid in stimulating blood flow to the cells and protects your immune system against infections, thus, speeding up the healing process in your body.
According to Gaia, the herb supports the structural integrity of skin and connective tissues. It is also purported to maintain normal skin keratinization, which is important for formation of nail and hair tissue.
A clinical study was done on wounds like clean cuts by sharp objects, blunt force trauma injuries, and infected rats. The wounds were dressed with Gotu Kola or Centella asiatica herb dressing and were seen to have improved wound healing qualities.
In in vitro and animal research, Centella asiatica has been shown to increase type 1 collagen synthesis, relative to type 2 collagen synthesis. Type 2 collagen is linked to hypertrophic scarring; meaning excessive scar tissue growth. By increasing type 1 collagen, scarring may be reduced. Both animal and preliminary human research has shown Gotu Kola to speed up wound healing. These effects are attributed to collagen preserving/increasing effects. Gotu Kola also seems to tighten the skin, helping to smooth out wrinkles and increase firmness. Asiaticoside constituents in Centella asiatica might decrease wound healing times by upregulating the production of collagen and of long, unbranched polysaccharides called glycosaminoglycans. This increased production of collagen is thought to have beneficial effects elsewhere in the body as well.
The Memorial Sloan Kettering Cancer Center also highlight the lack of trials in humans and call for further testing before the effectiveness of Gotu Kola as a wound treatment can be confirmed. Centella asiatica extract is able to penetrate the skin well enough to be utilized effectively and has been known to treat wounds and burns for centuries. This has been shown in both in vitro and in vivo studies which back its effectiveness in wound healing. The way it does that is by promoting fibroblasts proliferation and collagen synthesis, as well as inhibiting the inflammatory phase of scars. It has also been observed that the triterpenoid components stimulate glycosaminoglycan, especially hyaluronic acid production.
An animal trial reported that different formulation of Gotu Kola topically applied on the open wound thrice daily for 24 days treatment period showed increase skin tissue growth with collagen synthesis at the site of the wound with increase tensile strength.
One in vitro study isolated a major constituent in Gotu Kola, asiaticoside, and demonstrated the proliferation of fibroblasts, which are specialized cells responsible for producing and maintaining the structure of connective tissue. Fibroblasts are integral to wound healing.
"Studies on the biological properties of extracts from Centella asiatica (L.) Urban herb" published by Bogdan Kędzia, Teresa Bobkiewicz-Kozłowska, Mirosława Furmanowa, Przemysław Mikołajczak, Elżbieta Hołderna-Kędzia, Irena Okulicz-Kozaryn, Joanna Wójcik, Joanna Guzewska, Waldemar Buchwald, Alina Mścisz, Przemysław M. Mrozikiewicz evaluated about wound healing activities of different extracts of Centella asiatica in incision and burn wound models.
In Asia, people often call Centella asiatica "tiger grass", believing that injured tigers roll in the herb because of its healing properties. Several reports offer evidence for these allegedly magical effects. Gotu Kola has another benefit in this healing arena: Its adaptogen-like qualities help with the emotional and physiological stresses of physical trauma. Calendula flowers (Calendula officinalis) also promote tissue repair and support the lymphatic system in fighting infection, so I frequently pair them with Gotu Kola. Along with Gotu Kola’s wound healing properties, it’s also applied topically to mollify a variety of skin conditions, including insect bites, seborrheic dermatitis, cold sores, eczema, psoriasis, and dry, irritated skin. I like to infuse the dry herb into sesame or coconut oil, which can be rubbed into the scalp to calm the mind, deepen sleep, and promote hair growth.
The University of Maryland Medical Center states that Gotu Kola has been used traditionally to improve wound healing and enhance mental clarity, as well as for various skin conditions including leprosy, psoriasis, eczema, and acne.
According to the UMM, Numerous clinical trials have shown that Gotu Kola indeed has beneficial dermatologic effects by helping to support the connective tissue that line many of the external surfaces of the body including the scalp and skin.
The authors of an April 2018 study published in Minerva Chirurgica evaluated Centella asiatica as a treatment to decrease surgical scarring. Patients receiving oral doses of the herb healed better and experienced less scarring.
A report published in the March 2017 edition of The Journal Medicine showed that burn patients directly applying Centella asiatica had more complete healing. Such application also decreased the risk of infection.
A 2016 study "Evaluation of the topical spray containing Centella asiatica extract and its efficacy on excision wounds in rats" published in Acta Pharmaceutica by Somchai Sawatdee, Kanuengnit Choochuay, Wirot Chanthorn, Teerapol Srichana evaluated the wound healing effect of a topical spray formulation on Centella asiatica. The extract was complexed with hydroxypropyl-ß-cyclodextrin (HP-ß-CD) and formulated with Eudragit E100, glycerol, PEG 400, copovidone, ethanol, and purified water. Skin irritation study showed the formulation was non-irritating in the rat model. Results showed complete healing after 14 days in the in vivo excision wound model.
A 2015 study on rats found that wound dressing containing Gotu Kola was effective in healing multiple types of wounds, including clean cuts, irregular tears and infected tissue, and blunt force trauma caused tears. However, most of the studies supporting this health benefit of Gotu Kola were conducted on animals or used artificial wounds created in labs. This means there is no good scientific evidence to support its use in humans.
A 2013 study "Centella asiatica in cosmetology" published in Postep Derm Alergol by Wiesława Bylka, Paulina Znajdek-Awiżeń, Elżbieta Studzińska-Sroka, Małgorzata Brzezińska about mechanisms where Centella asiatica has been found effective in the treatment of small wounds, hypertrophic wounds, burns, psoriasis, and scleroderma. This review paper describes the mechanisms involved i.e., promotion of fibroblast proliferation, increase of collagen synthesis and intracellular fibronectin content, and improved of tensile strength of newly formed skin, along with inhibition of inflammatory phase of hypertrophic scars and keloids. Studies have suggested potential use in the treatment of photoaging skin, cellulite, and striae.
Another 2012 experimental animal study "Wound healing activities of different extracts of Centella asiatica in incision and burn wound models" published in BMC Complementary and Alternative Medicine by Juraiporn Somboonwong, Mattana Kankaisre, Boonyong Tantisira and Mayuree H Tantisira evaluated the wound healing activities of various extracts of Centella asiatica in incision and partial-thickness burn wound models in rats. Results showed all extracts facilitated wound healing process in both models. The asiatic acid in the ethyl acetate extract seemed the most active component for wound healing. An aqueous-ethanol extract showed bacteriostatic activity to all gram-negative and gram-positive bacteria isolated from wounds of different etiology. Applied topically as 1% cream the extract showed tendency to reduce carrageenan-induced edema.
According to a 2010 review of studies, some research supports the use of Gotu Kola to help wounds and burns heal. The authors reported that many studies had found that Gotu Kola sped up wound healing. However, most of these studies involved animals or artificial wounds created in labs. This means that the herb may not have the same effects in humans. The authors also noted that a lack of medical supervision and knowledge about how Gotu Kola might react with medications made the herb potentially dangerous to use.
In a 2006 study on albino rats "Effect of Centella asiatica L (Umbelliferae) on Normal and Dexamethasone-Suppressed Wound Healing in Wistar Albino Rats" published in The Intern Journal of Lower Extremity Wounds, Vol. 5, No. 3 by B. Somashekar Shetty, Msc, PhD, S. L. Udupa, Msc, PhD, A. L. Udupa, MD, PhD, S. N. Somayaji, Msc, PhD was showed the leaf extract of Centella asiatica significantly promoted wound healing and was able to overcome the wound-healing suppression of dexamethasone.
You can find Gotu Kola in many creams for wound healing. Ask your health care provider if one is right for you. Apply an ointment that contains 1% Gotu kola extract on wounds several times a day. In addition to its internal use in healing injuries, Gotu Kola is used topically, in the form of poultices, compresses, soaks, and infused oils (don’t use infused oils on fresh burns). A compress is the simplest preparation: prepare a concentrated tea, strain it, and soak a clean washcloth in the tea when it’s still warm. Apply the cloth to the affected area several times per day. The proportions of tea to water aren’t essential for this herb, simply make the tea about three times as strong as you would make a tea to drink.
TECA, the titrated extract of Centella asiatica is a reconstituted mixture of three triterpenes extracted from the plant. Used extensive in Europe as a wound healing drug, it has been shown to stimulate collagen synthesis and increase tissue tensile strength. It has been found successful in the treatment of burns, scars and wound healing defects.
Cellulite is one big problem that every women faces and almost 90 to 95% of the women have cellulite. Because it affects almost all the women, the market for selling anti cellulite medicines, creams and lotions are also big. Every year millions are spent on anti cellulite creams and treatments but very few have been proven to be effective. Out of the few, Gotu Kola stands out for it’s use in reducing cellulite as it has been proven through research that it is very effective for reducing cellulite.
A research was conducted on 35 people and all the participants were measured in the glutes and deltoids for their cellulite. Out of the 35 participants, 20 people were given 60 mg of Gotu Kola in dry form and the rest of the participants took placebo. The results after 90 days showed reduction in fat tissues in all the people who consumed Gotu Kola supplements and the reduction in cellulite was more prominent in the glutes. Even research on the external application of Gotu Kola based cream has proven that gotu kola reduced cellulite significantly.
You can either consume in the form of tablets or in powder form. Finally we have scientific proof that a herb does reduce cellulite.
A single study published in University of Maryland Medical Center found Gotu Kola decreased joint pain and skin hardening and improved finger movement.
Packed with nutrients that promote oxygen supply to the brain, Gotu Kola is very beneficial in decreasing levels of stress, anxiety and depression. It also has mild sedative properties and is hence useful for those suffering from insomnia and other sleep disorders. Gotu Kola increases levels of the feel-good neurotransmitters serotonin, dopamine, and norepinephrine, and reduces levels of the stress hormone cortisol. Additionally, Gotu Kola protects the brain from inflammation. Chronic inflammation of the brain is now thought to be an underlying cause of depression.
In human studies, Gotu Kola increased calmness, contentedness, and alertness and reduced symptoms of anxiety and depression. It has been shown to lower symptoms of anxiety and stress in those with generalized anxiety disorder. Gotu Kola significantly reduces the startle response caused by sudden noises within 30-60 minutes after ingestion. Since the acoustic startle response is a reliable way to tell if someone is anxious, this is another indicator that this herb may be useful for treating anxiety.
Stress is becoming a common factor in the present age with a hectic lifestyle, and daily pressure in different forms. Stress can lead to sleep deprivation, the result of which is anxiety. Gotu Kola has immense therapeutic potential. The herb has a positive effect on anxiety issues. It calms the adrenal glands, which in turn lowers the release of stress hormone and increases dopamine and serotonin levels.
One of the Gotu Kola benefits is in its powerful stress relieving abilities. It raises the levels of the “feel good” neurotransmitters dopamine and serotonin, and lowers levels of the stress hormone cortisol. It can eliminate anxiety, depression, mental fatigue, and insomnia. A wonderful Ayurvedic remedy for stress disorders.
Research findings have found that Gotu Kola extract may help regulate stress levels by positively influencing the calming areas of the brain. These calming brain regions respond to a relaxing neurotransmitter called GABA and Gotu Kola has a gentle yet prominently positive influence of GABA signaling. This has been found to regulate tension related to stress which helps keep us level headed during abnormal periods of stress.
Acute and Chronic Stress:
Gotu Kola can lower acute and chronic stress. It imposes calmness and alertness into our mind and body by 100%. There are many scientific research and lab studies that showed Gotu Kola could be used to treat anxiety symptoms as it can reduce the reactions of the acoustic startle reflex, which is considered the main sign that a person is in heavy mental stress.
In an animal study, rats induced with chronic stress and depression were given Gotu Kola showed a positive effect on their depression and stress behaviors in addition to heart rate, body temperature, and weight.
Gotu Kola is a natural anxiety reliever. Centella asiatica also has anxiolytic properties. The components madecassoside and asiaticoside possess anxiolytic activity. These compounds help in the treatment of both acute and chronic anxiety in the pathological state. It can have a positive effect on anxiety issues as it lowers the stress hormone, cortisol, and increases serotonin and dopamine levels. It effectively decreases the frequency and severity of anxiety attacks and episodes in a group of subjects who suffered from some form of General Anxiety Disorder (GAD). The anti-inflammatory properties of this herb can lower the signs of depression and despair. It is also known to enhance spirituality, thus, sometimes referred to as the "Herb of Enlightenment". Very little scientific evidence suggests that Gotu Kola may help reduce anxiety. Although the exact chemical pathways are still being researched, there is significant evidence that Gotu Kola can have a positive effect on anxiety issues for a broad range of patients. Research has revealed that it reduced the frequency and harshness of anxiety attacks and episodes in a group of subjects who suffered from some form of GAD. Based on a test on a group of people who suffer from a form of GAD, the use of Gotu Kola benefits the body by decreasing the occurrence and seriousness of anxiety episodes.
This herb has been studied for anxiety and appears to exhibit some anxiolytic effects. This means that it reduces experiences of anxiousness. Some evidence suggests that use of oral Gotu Kola supplements may decrease the Acoustic Startle Response (ASR), in healthy people. This startle response has been validated as a test of anxiety levels. Centella is said to induce calming, relaxing, slightly-sedative effects. More research is needed to determine whether this supplement is effective for alleviating anxiety in clinical settings. Several studies have confirmed the anti-anxiety effect of Gotu Kola.
In a study, participants who took Gotu Kola in place of their antidepressant medication for 60 days, self-reported decreased stress, anxiety and depression.
Another study showed that Gotu Kola had an anti-anxiety effect on mice that were sleep deprived for 72 hours. The study done with herbal medicines showed that Gotu Kola or Centella Asiatica has an acute anxiolytic effect. These same chemicals, triterpenoids, seem to reduce anxiety and increase mental function in mice. However, larger studies are needed to confirm these findings.
One human study found that people who took Gotu Kola were less likely to be startled by a new noise than those who took placebo. Since the "startle noise" response can be a way to tell if someone is anxious, researchers think that Gotu Kola might help reduce anxiety symptoms. But the dose used in this study was very high, so it is impossible to say how Gotu Kola might be used to treat anxiety.
In vitro studies have shown that Centella asiatica may bind to both GABA (Gamma Aminobutyric Acid) and CCK (Cholecystokinin) receptors. Stimulating GABA receptors may be responsible for the anti-anxiety effect. It has been hypothesized that activation of GABA receptors may also promote analgesic (pain-relieving), anticonvulsant, and sedative effects, however this hypothesis has not been tested in any research trials yet.
According to Winchester Hospital, an older study of 40 participants found that Gotu Kola helped improve the startle response. This is relevant because, as the hospital explains, easy startling is associated with anxiety. Confirming whether the herb can relieve anxiety will require larger studies of better design.
In 2016, an animal study was performed to witness the anti-anxiety ability of Gotu Kola in male mice that had undergone sleep deprivation for three days (72 hours). Sleep deprivation is one of the primary reasons for anxiety, neuroinflammation, and oxidative damage. The subjects were consumed Gotu Kola continuously for five days before they went to sleep deprivation. The result shows a significant reduction in abnormal anxiety behaviors. The mice showed improvement in oxidative damage and their locomotor activity.
In 2013, researchers reviewed various anti-anxiety medicines and herbs like Gotu Kola and concluded the herb has active anti-anxiety properties.
A 2000 study supports this ancient claim. After assessing baseline measurements of Acoustic Startle Response (ASR), mood self-rating scale, heart rate, and blood pressure, 40 healthy subjects (21 males, 19 females; ages 18-45 years) were randomized to receive 12 g non-standardized Centella asiatica dissolved in 300 mL grape juice or placebo. Evaluations were re-corded at 30, 60, 90, and 120 minutes after beginning therapy. Centella asiatica significantly decreased acoustic startle response amplitude compared to placebo at 30 and 60 minutes; heart rate, blood pressure, and mood did not change.
A 2000 double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subject on rats published in Journal of Clinical Psychopharmacology by Bradwejn J, Zhou Y, Koszycki D, Shlik J. has shown decrease in locomotor activity, enhanced maze performance and attenuated started response. This double-blind placebo- controlled study evaluated the anxiolytic activity of Gotu Kola in healthy subjects. Results showed Gotu Kola has anxiolytic activity in humans as shown by the Acoustic Startle Response (ASR). The study compared with placebo, Gotu Kola significantly attenuated acute acoustic response. Gotu Kola has anxiolytic activity in humans. It remains to be seen whether it has efficacy for use in anxiety syndromes.
In another 2000, The Journal of Clinical Psychopharmacology published research claiming that those who take Pennywort showed a significant reduction in their panic disorders. That means that Pennywort contains triterpenoids that help reduce anxiety and improve mental health.
Take 50 mg of Gotu Kola extract two times a day as a single dosage for two weeks (14 days). In the case of extreme anxiety, it is advised to take up to 2000 mg per day.
Depression is another mental disorder that can be treated with Gotu Kola. This herb can positively affect our brains, making them function properly; thus, it is a great antidepressant. If a person suffers depression then it has adverse effects in daily life. Gotu Kola can be used to treat depression. Because it has anti-depressant properties that can treat depression. Disorders such as anger, anger, frustration, irritability, restlessness, etc. can be used by using it. The triterpenes present in the plant Centella asiatica pose antidepressant effects. Studies done on the animal model suggested that the triterpene helps in creating a momentous diminution in corticosterone level and a notable increase in the amount of monoamine-related neurotransmitters.
A study was done on participants suffering from a similar disorder, in which they were asked to replace their antidepressant medication with Centella asiatica for 60 days. It was seen that there was a significant decrease in stress, anxiety and depression. It also calms down your heart rate and body temperature.
In 2016, a review of Gotu Kola’s antidepressant ability published in The Malaysian Journal of Medical Sciences was tested with 33 people who had anxiety disorders. The subjected people were directed to take Gotu Kola as a part of their treatment diet and plan for two months (60 days). All those ingested Gotu Kola reported decreased anxiety, stress, and depression. At the end, every individual reported reduced symptoms of stress, anxiety, and depression. While promising, if you're experiencing symptoms of mental strain, reach out to a mental healthcare provider before adding Gotu Kola to your wellness stack, especially if you're currently taking anxiety medication. Gotu kola may interfere with its effectiveness.
Another 2016 study "To evaluate and compare antidepressant activity of Centella asiatica in mice by using forced swimming test" published in IJBCP: International Journal of Basic & Clinical Pharmacology by Padmavathi Golla, Hemapriya Tirupathi evaluated the antidepressant-like effect of C. asiatica using forced swimming test (FST). Doses of 10 mg and 20 mg/kg significantly decreased immobility time, suggesting antidepressant activity. At 20 mg/kbw, the antidepressant activity was almost similar to standard drug imipramine (10 mg/kg).
Take 500 mg of Gotu kola as a single dose twice a day for 2 weeks.
The plant Gotu Kola possesses a central nervous system effect. It has tranquilizing, rejuvenating, and sedative properties along with memory-enhancing capacity due to compounds brahmoside and brahminoside.
Benefit for Nervous System:
By relieving stress, inducing sleep, and improving the mood, the Gotu Kola enhances the overall state of the nervous system. This prevents hair loss and it can also reduce the severity of epilepsy disorder if Gotu Kola is regularly taken. The herb boosts memory and grasping power. It is used as brain tonic . Its benefits in conditions like Alzheimer's disease ,anxiety and depression are also appreciated.
There are many health issues related to nervous disorder; such as Parkinson's disease that affects the central nervous system, Carpel tunnel syndrome, which causes numbness in the arms, paralysis, Bell's palsy, cerebral palsy, epilepsy, to name a few. These illnesses are related to the nervous system and can cause health complications. Gotu Kola has an antianxiety agent which helps in relieving stress, enhancing the mood and inducing sleep thereby calming the nervous system. The molecular mechanism of Gotu Kola on neuroprotection remains to be elucidated.
Gotu Kola has an anxiolytic activity that helps relieve stress, enhance mood, and induce sleep, thereby calming the nervous system. Calming effects of Gotu Kola that can reduce stress and stimulate healthy sleep can also calm the nervous system directly. For those who suffer from disorders like epilepsy or premature aging, it can have a powerful effect on the quality of life and the severity of the conditions if taken regularly.
Regeneration of Nervous Tissue:
Asiatic acid present in the leaves of Centella asiatica helps in the regeneration and enhancement of nervous tissue as per studies were done on human neuroblastoma cells. Therefore, enhances the learning memory.
A 2005 study "Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro" published in J Pharm Pharmacol. indicates components in Centella asiatica ethanolic extract may be beneficial for accelerating repair of damaged neurons. In a rat study, centella extract in the drinking water hastened recovery after nerve damage, with increased axonal regeneration and accelerated functional recovery.
If there was one plant that could reduce signs of anxiety and depression, you'd probably take it, right? Well, that plant might be Gotu Kola. "The herb is thought to have anti-anxiety and antidepressant qualities".
Centella asiatica has equally powerful effects on the mind. Furthermore, enhanced signaling through GABA allows for Gotu Kola to a promote a positive mood. Stress and other negative influences from our life may put us on edge and give us unpleasant feelings of nervousness. Gotu Kola extract may help smooth out this edge, allowing us to enjoy our life, and not worry about all the insignificant negative things that may be happening around us on a daily basis. It also may help increase our patience during periods of heightened irritability which can help us stay happy and focused on the important tasks at hand.
A 2017 systematic review and meta-analysis "Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes" published in Scientific Reports, Vol. 7 by Panupong Puttarak, Piyameth Dilokthornsakul, Surasak Saokaew, Teerapon Dhippayom et al. where Centella asiatica has been used as a brain tonic for mental disorders and enhancement of memory. This systematic review includes five randomized controlled trials conducted to determine the effects of Centella asiatica on cognitive function and its related properties. Meta-analysis indicated that there are no significant differences in all cognitive function domains of Centella asiatica when compared to placebo. However, it could improve mood by improving alertness and relieving anger. There are limitations on dose regimens, plant preparation, standardization and product variation. Well-designed trials are suggested. The review described the herb's alerting properties. In human trials, daily use of Centella asiatica increased feelings of alertness and calmness. It also had a positive effect on anger management. These calming effects appeared within a few minutes of taking the herb. The authors placed great emphasis on the safety of Centella asiatica. Multiple studies showed that the participants taking the herb reported no side effects. Yet, physicians caution about the remote possibility of liver damage.
Aids in Meditation:
Gotu Kola herb as a meditation aid. It balances the right and left hemispheres of the brain. This balance helps the nervous system function without any blockages and improves cognitive abilities. Since it enhances spirituality, they call it the "enlightenment herb".
It is said to develop the crown chakra, which is the key energy centre at the top of the head, and balance the right and left hemispheres of the brain, which the leaf is said to resemble. Moreover, it possesses antidepressant properties and naturally calms nerves, inhibits anxiety, promotes better sleep and helps treat depression.
There is a large overlap between the stress regulation and mood support effects of Gotu Kola as it relates to sleep. This is largely due to the fact that a lot of these factors rely on GABA signaling. GABA is one of the main neurotransmitters responsible for slowing down brain activity which allows for efficient sleep-onset. Since Gotu Kola can help positively enhance GABA signaling in the brain, Gotu Kola extract may help us wind down at night, thus allowing us to fall asleep faster. We cover the sleep benefits of Gotu Kola in more detail in our blog about sleep.
Getting adequate sleep is one of the best things you can do for your brain. Gotu Kola has been used as a natural sleep aid for thousands of years. Researchers have found that one bad night of sleep can impair your mental faculties as much as being drunk. Chronic insomnia is a common modern malady, but the usual solution, sleep medication, is a bad idea since it robs you of restorative sleep and can cause significant memory loss.
Due to the anxiolytic effect of Centella asiatica, it is also claimed to have a powerful impact in treating sleep disorders. Considering it was herbal, it has minimal side effects on the neural functioning of your body. Its ability to soothe your nerve helps in inducing sleep and can be an effective treatment of insomnia. Gotu Kola is a natural remedy that is safe to use and improves sleep. In Thai medicine, this herb is traditionally ingested for centuries as a tea with honey to produce a calming effect, thus improving sleep.
Good quality sleep is essential for brain health. Lack of sleep can result in memory loss, mental illness, affect concentration, and attention. So, sleep disorders like insomnia have to be taken seriously and treated immediately. Insomnia is generally caused by stress, anxiety, and depression. Some people take sleeping pills and chemical remedies, though it offers a quick result, it is not good for their health because regular sleeping pills can affect memory power.
Gotu Kola is also suggested as a herbal remedy to treat insomnia that sometimes accompanies anxiety, stress, and depression. Proponents of this herbal remedy consider it a safer alternative to prescription medications used to treat insomnia and other sleep disorders. But consult a doctor before trying this herb. Even a few research claims that Gotu Kola helps treat sleep disorders.
Gotu Kola acts as a sedative when given to animals in tests. Because of that, it is sometimes suggested to help people with insomnia. But no human studies have been done to see whether it works or whether it is safe.
Having the problems of insomnia and sleeplessness, it is effective in using this herb. Gotu Kola revives powers by re-establishing mental energy. This relieves your insomnia. For this, take 3 grams of Gotu Kola powder with milk before sleeping. 1 ½ teaspoon of Centella asiatica leaves boiled with water filter and drink it before bed. Traditionally, Gotu Kola tea is sweetened with a little honey as an Ayurvedic remedy for insomnia. Take 300 to 680 mg of Gotu Kola extract thrice a day for two weeks as a single dose.
Gotu Kola acts as a GABAa antagonist and inhibits the central cholinergic action. Gotu Kola also strengthening of the mucosal defensive factors. This herb increases body fire or agni. Hence its preparations are used in Indigestion, loss of appetite, conditions like Irritable Bowel Syndrome (IBS) and amoebiasis.
Gotu Kola possesses the noteworthy quality of being able to regulate digestion as it is loaded with proteins and vitamin C. It can also promote mucous secretions in the intestines which can help combat the increased acidity in severe gastric ulcers and effectively heal stomach aches.
Traditional medicine used Gotu Kola leaves to treat severe pain in the stomach, which we now link to gastric ulcers. This treatment is still considered practical, and the anti-inflammatory and antioxidant properties of the leaves can visibly improve the health of the gut and colon.
Centella asiatica and its triterpenoids also have therapeutic effects on digestive disorders, which is mainly reflected by improved liver fibrosis, colitis, and gastric mucosal damage; and even reduced Helicobacter pylori gastric colonization.
Centella asiatica extracts help in the inhibition of gastric ulcers. A stomach ulcer can be reduced and healed because of the asiaticoside that can be gained from Gotu Kola. This component benefits the body by acting as an anti-gastric ulcer drug. The antioxidant and anti-inflammatory properties that are found in the leaves of Gotu Kola benefits the by reinforcing the health of the gut and colon. It increases cell healing and reduces ulcers. The plants help in protecting and strengthening the mucosal barrier of the gastric tract thus protects from oxidative damage. The anti-ulcerogenic activity of fresh juice of Centella asiatica is mainly because it increases the GABA level of the brain. The healing efficiency and anti-inflammatory efficiency of the extract also help in protecting against ulcers.
A study has found that Gotu Kola can help with treatment of gastric ulcers. The tests have shown that Gotu Kola extract can help in healing ulcers and there is potential for it to be used as medicine.
Jadavpur University, India, has studied this effect and reported that the effectiveness of Gotu Kola in stomach ulcer treatment is higher than H2 blocker Pepcid treatment.
A 2010 study "Anti-ulcer activity of Centella asiatica leaf extract against ethanol-induced gastric mucosal injury in rats" published in Journal of Medicinal Plants Research Vol. 4 by M. A. Abdulla, F. H. AL-Bayaty, L. T. Younis and M. I. Abu Hassan evaluated the anti-ulcerogenic activity of an ethanol extract of Centella asiatica against ethanol induced gastric mucosal injury in rats. Pretreatment of leaf extract showed significant gastric mucosal protection, reduction or absence of edema and leukocytes infiltration of submucosal layer.
Fresh juice extract of Gotu Kola has shown protection against aspirin- and ethanol-induced gastric ulcers with increased gastric mucin secretion and mucosal cell glycoprotein production.
Detox the Body:
Recent studies are working on Gotu kola’s effect on toxicity in the kidney and liver.
An animal study in 2017 demonstrated that Gotu Kola is capable of reducing the toxin side effects of antibiotic isoniazid. The rats were ingested 100 mg Gotu Kola for a month, and after that, an antibiotic was given to them. After a study period, the rats showed fewer toxicity levels. The rats with liver and kidney toxicity experienced reduced or normalized toxin levels after intaking Gotu Kola.
Not only does it improve your immune system, but it also has detox effects. In an animal study done in 2014, Centella asiatica was found to have diminished the toxic effects of antibiotic isoniazid, used in the treatment of tuberculosis.
Take 30 to 60 mg Gotu Kola water extract thrice a day as a single dose for two weeks.
Chronic and Recurrent Liver Injuries:
Chronic and recurrent liver injuries are often accompanied by inflammatory reactions and often develop into liver fibrosis. Therefore, treating chronic and uncontrolled inflammation is a strategy to prevent liver injury and fibrosis. The pathological mechanism of gastric mucosal injury is complex, and nonsteroidal anti-inflammatory drugs are relatively common causes. Prostaglandin biosynthesis is one of the basic components that maintain the integrity of gastric mucosa, and cyclooxygenase is essential in the process of prostaglandin synthesis. The malondialdehyde level can reflect the ROS level. Therefore, an oxidative stress response is also crucial in the process of gastric mucosal injury. The present study found that the Centella asiatica extract effectively ameliorated the drug-induced liver toxicity, improved gastric mucosal injury, and reduced H. pylori infection. The mechanisms involved were as follows: the reduction of related inflammation factors (IL−1β ↓, IL−2 ↓, IL−6 ↓, IL−10 ↓, IL−12 ↓, and TNF−α ↓) and the increase in the level of antioxidant stress factors (SOD ↑, CAT ↑, and GPx ↑). Furthermore, evidence showed that Centella asiatica could also reduce malondialdehyde and COX-2 levels, thereby ameliorating gastric mucosal damage. The pharmacological effect of asiatic acid is mainly reflected in the improvement in liver fibrosis and acute pancreatitis. It also has a certain therapeutic effect on gastrointestinal tumors.
Three mechanisms are reported in the studies: asiatic acid can reduce the level of pro-apoptotic factors (B-cell lymphoma 2(Bcl-2) ↑, Bcl-2-associated X protein(Bax) ↓, caspase-3 ↓), and related inflammation factors (TGF-β1 ↓, TNF-α ↓, IL-6 ↓, IL-1β ↓), and increase the level of anti-oxidative stress factors (SOD ↑, GSH-Px ↑, CAT ↑, GST ↑, GSH ↑) 179). The study on madecassoside found that it could ameliorate drug-induced acute liver failure by reducing inflammation (TNF-α ↓, IL-1β ↓, IL-6 ↓, iNOS ↓, COX-2 ↓) and oxidative stress (SOD ↑, CAT ↑, GPx ↑, Nrf2 ↑, HO-1 ↑) 180). Oral administration of the four components of Centella asiatica could attenuate colitis in mice, but it’s mainly madecassoside acid, the active form of madecassoside, when topically administered in the colon, weakened colitis by regulating Th17/Treg balance via affecting the PPARγ/AMPK/ACC1 pathway.
Detoxification is very important, especially these days since we are exposed to tons of toxins in the environment, even through the food and water we consume to survive! herbs like Gotu Kola help cleanse the body and boost health. Gotu kola is a mild diuretic. It helps the body flush out excess salts, toxins, and fats though urination. This helps the kidneys get rid of unwanted matter very quickly and easily.
Gotu Kola has long been known as a mild diuretic and can, thus, stimulate the release of excess toxins, salts, water, and even fat from the body through urination. This release helps to ease tension on the kidneys and generally remove toxins quickly while keeping our energy up and our fluid balances even.
A 2011 study "Diuretic Activity of Methanolic and Ethanolic Extracts of Centella asiatica Leaves in Rats" published in IRJP by Chitrala Roopesh et al. investigated the diuretic effect of methanolic and ethanolic extracts of Centella asiatica in wistar rats. The extracts showed significant diuretic effect with increase in urine electrolyte concentration compared to standard drug furosemide (20 mg po). The ethanolic extract showed more potent diuretic effect than the methanolic extract.
Enhances Sex Drive:
There is even some traditional proof showing that Gotu Kola is used for an energetic boost in the bedroom. Increasing libido is often a side effect of other herbal remedies, and Gotu Kola is no exception. In addition to eliminating mental fatigue and increasing energy stores in the body, Gotu Kola can also bring some fire back to your relationship. These can help improve the sexual relationship between couples.
Take some dried Centella asiatica leaves, make it powder to mix with ¼ teaspoon of honey or mixed with cow milk taken two times a day. It will be increased.
Drink Gotu Kola powder mixed with fresh milk twice a day every morning and afternoon for three days once the menstruation is completed. The drink also treats dysmenorrheal. The cleansing properties of Gotu Kola benefit women with smooth skin, youthful look, proper blood circulation, and prevent diseases.
Pelvic Inflammatory Disease (PID):
Pelvic Inflammatory Disease (PID) is a microbial infection of the upper reproductive tract. Its major complications are infertility, chronic pelvic pain, rupture of a renal tubular ovarian abscess, and ectopic pregnancy. Western medicine uses antibiotics to effectively control the symptoms. However, no conclusive evidence indicated that antibiotic treatment for the pelvic inflammatory disease was safer or more effective than other methods. Asiatic acid can efficaciously treat pelvic inflammation. Asiatic acid has potential therapeutic effects on endometriosis and ovarian cancer.
Endometriosis is a common inflammatory disease often accompanied by pelvic pain and infertility. Generally, surgeries are conducted to treat endometriosis, but accumulating evidence suggest the use of plant-based drugs for the treatment, and these medicines usually alleviate the symptoms via their anti-inflammatory, anti-oxidant, anti-proliferation, and anti-apoptotic effects.
The main mechanism is reduction in the production of inflammatory body NLRP3 and inflammatory factors (IL−1 β, IL−6, TNF−α), inhibition of the NF−κB signaling pathway, which regulates the production of inflammatory factors, and thus alleviation of pelvic inflammation. Cell experiments confirmed that asiatic acid can effectively improve the symptoms of endometriosis. The main mechanism is inhibition of the NF-κB pathway to reduce the production of inflammatory factors (TNF-α ↓, IL-1β ↓, p-IκBα ↓, p- p65 ↓). The potential therapeutic value of asiatic acid for ovarian cancer is mainly reflected in that it can promote the apoptosis of ovarian cancer cells and inhibit the growth of ovarian cancer cells by affecting the cell cycle progression. In addition, studies found that asiatic acid improved the developmental ability of early embryos in pigs; the main underlying mechanism was amelioration of oxidative stress and downregulation of the expression of apoptosis-related genes. The potential therapeutic value of Centella asiatica for breast cancer mainly reflected in the promotion of apoptosis of breast cancer cells.
Therefore, this study concluded that the therapeutic effect of Centella asiatica on the gynecological diseases mainly reflected in the improvement in inflammation. The main research component was asiatic acid, which worked by affecting apoptosis, reducing the production of inflammatory factors and influencing the cell cycle progression. Therefore, asiatic acid may be a potential agent in the treatment of gynecological diseases, and further clinical trials are needed to verify its efficacy.
A 2007 study "Evaluating the effects of Centella asiatica on spermatogenesis in rats" published in Journal of Reproduction & Fertility by Mahnaz Heldari, Amir Hasan Jamshedi, Shahin akhondzadeh, Maerefat Ghaffari et al. evaluated the effects of C. asiatica extract on spermatogenesis and testicular tissue of rats. Results showed a calculated plant LD50 of 500 mg/kg. Results showed significant increase in body and testis weight in rats. Histological changes during spermatogonal evolution were degeneration of spermatozoa and interstitial congestion in some tubules. Sperm analysis showed decrease in number of spermatozoa (p<0.01), motile sperms (p<0.001) and epididymal sperm storage (p<0.001) with no changes in sperm morphology. Results suggest potential as temporary contraceptive agent in animals.
Gotu Kola comprises profuse volumes of the antioxidant asiatic acid and its derivatives. This provides neuroprotective effects to cells in the brain, advancing memory and learning. It also helps in slowing down the progression of Alzheimer’s and dementia, in older people affected by the disease. The antioxidants present in the herb stimulate the neural pathways and have a positive effect on the circulatory system which promotes cognitive functions. Gotu Kola extract has a positive impact on the circulatory system, thus oxygenating more of the brain and allowing cognition to improve. Also, due to the antioxidant effects of this herb, it can stimulate neural pathways by eliminating plaque and free radicals from the brain. It has been found that Centella asiatica extract, along with folic acid, has a very positive impact on brain activity and boosts cognitive functions. It improves your memory power. This has also made it a popular supplement for aging populations. The researchers suggest that Gotu Kola extract may have efficacy in preventing cognitive deficits and reducing oxidative stress. Studies in both animals and human participants have found the benefits of Gotu Kola extract in boosting cognitive function.
In a study on patients with vascular cognitive impairment due to stroke, Centella asiatica demonstrated improvement in their overall cognition.
A preliminary double-blind placebo-controlled human trial gave patients over 61 years old either a placebo or a treatment of 250, 500, or 750 mg of Gotu Kola daily and tested cognitive function and mood. It was found that cognitive function and mood were in improved in the treatment groups and most improved in the 750 mg group.
Not all studies have found positive results. Preliminary clinical research suggests that using a combination supplement containing Gotu Kola, Docosahexaenoic Acid (DHA), and Ginkgo biloba does not improve any marker of cognitive function, relative to placebo controls, in cognitively-intact elderly adults. More clinical research is needed to determine the therapeutic efficacy of Gotu Kola for cognitive function and disease. According to one review of studies, Gotu Kola may help support the functioning of the brain and nervous system, improve memory, and protect against aging. However, more recent studies do not support some of these claims.
A 2017 study found that Gotu Kola may improve alertness and reduce anger but did not substantiate the other findings.
A small 2016 study compared the effects of Gotu Kola extract (1,000 mg/750 mg per day) and folic acid (3 mg) in boosting cognitive function after a stroke. They found that few, if any, improvements were associated with using Gotu Kola, compared with folic acid. However, the authors noted that some participants experienced some improvement in long-term memory after taking the herbal extract. Gotu Kola was found to be comparatively more effective in improving memory domain. Due to its ability to enhance memory and nerve function, Gotu Kola is believed to be helpful in treating Alzheimer's disease. Folic acid and Gotu Kola both indeed do wonders in treating cognitive functions. But, the study shows that Gotu Kola was very effective than folic acid in boosting memory power.
A 2009 study "Comparison on Cognitive Effects of Centella Asiatica in Healthy Middle Age Female and Male Volunteers" published in European Journal of Scientific Research, No.4 by Roxana Dev Omar Dev, Suhaila Mohamed et al. findings suggest the potential for Centella asiatica to attenuate age-related decline in cognitive functions in healthy middle age and elderly adults. The mechanism/s underlying these effects require further investigation.
Take 750 to 1000 mg of Gotu Kola at a time in a day for two weeks (14 days). Another combination supplement contains 160mg Ginkgo biloba, 68mg Gotu Kola, and 180mg decosahexaenoic acid (DHA). This supplement was taken for 4 months without producing a significant benefit for cognitive function. Some users report that Centella asiatica has a time delay before its cognitive-enhancing effects may be noticed. According to anecdotal user reviews, the effects begin to be noticeable after about 2 weeks of usage.
Improvement of Learning Disability:
"Study of Ameliorating Effects of Ethanolic Extract of Centella asiatica on Learning and Memory Deficit in Animal Models" published in J Med Assoc Thai 2014 by Saowalak Doknark BSc, Salin Mingmalairak PhD, Anusara Vattanajun PhD, Boonyong Tantisira PhD, Mayuree H. Tantisira PhD showed an ameliorating effect of ethanolic extract of Centella asiatica on learning and memory impairment induced by transient bilateral common carotid arteries occlusion (T2VO). The positive effect could be, at least partly, attributable to its antioxidative effect on memory impairment caused by oxidative stress.
A 2002 placebo-controlled double-blind clinical trial "Evaluation of the Efficacy of Mentat in Children with Learning Disability" published in Neurosciences Today by Upadhyay, S.K., Bhatia, B.D., and Kala Suhas Kulkarni, M.D. about improvement of learning disability: Mentat is a polyherbal formulation containing Centella asiatica, together with B. monnieri, W. somnifera, N. jatamansi, A. calamus, T. cordifolia, E. officinalis, T. arjuna among others. Centella asiatica contains brahmic acid, isobrahmic acid, brahmoside and brahminoside. A double-blind placebo controlled trial evaluated the efficacy of Mentat in children with learning disability. Findings conclude Mentat improved attention and concentration in school children with learning disability.
Does Gotu Kola helps in boosting your grey matter? Gotu Kola is also popular as brain food. It enhances or improves your memory. When the aqueous extract of the whole plant is consumed, it enhances memory retention and learning and reduces the lipid peroxidation and growth of endogenous antioxidant enzymes in the brain. Gotu Kola extract has been used to treat Alzheimer's, a cognitive disorder and memory impairment disease.
Gotu Kola may regulate the activity of neurotransmitters known as Gamma-Aminobutyric Acid (GABA).2 Asiatic acid is the compound in Gotu Kola believed to trigger this effect. By influencing how GABA is absorbed by the brain, asiatic acid may be able to relieve anxiety without the sedative effect of traditional GABA agonist drugs like Ambien (zolpidem) and barbiturates. It may also play a role in treating depression, insomnia, and chronic fatigue.
Gotu Kola has long been used as an herbal tonic to treat mood disorders and enhance memory. Although research results are mixed, there is evidence of some direct and indirect benefits. In traditional medicine, Gotu Kola has been used as a natural tonic and antidote to enhance memory and treat mood swings or disorders. The herb is long used in Ayurvedic to treat mental and cognitive disorders. Gotu Kola also helps in stimulating your brain’s neural pathways by eliminating plaque and free radicals from the brain. In Indian Ayurvedic medicine, it has traditionally been used to improve memory.
Studies done on lab rats confirm that it has a memory-enhancing property, and therefore it can slow down the effects of Alzheimer’s disease, schizophrenia, and dementia.
In another animal study, Gotu Kola water extract was given to young and old mice to show the cognitive improving effects of Gotu Kola. Old and young mice showed noticeable improvement in memory and learning, but there was more effective in older mice.
Advanced scientific studies, have shown that Gotu Kola has a very special trick up its sleeve! It has been shown that Gotu Kola can help boost the growth and health of our brain. Gotu Kola does this by positively impacting a process called neuroplasticity which helps our brain adapt and form stronger connections. This process of adaptation and strengthening connections throughout the brain allows us to efficiently take in information, process it, and store it. The more neuroplasticity is taking place in the brain, the more efficient we may become at processing incoming information and integrating it into our daily lives.
What this all means is that Gotu Kola helps support overall cognitive health. This allows us to not only learn more but to also learn more efficiently. Long term supplementation of Gotu Kola extract may help us absorb school work faster and help us to pick up and solidify new skills in the work environment more readily. Based on many studies and research, Gotu Kola is possible to affect memory and cognition indirectly. Relief from anxiety and mental fatigue and more alertness undoubtedly improve the working memory of a person. Scientifically, a person with calmness and reduced anxiety experience better memory power, information processing, focusing, and concentration.
For example, the authors of a paper in the July 2018 edition of Brain and Behavior showed that Centella asiatica changed both the biology and the behavior of older mice, improving decision-making and memory. Most important, Centella asiatica rejuvenated the brain areas known to underlie these important cognitive functions. These data suggest that this traditional medicine may actually heal the brain.
A report published in the May 2018 edition of Evidence-based Complementary and Alternative Medicine reviews the positive role Centella asiatica can play in slowing the natural age-related decline in brain power. In fact, the traditional herb may eventually help treat dementia. Scientists continue to document these effects in animal studies.
A 2017 review of studies published in Scientific Reports found little evidence that Gotu Kola directly improves cognition or memory, although it appeared to promote alertness and relieve anxiety within an hour of consumption. It also included that consumption of Gotu Kola relieves anxiety and alertness with an hour.
An observation from Salem district, Tamil Nadu in 2013 "Merremia emarginata (Burm. F.) Hall. F.: A substituted market source for Centella asiatica (L.) Urban" published in Ancient Science of Life: Readers Viewpoint Letters by Saravanan Subramanian and M. Padmasorna Subramanian of M. emarginata for Centella asiatica (Takip kohol / Gotu kola): Medicinal plants collected from the wild are vulnerable to adulteration and substitution. Mandukaparni (Centella asiatica) is valued in Indian systems of medicine for improving memory and treatment of nervine disorders. This study reports on a plant material sold in the name of Vallarai that was not Centella asiatica and identified as Merremia emarginata (Kupit-kupit), a trailing plant that resembles Centella asiatica. The study stresses the importance of standardization of herbal drugs at raw drug levels by use of taxonomic and other validation methods.
A 2010 study "Enhancement of memory in rats with Centella asiatica" published in Biomedical Research Volume 21, Issue 4 by Silviya Rajakumari Jared evaluated the effect of C. asiatica on learning ability and memory in male Wistar rats measuring two important parameters using Operant conditioning technique, viz., latency period and total number of bar pressings. Results conclude that Centella asiatica facilitated retention of a learned task for a longer period suggesting good retention of memory but did not accelerate the learning process as expected.
Gotu Kola has been prescribed for improving memory for centuries. Centella leaves are shadow dried and powdered. The best way to consume Gotu Kola for memory is in the form of powder. You can either buy it from the markets or make your own. Since Gotu Kola is very very famous, most of the reputed companies manufacture Gotu Kola powder so getting good quality Gotu Kola powder is not a problem at all. But if you want to make it at home, you can easily make it within a day or two. Gotu Kola powder is made by steaming the fresh leaves and always cows milk is used to steam the leaves. To make the powder, collect fresh Gotu Kola leaves and clean them well. Now take a double boiler and fill the bottom part with milk. Spread a white cotton cloth on the idli steamer and spread the leaves on top of the cloth. Close with a lid and steam till it is cooked, once it is cooked, remove and spread it on a thin dry muslin cloth and shade dry till crisp. Once crisp, powder and store. The whole process should be done in a very low flame else the milk will boil over. To use, take around half tsp of Gotu Kola powder and mix it with a cup of sweetened milk. Make sure to dry the Gotu Kola leaves well else the powder will spoil faster.
Taking one teaspoon of this powder with honey twice in a day will boost the memory power. Dry the Centella asiatita leaves with Cumin seeds, Turmeric powder and grind it together. Taking 2 grams of this powder three times a day before food with hot milk will boost memory power.
Spatial Working Memory:
A 2018 study "Effect of Centella asiatica Ethanol Extract in Spatial Working Memory on Adult Male Rats" published in Advanced Science Letters by Suri, Auliyani Andam, Handayani Astri, Ferhad Adibah, Farida Siti, Redjeki Sri evaluated the effect of Centella asiatica ethanol extract on spatial working memory of normal adult male rats using Y-Maze before and after treatment. Treated groups showed better spatial working memory performance than control group.
Alzheimer’s is known as a disorder related to brain health. It is a dementing neurodegenerative disease of old age. Oral administration of Centella asiatica extracts helps in the prevention or slowing down of these diseases. The plant mainly involves reducing oxidative stress, prevents beta-amyloid plaque formation, dopamine neurotoxicity, and enzyme inhibition. Gotu Kola can enhance mood and cognition in both healthy seniors and those with Alzheimer’s disease. Alzheimer’s patients have significantly reduced levels of acetylcholine, a neurotransmitter strongly associated with memory and learning. Alzheimer’s drugs like Aricept work by blocking the breakdown of acetylcholine. Gotu Kola can effectively improve memory and enhance nerve functions. These characteristics of Gotu Kola make it a potential medicine for treating Alzheimer’s disease. The brain activity boosting the property of Centella aasiatica also has a potential effect on the treatment of this disease. Triterpenes, steroid precursors found in Gotu Kola, are beneficial for Alzheimer’s in two ways. Much like aricept, these compounds inhibit the breakdown of acetylcholine. They also prevent the formation of amyloid plaques that accumulate in the brains of people with Alzheimer’s disease.
Though there has not been enough study on the impact of Centella asiatica on human brains, a study done on mice with Alzheimer's disease showed it has a positive effect on their behavior. It might influence the plaque associated with Alzheimer's and can also protect the brain cells.
Preliminary clinical evidence suggests that asiaticoside derivatives from this plant may support brain function. Extracts from this plant have been found to exhibit neuroprotective properties. Asiatic acid, asiaticoside 6, and SM2 may help to protect nerves inside the brain from beta-amyloid toxicity, which is a common marker in Alzheimer’s disease. However, it is too early to determine whether this supplement can influence the risk of developing Alzheimer’s disease in humans.
Studies on stroke patients show it can improve cognitive function as it activates the release of Brain-Derived Neurotrophic Factor (BDNF), a protein that acts like fertilizer for your brain, encouraging new brain cell formation. Additionally, the triterpenes found in the herb prevent the formation of plaques that accumulate in the brains of Alzheimer’s patients.
Animal and preliminary clinical trials have shown that Gotu Kola may have positive effects on cognitive function, and possibly degenerative cognitive diseases such as Alzheimer’s disease.
One study showed cognitive-enhancing and antioxidant properties in healthy rats given Centella asiatica extract. In rats with streptozotocin-induced cognitive impairment (which has been likened to Alzheimer’s disease in humans) aqueous extracts of 100, 200, or 300 mg /kg of Centella asiatica or a placebo was given for 21 days. The treated rats showed increased antioxidant activity and cognitive behaviors in stress tests.
A small study in 2012 on mice with Alzheimer’s disease showed that Gotu Kola water extract possessed a significant effect on behavioral abnormalities. The plant extract was also tested in the lab and other animal studies to claim its effect on preventing toxic damages in brain cells. The herb prevents cells from creating plaque, which is related to Alzheimer’s disease.
Another 2012 study "Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action" published in International Journal of Alzheimer's Disease by Amala Soumyanath, Yong-Ping Zhong, Edward Henson, Teri Wadsworth, James Bishop, Bruce G. Gold, and Joseph F. Quinn evaluated the use of Centella asiatica herb to enhance memory and nerve function. A water extract of Centella asiatica in a murine model of Alzheimer's disease with high ß-amyloid burden. There was attenuation of ß-amyloid associated behavioral abnormalities in the mouse murine model of Alzheimer's disease. The combination of in vitro and animal studies support the Centella asiatica potential for clinical benefit in Alzheimer's disease.
However, there is insufficient research to determine how exactly Gotu Kola can be added to the treatment of Alzheimer’s disease. If you planned to add it to your treatment, consult with your doctor first. Take 30 to 60 drops of Gotu Kola water extract 3 times a day. Always check the dosage mentioned in the bottle as it may vary between different companies.
It is also a neurodegenerative disorder associated with the degeneration of dopaminergic neurons. Studies done on animal model shows a marked decrease of degeneration of neurons due to asiaticoside dose of Centella asiatica. It protects dopaminergic neurons by opposing MPTP (1- Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and improve locomotor dysfunction.
The extracts of Centella asiatica helps in the treatment of epileptic seizures. This is mainly because of the anticonvulsant and neuroprotective activity of the plant. Triterpenoid glycosidic compounds of Centella asiatica helps in increasing the cerebral level of GABA thus used in the treatment of epilepsy because of its anxiolytic and anticonvulsant properties.
A 2016 comparative study "Anticonvulsant action of aqueous extract of Centella asiatica and sodium valproate" published in Natl J Physiol Pharm Pharmacol. by Megaravalli R Manasa, Idoor D Sachin of Centella asiatica suppressed clonic seizures in mice. The anticonvulsant action was comparable to sodium valproate in PTZ-induced seizures.
Another 2010 study "The antiepileptic effect of Centella asiatica on the activities of Na + /K + , Mg 2+ and Ca 2+ -ATPases in rat brain during pentylenetetrazol-induced epilepsy" published in Indian Journ of Pharmacology Vol. 42, No. 2 by G Visweswari, K Siva Prasad, V Lokanatha, W Rajendra, the results showed the extracts of Centella asiatica, except the aqueous extract, possess anticonvulsant and neuroprotective activity and suggest a use in the management of epileptic seizures.
Gotu Kola has followed multiple mechanisms of actions on brain and neurological tissues to provide different therapeutic benefits. Cholecystokinin (CCKB) receptors bind with the peptide hormones cholecystokinin (CCK) or gastrin and regulate brain and GI tract functioning. Total triterpenes present in Gotu Kola improves the hypothalamic-pituitary-adrenal axis and increase the amount of monoamine neurotransmitters contents, which elevate mood.
Researchers had anticipated that Gotu Kola can bind with cholecystokinin receptors (CCKB) and play a potential role in anxiety modulation, anti-nociceptive action, regulates memory and hunger in animals and humans.
An animal research study also reported that treating animals with Gotu Kola can reduce corticosterone level and enhances 5-hydroxytryptamine, Norepinephrine, Dopamine, and their metabolites level. Gotu kola increases the GABA level in cerebral tissues.
Improves Brain Function:
Our brain cells are often affected by neurotoxins such as arsenic, aluminum, lead, and monosodium glutamate, which are the reason for mood disorders, mental fatigue, migraines, and brain fog. The anti-oxidant property of Gotu Kola reduces the effect of these neurotoxins. The hern neutralizes the toxins and protects our brain cells from damage. Gotu Kola effectively increases the development of new brain cells. It stimulates the Brain-derived Neurotrophic Factor (BDNF) to release, a protein that has essential play in neurogenesis. BDNF improves and strengthens existing brain cells and improves the growth of new brain cells. The herb boost plasticity in the brain enhances the branching of dendrite and improves brain cell communication. In this way, It takes a few weeks for Gotu Kola’s effects to kick in and it seems to work by encouraging dendrite branching, increasing brain plasticity, and facilitating communication between brain cells. Gotu Kola also increases Nerve Growth Factor (NGF), a protein which stimulates the growth of new nerve cells and safeguards existing ones. It is hypothesized that Centella asiatica may work by increasing how far neuronal dendrites reach in the brain. It does not seem to have any effect on the number of neurons present. Researchers think that administration of this herb extends dendrite reach by activating Mitogen-Activated Protein Kinases (MAPKs). MAPK activation increases release of BDNF (brain-derived neurotrophic factor), a growth factor that increases nerve cell growth. Several studies have attempted to examine the effects of this plant for cognitive function without producing definitive results. It is sometimes used in combination with other Ayurvedic herbs, which also contains Bacopa monneria, Gingko biloba, Cat’s claw, and Rosemary extract.
Vitamin E is known mostly as a heart-healthy vitamin, but it’s equally important for your brain. Vitamin E and C are combined to prevent cognitive decline due to aging. It also improves memory, cognitive functions, and effectively reduces the risk of Alzheimer’s and dementia diseases. Vitamin E supplements with Gotu Kola is an incredible anti-oxidant and supplement for brain health. This fat-soluble vitamin slows down age-related mental decline, particularly when paired with vitamin C. When taken together, “E + C” is linked to memory improvement and a reduced risk for Alzheimer’s and dementia. Gotu Kola shows similar synergistic effects with vitamin E, making “E + Gotu Kola” another powerful brain-enhancing combination.
It is used as a memory enhancer and also brain tonic. It helps to energies your brain cells and nerves. The leaves of this plant may be taken for the development of the brain. Powdered leaves along with cow’s milk are given for mental weakness and to improve memory. Because of its great significance as Ayurvedic medicine for the brain, sometimes, it is regarded as a brain food. It is also used to improve memory. It is beneficial for the mental ability of mentally retarded children. To a greater extent, it impacts the circulatory system thus more oxygen flow to the brain and promotes cognition. The antioxidant properties ensure the breaking of plaque in the brain.
Some studies have shown Gotu Kola extracts to have some potential as an antidepressant, antiepileptic, and can help revitalize the brain. However, most of these studies have only been conducted on rats so more studies on the benefits of Gotu Kola for humans need to be done to better understand it medical potential for the brain. Despite this, the current information that we have regarding Gotu Kola seems promising. The chemical compounds contained inside the plant have, indeed, shown that it can help with depression, epilepsy, as well as improve brain function. Gotu Kola is one of the most important rejuvenating herbs for nerve and brain cells and is capable of increasing intelligence, longevity and memory.
According to the study, The benefits of Gotu Kola can help reduce its symptoms. It revives the brain cells as well as improves the blood supply to the brain.
In one 2016 study, according to the Ayurvedic system of medicine, published in the Journal Evidence-Based Complementary and Alternative Medicine, researchers split participants into three groups: those who received 1,000 milligrams per day, those who received 750 mg of Gotu Kola, and those taking 3 milligrams of folic acid, which is a nutrient well-known for its brain-boosting benefits. After 6 weeks, all 3 groups showed a boost in cognitive function, suggesting that the herb may be as effective as folic acid at improving cognitive functioning. But only the group taking Gotu Kola showed improved memory, which suggests the herb is potent in supporting overall brain health.
Central Nervous System:
Gotu kola is recommended for reducing mental stress, improving memory power in the elderly, and boosting concentration. Asiaticoside in Gotu kola protects the neural cells from beta-amyloid toxicity and shows effective recovery in Alzheimer’s patients. The herb can relax the mind and aid several nervous disorders like stroke, senility, ADD, and epilepsy.
Ayurveda recommends the Gotu Kola herb as a Medhya rasayana (rejuvenative) for memory, concentration, alertness, and clarity. Its roots and leaves have the ability to help improve neurotransmitter functioning. This plant also offers neuroprotective benefits.
By taking Centella asiatica prepared as Gotu Kola leaves with Onion, Garlic, and Pepper for 48 days will cure the fatigue and helps you to come out of memory loss.
The plant Gotu Kola helps in enhancing the cognitive effects. These compounds help in repairing and restoration of damaged neurons and improve nerve impulse transmission. The main compound of Centella asiatica that repairs the brain cells are triterpene saponosides. Therefore the extracts of this plant help in the protection of neurological related disorders and enhance memory. Most plants have some antioxidant capacity, but gotu kola excels as a neuroprotective antioxidant. Gotu Kola protects the brain from damage incurred by the assaults of everyday life.
Studies show that Gotu Kola protects the brain from neurotoxins like lead, arsenic, aluminum, and glutamate. Glutamate is an important neurotransmitter, but, in excess, it actually kills brain cells. Glutamate is also found in some foods, especially those that contain added Monosodium Glutamate (MSG).
In vitro and vitro studies on Rattus norvegicus "Neurostimulant and neuroprotector effect of Centella asiatica (CeA)" published in Poster presentation on International Symposium of Austronesian Humanities and Custom Medicine - HerbalNet, A Digital Repository in Herbal Medicine by Khotimah Husnul, Riawan Wibi, Kalsum, Umi, evaluated the mechanism of Centella asiatica as neurostimulant and neuroprotector. Findings showed Centella asiatica improved memory function by increasing the arboration and elongation of dendrite branches due to increasing level of BDNF hippocampus. In vitro study showed neuroprotective effects in reducing apoptosis of neuronal cells through decreased expression of NFkB (nuclear factor kappa beta) and levels of tumor necrosis factor α.
A 2017 review "Centella asiatica: phytochemistry and mechanisms of neuroprotection and cognitive enhancement" published in Phytochemistry Reviews by Nora E. Gray, Armando Alcazar Magana, Parnian Lak, Kirsten M. Wright, Joseph Quinn, Jan F. Stevens, Claudia S. Maie, Amala Soumyana describes the phytochemistry and neurological effects of Centella asiatica. Many studies in rodent models and some human studies support Centella asiatica as a cognitive enhancer, anxiolytic, and anticonvulsant. Neuroprotective effects in invitro models include antioxidant improvement, inhibition of pro-inflammatory enzyme. Neurotropic effects include increased dendritic arborization and synaptogenesis. Many of these effects are attributed to triterpene compounds asiatic acid, asiaticoside, and madecassoside.
A 2016 morphological study in mice "Effect of Centella asiatica leaves extract on hippocampal CA3 neurons" published in International Journal of Anatomy and Research, Vol. 4 by Hemamalini, Rao M.S, showed a neuroprotective role for Centella asiatica leaves extract on hippocampal CA3 neurons against stress induced neurodegeneration in albino mice.
Another 2015 study "Protective Effect of Centella asiatica against Aluminium-Induced Neurotoxicity in Cerebral Cortex, Striatum, Hypothalamus and Hippocampus of Rat Brain-Histopathological, and Biochemical Approach" published in J Mol Biomark Diagn by Amjad S, Umesalma S, explored the neuroprotective effect of Centella asiatica on chronic aluminum chloride exposure induced neurotoxicity in various brain regions of Wistar albino rats. Results demonstrated neuroprotective potential against AlCl-3 induced oxidative damage and cognitive dysfunction.
A 2013 study "Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells" published in BMC Complementary and Alternative Medicine by Oraphan Wanakhachornkrai, Varisa Pongrakhananon, Preedakorn Chunhacha, Aree Wanasuntronwong, Anusara Vattanajun, Boonyong Tantisira, Pithi Chanvorachote and Mayuree H Tantisira, showed neurite outgrowth promoting activity of Eca 233. Besides the in vivo neuroprotective effect of ECa 233, study supports further development of ECa 233 for clinical use in neuronal injury or neurodegenerative diseases.
"Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria" published in International Journal of Phytotherapy and Phytopharmacology, 2008, Vol. 15, Issue 11 by Shinomol, George K. evaluated the propensity of dietary intake of Centella asiatica leaf powder to modulate oxidative markers in mouse brain regions and the efficacy to abrogate 3-NPA induced oxidative stress in mitochondria. Results showed Centella asiatica has the propensity to modulate both endogenous and neurotoxicant induced oxidative impairments in the brain and may have potential as neuroprotective adjuvant to abrogate oxidative stress in vivo.
The plant’s anti-inflammatory properties can help reduce pain and swelling and pain due to inflammation, heal wounds, fight infection, and speed up the process of healing. This occurs because of saponins and other organic compounds that can be found in Gotu Kola.
"In vitro Anti-Inflammatory activity of methanolic extract of Centella siatica by HRBC membrane stabilisation" published in Rasayan J. Chem, Vol 4, No 2, 2011 by Seema Chaitanya Chippada, Sharan Suresh Volluri, Srinivasa Rao Bammidi and Meena Vangalapati evaluated the in vitro anti-inflammatory activity of C. asiatica by HRBC membrane stabilization by hypotonicity induced membrane lysis. Maximum membrane stabilization of CA extracts was found to be 94.97% at a dose of 2000 µg/ml.
The antioxidants in Gotu Kola, flavonoids and carotenoids, remove toxins from the body, while its high calcium content fortifies bones. This Ayurvedic herb also supplies valuable anti-inflammatory effects to swollen, painful joints, hence efficiently reducing discomfort in ailments such as arthritis. Because of the presence of anti-inflammatory properties of Gotu Kola, it helps in relieving from joint pain. Research had shown that when Gotu Kola was administered orally it suppressed joint inflammation and can help improve collagen production in the body. It can act as an effective remedy for joint pain. The herb is also shown to reduce cartilage erosion and bone erosion.
In 2015, research was done on collagen-induced arthritis in rats. When administered with Centella asiatica orally, it was found that it can effectively reduce joint inflammation, bone erosion, and cartilage erosion.
Gotu Kola inhibits Nitric Oxide (NO) synthesis to reduce inflammation. Madecassoside, an active phytochemical present in Gotu Kola and effective to suppress action type II collagen-induced arthritis to reduce pain and inflammation associated with arthritis. Gotu Kola is a powerful anti-inflammatory and helps provide relief for those suffering from joint pain related to problems like arthritis. It’s supposed to improve joint function and relieve common arthritis symptoms.
An animal study in 2014 proved that Gotu Kola contains outstanding anti-inflammatory properties and is capable of rheumatoid arthritis. Consuming Gotu Kola decreases inflammation in joints, erosion in bone, and cartilage. The study also revealed that Gotu Kola improves the overall well-being in rats induced with collagen arthritis.
According to research published in 2009. After taking an active constituent of Gotu Kola for 21 days, participants experienced reduced joint damage and lower levels of pro-inflammatory cyclooxygenase-2, or COX-2 enzymes, as well as reduced levels of inflammation, leaving researcher to conclude the plant may serve as an effective natural treatment for some forms of arthritis.
In 2003, Sydney, a documentary was broadcasted that showed many Australian arthritis patients were cured by having two pennywort leaves a day. Mr. Russ Maslen, an arthritis and paradoxical pennywort author, helped his wife Beryl to get out of arthritis in her hand joints completely. In his book, he shared that he got to know the benefits of Gotu Kola for arthritis in 1989 by a farmer in Brunswick Valley when he was involved in constructing and administrating the natural reserve park.
Take 300 to 680 mg Gotu Kola extract thrice a day as a single dose for 2 weeks.
A single study of 13 women with scleroderma found that Gotu Kola decreased joint pain and skin hardening, and improved finger movement.
Type 2 diabetes mellitus is a form of diabetes characterized by high blood glucose, insulin resistance, and a weaker insulin-stimulated response in the presence of high blood glucose level. Oxidative stress is mainly caused by lipid peroxidation and has been considered as the main indicator of the pathogenesis and development of type 2 diabetes. Oxidative stress causes microvascular and macrovascular complications. In addition, the inflammation response may cause the occurrence of type 2 diabetes by inducing insulin resistance. The inflammation response is exacerbated in the presence of hyperglycemia and can, in turn, worsen hyperglycemia. Hence, targeting the inflammation pathway may be a potential strategy to prevent and control diabetes.
Shadow dry the Centella leaves and Lippia Nodiflora leaves separately and powders it. Diabetic patients can take 2 gms of equally mixed above two powders will reduce the sugar level.
A 2010 study "Evaluation of the Anti-diabetic Effect of Ethanolic and Methanolic Extracts of Centella asiatica Leaves Extract on Alloxan Induced Diabetic Rats" published in Advances in Biological Research 4 by P.K. Chauhan, I.P. Pandey and Vinod Kumar Dhatwalia evaluated ethanol and methanol extracts of leaves for anti-diabetic activity in normal and alloxan induced diabetic rats. Both extracts exhibited significant anti-diabetic activity compared to glibenclamide, with amelioration of alloxan induced biochemical damages with long-term treatment.
Gotu Kola is well known by the Khasis' people in helping to control blood sugar levels. The herb is steeped overnight in hot water, and the water is extracted and consumed the following day. Gotu Kola is a strong candidate for alleviating diabetic symptoms, and perhaps controlling the increase of diabetes mellitus, because of its various compounds and functions. Its extracts help in reducing the blood glucose level. Ayurvedic healers have traditionally used Centella asiatica to lower blood sugar. Research done in animals supports such use.
Studies done on the animal body shows that the extract of this juice lowers the blood glucose absorption by increasing the fibrosis of islets in diabetes which also plays a vital role in the prevention of islet dysfunction.
A 2016 experiment presented in The Journal of Ethnopharmacology tested Centella asiatica in an animal model of diabetes. Results indicated that the traditional herb reversed common symptoms of diabetes like high sugar levels. Even more important, Centella asiatica directly increased insulin production. The latter result suggests that Centella asiatica could directly heal the pancreas.
Diabetes is characterized by increased skin blood flow and decreased venous return, resulting in blood pooling from decreased venous return and increased skin blood flow.
A trial of TTFCA showed a significant reduction in skin blood flow compared to baseline values.
48 patients with diabetic microangiopathy were randomized to one of three treatment groups for six months: 60 mg triterpenoid fraction of Centella asiatica twice daily, placebo, or no treatment. Using laser doppler flowmetry measurements, the researchers concluded those taking triterpenoid fraction of Centella asiatica had significant reductions in skin blood flow at rest after three and six months compared to baseline values. In addition, VAR scores (decrease of skin blood flow on standing) increased significantly from 6.4 percent to 23.9% at three months and 25.9% at 6 months. During the investigation period, pO2 increased while pCO2 values decreased significantly in the Centella asiatica group. Fasting blood sugar and hemoglobin A1C values did not change.
In 2015, the World Health Organization (WHO) defined the body mass index more than 30 kg/m² as obesity and 25–30 kg/m² as overweight. Obesity is a risk factor for many diseases, including cardiovascular disease, musculoskeletal muscle disease, and even cancer. Furthermore, obesity causes chronic inflammation of the body and inflammation involving multiple organs (e.g., liver, heart, skeletal muscle, and brain).
Gotu Kola has anti-proliferative nature, which is beneficial in curing various types of cancer. There is growing interest in Gotu Kola as a possible anticancer/chemopreventive agent.
Centella leaves with castor oil boiled for some time and applies it to the tumors to reduce the severity. Some studies using dried powder extracts have shown antitumor and cytotoxic effects against tumor cells in vitro.
In preliminary in vitro and animal cancer studies, Centella asiatica extracts seem to target tumor cells selectively; meaning no damage is sustained by healthy, non-tumorous cells. Chemotherapy, a common cancer treatment in humans, often damages healthy cells as well as tumor cells. More research is being conducted to determine gotu kola’s anticancer potential in human cancers and its ability to potentially preserve healthy cells.
Colon Cancer and Liver Cancer:
Colon cancer and primary liver cancer are common types of cancers in the digestive system. The expression of E-cadherin and vimentin is considered of high reference value in the prognosis of colon cancer. The mitochondrial morphology and the cytosolic calcium level [Ca2+] are indicators of the pathological development of hepatocellular carcinoma. Asiatic acid can also affect the expression of epithelial-mesenchymal transition marker proteins in colon cancer cells (E cadherin↑, vimentin ↓, N-cadherin↓), achieved this anti-cancer potential by regulating PI3K/Akt/mTOR/p70S6K signaling pathway. In addition, asiatic acid can induce the dissipation of mitochondrial membrane potential (MMP), ATP depletion, release of cytochrome c from mitochondria into the cytosol of HepG2 cells, which may induce the death of liver cancer cells by directly affecting mitochondrial function, it may be a potential therapeutic drug for liver cancer and colon cancer.
Based on the aforementioned evidence, it was concluded that Centella asiatica maybe can improve liver, colon and stomach related digestive disorders by reducing inflammation, ameliorating oxidative stress, and improving mitochondrial function.
"Anti-carcinogenic activity of Centella asiatica and Elytropappus rhinocerotis on a human colon cancer cell line" published in Theses and dissertations (Applied Sciences) - DUT Durban Library by Dwarka, Depika, an Anti-Carcinogenic on Human Colon Cancer Cell Line Study investigated the anticancer potential of Centella asiatica and Elytropappus rhinocerotis. Results showed the plants induces apoptosis in CaCO-2 cells, an important step in elucidating the underlying molecular mechanism for anti-tumor activity.
Ovarian Cancer and Breast Cancer:
Ovarian cancer and breast cancer are the top two cancers in women. Surgery, radiotherapy, chemotherapy, and other treatments are often associated with various complications. Therefore, exploring new therapeutic agents is particularly important. The potential therapeutic value of asiatic acid for ovarian cancer is mainly reflected in that it can promote the apoptosis of ovarian cancer cells and inhibit the growth of ovarian cancer cells by affecting the cell cycle progression.
In test tube studies, asiatic acid in Gotu Kola showed its ability to induce natural cell death (apoptosis) in specific cancer types like breast cancer. In addition, studies found that asiatic acid improved the developmental ability of early embryos in pigs; the main underlying mechanism was amelioration of oxidative stress and downregulation of the expression of apoptosis-related genes. The potential therapeutic value of Centella asiatica for breast cancer mainly reflected in the promotion of apoptosis of breast cancer cells.
Gotu Kola significantly reduces radiation-induced behavioral changes.
The accumulated bronchial secretions or Kapha gets easily expectorated when this herb is used in respiratory conditions like bronchitis and asthma.It is very useful in inflammation of vocal chords. The effects of Centella asiatica on respiratory diseases is mainly reflected in its ability to improve pulmonary fibrosis, ameliorate chronic obstructive pulmonary disease, and decrease lung injury and certain anti-lung cancer effects.
A review found that pretreatment with asiatic acid can inhibit bleomycin-induced lung injury and fibrosis in mice. It can down-regulate the expression of pro-inflammatory factors, inhibit inflammatory cells infiltration and expression of transforming growth factor-β1. In a mouse model, lung inflammation was induced by exposure to cigarette smoke, oral administration of asiatic acid reduced the excessive production of mucus in lung tissues, inhibited the release of pro-inflammatory factors, and induce the expression of HO-1, which may become a potential drug for the treatment of COPD by regulating key progressions (Lee et al., 2016; Dong et al., 2017). The common possible mechanism was that asiatic acid could reduce the level of related inflammation factors (IL-6 ↓, TNF-a ↓). In addition, asiatic acid can inhibit collagen deposition in lung fibrosis diseases. Cell and animal experiments found that asiatic acid could reduce tumor volume, tumor migration, and differentiation. Furthermore, it also has the ability to promote tumor cell apoptosis (caspase-9 ↑, caspase-3 ↑). Therefore, asiatic acid may be a potential therapeutic drug for lung cancer. As for asiaticoside, the review found that it can reduce the inflammatory infiltration caused by lipopolysaccharide in a dose-dependent manner, and inhibit the inflammatory response in lung tissue by inhibiting the NF-κB signaling pathway (TNF-α ↓, IL-6 ↓, p-IκB ↓, p-p65 ↓), which can be an effective preventive agent for acute lung injury.
A 2013 study of an aqueous extract of Centella asiatica "Anti-Proliferative Activities of Centella Asiatica Extracts on Human Respiratory Epithelial Cells in vitro" published in Int. J. Morphol. by P. M. Mutua; M. M. Gicheru; A. N. Makanya and S. G. Kiama demonstrated a dose-dependent inhibitory effect towards the proliferation activities of human respiratory epithelial cells. Results suggest the possibility of using Centella asiatica extract as an anti-polyps therapy.
Therefore, the present studies showed that the effective components of Centella asiatica on respiratory diseases were asiatic acid and asiaticoside, and the major mechanism was anti-inflammation; this was also consistent with the pathological mechanism of the aforementioned diseases. Moreover, it is worth paying close attention to the potential therapeutic effect of Centella asiatica and asiatic acid on lung cancer. Also, the mechanisms of promoting apoptosis and inhibiting differentiation of tumor cells are worthy of further exploration.
Pulmonary fibrosis can be induced by a variety of injuries to the lung. It is characterized by fibroblast/myofibroblast activation and excessive extracellular matrix accumulation, leading to a progressive organ dysfunction mainly including varying degrees of inflammation and fibrosis. By reducing collagen accumulation, pulmonary fibrosis can be effectively improved through TGF-β1 and NLRP3 pathways and decreasing the levels of inflammation factors.
Chronic Obstructive Pulmonary Disease (COPD):
Chronic Obstructive Pulmonary Disease is a frequently progressive inflammatory disease of the respiratory tract, alveoli, and microvasculature. The pathological mechanism of COPD is that airway epithelial cell damage triggers nonspecific inflammatory responses by releasing endogenous intracellular molecules or molecular patterns associated with danger. Impaired immune regulation may play a major role in COPD. For the treatment of COPD, it is generally recommended to use appropriate long-acting maintenance bronchodilators and inhaled corticosteroids; pulmonary rehabilitation can also relieve symptoms. However, corticosteroid treatment has certain side effects. Lung cancer is the most common cause of cancer-related mortality in the world. Different treatment methods for lung cancer are generally selected according to the stages, such as surgery, radiation therapy, molecular targeted therapy, and immunotherapy.
Acute Lung Injury (ALI):
Acute lung injury is a systemic inflammation of the lungs manifested as hypoxia, edema, and pulmonary infiltrates present in the chest cavity. Acute lung injury is characterized by epithelial and vascular permeability increased, hypercoagulation and insufficient fibrinolysis, and inflammation and immune regulation.
Cold and Asthma:
Centella asiatica extract mixed and soaked with long Pepper air-dried and powdered. For cold and fever, 1 gram of this powder mixed with honey is taken two times a day. Cleaned leaves of Centella with tea cures asthma, cold and fever.
Grind equal amount of Centella asiatica leaves with Pepper, and Tulsi leaves and make into pills and dry and store. Take these pills during a fever helps you to recover fast.
A study on Airline Flight Microangiopathy showed significant improvements in microcirculatory function in those utilizing TTFCA (triterpenoid fraction of Centella asiatica) with edema and rate of ankle swelling approaching normal values.
Take 60 to 100 mg of Gotu Kola extract thrice a day for seven days before and after the flight. You can make a cream by adding 1% Gotu Kola extract with other herbs to apply to the affected area to get rid of swelling.
Gotu Kola enhances antioxidant enzyme like glutathione level and also improve catalase levels. Along with this, a significant reduction of malondialdehyde has also found. It also showed that Gotu Kola reduces lipid peroxidation with spontaneous motor activity. Gotu Kola has also been found to have antioxidant properties. This means that extracts made from Gotu Kola could be used to prevent inflammation, and slow down damage of the cells. This also means that it has potential for use in the treatment of cancer, but more studies need to be done regarding its effectiveness.
A 2008 study in rats "Efficacy of Centella asiatica in Reducing Oxidative Stress in Hydrogen Peroxide-induced Sprague Dawley Rats" published in Masters thesis, Universiti Putra Malaysia by Hussin, Mahanom showed no toxic effects to the heart, liver and kidney on long term consumption of Centella asiatica extract. Results also showed Centella asiatica extract and powder may ameliorate H2O2-induced oxidative stress by increasing HDL concentration, decreasing TG, LDL, lipid peroxidation. Effects are attributed to antioxidant components and polyphenols substances present.
A 2007 study "Protective effect of Centella asiatica extract and powder on oxidative stress in rats" published in Food Chemistry Vol 100, Issue 2 showed Centella asiatica extract and power may ameliorate H202-induced oxidative stress by decreasing lipid peroxidation.
The antioxidants of Gotu Kola benefits the body by aiding in fighting free radicals in the body, improve skin health, and enhance cognition. Gotu Kola protects the brain from the harmful effects of free radicals. Free radical damage, also known as oxidative stress, occurs when unattached oxygen molecules attack cells, in much the same way that these molecules attack metal, causing it to rust. Antioxidants neutralize damaging free radicals, rendering them harmless.
Modulation of Genotoxicity:
A 2011 study "DNA-protective effect of extract/fractions from Centella asiatica (L.) Urban in single cell gel electrophoresis assay" published in Spatula DD. by Tejpal Gill, Manish Kumar, Subodh Kumar, Satwinderjeet Kaur. evaluated an aqueous methanolic extract and various fractions against hydrogen peroxide (H2O2) induced DNA damage. Results showed potent dose-dependent genoprotective activity. Centella asiatica showed to be a strong modulator of genotoxicity caused by oxidative mutagen and presents a potential for use in chemopreventive trials.
Another 2009 study "Effect of Centella asiatica L. extract against ethinylestradiol induced genotoxic damage on cultured human lymphocytes" published in Biomedical Research: An international Journal of Medical Sciences by Yasir Hasan Siddique, Tanveer Beg, Mohammad Afzal evaluated the effect of Centella asiatica extract against genotoxic doses of ethinylestradiol on human lymphocytes culture. Results suggest Centella asiatica extract reduced genotoxic damage during ethinyl- estradiol therapy in patients, thereby reducing the chances of cancer development in humans.
Extracts obtained from Centella asiatica have also been found to have a bacteriolytic effect.
In an experimental animal study done in 2012, it was seen that the application of different extracts of Centella asiatica could inhibit the growth of bacterial colonies in wounded or irritated skin.
A 2009 in Bovine Mastitis study "Antibacterial Activity of Crude Extracts of Centella asiatica against Staphylococcus aureus in Bovine Mastitis" published in Kasetsart Veterinarians vol. 19 No. 3 by Duangkamol Taemchuay, Theera Rukkwamsuk, Thavajchai Sakpuaram and Nongluck Ruangwises, evaluated crude ethanol or water extracts for in vitro antibacterial activity against 30 isolates of Staphylococcus aureus from milk samples of dairy cows. Results showed antibacterial activity with the ethanol extracts showing more potential antibacterial activity against Staphylococcus aureus than the water extracts. Results suggest testing in an in vivo study.
"A study on antibacterial activity of crude extracts of asiatic pennywort and water pennywort against Staphylococcus aureus" published in KMITL Sci. J. Vol 8, No 2, by Duangkamol Taemchuay et al. about crude water extract of Asiatic Pennywort, particularly extracted with water, showed promising antibacterial effect against Staphylococcus aureus.
An in vitro study of the effect of Centella asiatica (Indian pennywort) on enteric pathogens published in Indian J Pharmacol Vol 36, Issue 1 in 2004 on the effect of Centella asiatica on enteric pathogens. The alcohol extract was bactericidal against V cholera, Shigella spp, and Staph aureus and suggests further studies in its potential as an antidiarrheal drug.
A 2009 study "Antimicrobial and Antifungal Activity of Centella asiatica (L.)Urban, Umbeliferae" published in Research J. Pharm. and Tech.2 by NS Jagtap, SS Khadabadi, DS Ghorpade, NB Banarase, SS Naphade evaluated the antimicrobial activity of various extracts against selected strains, viz., P. vulgaris, S. aureus, E. coli, B. subtilis, A. flavus, A. niger, and C. albicans. Results showed the ethanolic extract to have higher antimicrobial activity than petroleum ether and water extract.
An in vitro study of the effect of Centella asiatica (Indian pennywort) on enteric pathogens published in Indian J Pharmacol., February 2004, Vol 36, Issue 1 by B. Mamtha, K. Kavitha, K. K. Srinivasan, P. G. Shivananda demonstrated the antimicrobial activity of Centella asiatica against enterophathogens. Broad spectrum activity of the herb was observed against a range of enteric pathogens. Against V cholera, Shigella species and S aureus, the alcoholic extract was bactericidal within 2 hr.
The antibiotic property of Gotu Kola speeds up wound healing. It further improves blood flow and strengthens veins and capillaries. It effectively reduces fever and dysentery in children.
Gotu Kola protects our immune system from toxins. A few illnesses that Gotu Kola can treat incredibly are high blood pressure, heart failure, urinary tract infection, and venereal diseases.
A study "Immunomodulatory Activities of Centella asiatica and Rhinacanthus nasutus Extracts" published in Asian Pacific J Cancer Prev. 6 by Khanittha Punturee et al. revealed immunomodulatory activity of Centella asiatica and R nasutus extracts in both non-specific cellular and humoral immune responses. Results suggest a chemoproventive or anticancer potential.
"An in vitro study of Effect of Centella asiatica on Phagocytosis by Human Neutrophils" published in International Journal of Pharmaceutical Sciences and Nanotechnology, Volume 1, Issue 3 by Ravindra G. Mali, and Basavraj C. Hatapakki investigated the effect of an ethanol extract of leaves on neutrophil phagocytic function. Centella asiatica extract stimulated chemotactic, phagocytic, and intracellular killing potency of human neutrophils. Results showed Centella asiatica stimulates cell-mediated immune system by increasing neutrophil phagocytic function.
It has been theorized that the potent antioxidant effects of Gotu Kola may have a positive effect on the immune system and help in reducing disease risk. In addition, Gotu Kola contains asiatic acid, which has been proven to induce apoptosis (spontaneous cell death) and inhibit cell growth activity in certain types of cancer cells, including liver, breast, skin, brain, and gastrointestinal tumor cells. Because of a few unapproved claims and exaggerated that say Gotu Kola can treat all the diseases from mental illness to cancer, the actual value and benefits of Gotu Kola in treating disease have been shrouded.
Promotes Relaxation and Alertness:
Natural healers and researchers debate whether Gotu Kola is a true adaptogen (a tonic herb that helps balance the body by supporting its ability to deal with physical and emotional stress). Tonic herbs are traditionally taken on a daily basis over a long period of time, as opposed to herbs that are only used on an as-needed basis. In any case, Gotu Kola has a long tradition of use as a tonic herb for promoting longevity, vitality, and equanimity. It was found to be one of the most useful herbs to help people feel energized, alert, and relaxed. Gotu Kola is one of the safest remedies for easing stress and anxiety. Tonic herbs are traditionally taken on a daily basis over a long period of time, as opposed to an herb that is only used as needed. In any case, Gotu Kola has a long history of usage as a tonic herb for promoting longevity, vigor, and equanimity. Folklore tells of a Chinese herbalist who lived to be more than 250 years old, because of routine use of this natural plant medicine. Legend says he retained his youthfulness and health, while outliving 23 wives, after ingesting Gotu Kola every day. Some people refer to Centella asiatica as “The Fountain of Life”.
In a placebo-controlled study, subjects who ingested a single 12-gram dose of Gotu Kola had significantly reduced startle responses in just 30 minutes, proving this herb’s anxiety-reducing activity.
In one 2008 placebo-controlled study, subjects, each approximately 65 years old, who took daily Gotu Kola capsules for eight weeks showed an increase in alertness and calmness, which in turn improved attention and working memory.
This Ayurvedic herb is used for hair as well as for getting health benefits. It is helpful in reducing the problem of hair loss. Some studies suggest that using Gotu Kola can increase hair length and decrease their fall rate. It is used for the growth of healthy hair i.e. enhances the beauty of hair by acting on the hair follicle region. The benefits of this herb also include improving the texture of your crowning glory because it strengthens blood vessels and boosts blood circulation. This results in healthy skin and scalp. Massages with gotu kola hair oil prevent hair fall, dullness, and premature greying. This herb gives stronger, thicker, and longer hair. It helps to stop hair loss and prevents graying of hair.
Take the equal proportion of Gotu Kola juice and coconut oil. Now, boil the mixture followed by cooling it. After making it cool, massage your scalp with the mix. Massaging the scalp prevents drying of it and also enhances your mental awakening. It is good to combat stress and free radicals, which are not good for hair health.
Gotu Kola is very famous for the treatment of hair loss. This herb also acts as a platform for hair re-growth. Hair loss happens when the hair follicles become weak due to malnourishment. This herb plays a very important role in strengthening the hair follicles and nourishing the scalp. It strengthens the blood vessels in the area and allows the small hair follicles to expand.
Both internal consumption and external application of Gotu Kola is very good for promoting hair growth and for preventing hair loss. The best way to use Gotu Kola for hair externally is by applying Gotu Kola oil. Gotu Kola oil can also made at home by infusing dried leaves in cold pressed oil by heating it under sunlight. To make the oil, collect fresh Gotu Kola leaves, wash them well and sun dry them well till crisp. Now take the leaves in a glass bottle, add virgin coconut oil and heat it again under sunlight till the Gotu Kola extract is infused into the oil. This oil can be used to massage the scalp. You can also take Gotu Kola tea along with applying Gotu Kola oil on the scalp for best results. Studies suggest that its effect are greatly improved when combined with Holy Basil (Tulsi) and Amla, which is just why we have formulated all of them in a Ultra Luxuriant Hair Elixir.
In the realm of beauty, its main benefit is its ability to prevent hair loss. It stimulates microcirculation, which enables greater oxygen and nutrient intake by the follicle, thereby enriching its growth. Aside from lowering stress levels, Gotu kola also reduces free radicals, which are known to be the cause of hair loss. Just apply a mixture of Gotu Kola, Amla, Holy Basil, False Daisy, and Aloe Vera to achieve a healthier hair growth.
If you have Gotu Kola powder at home, you can make a very effective hair mask with it. To make Gotu Kola hair mask, combine fresh Aloe Vera gel along with Gotu Kola powder and mix into a paste and use it as a hair mask, this mask will prevent hair fall and treat all scalp infections.
Gotu Kola is safe for pets when given in doses appropriate for their size. In veterinary natural medicine, Gotu Kola has been showing good results when used for pets for a more natural approach. Gotu Kola has chemicals known as triterpenoids that help to reduce anxiety and stress and also helps cognitive function. Because it is high in antioxidants, this powerful herb is also used to help treat heart conditions, epilepsy, and joint disorders like arthritis (reduces muscle and joint inflammation). Another ability that Gotu Kola has is wound healing. It is high in collagen and helps to improve skin health and to soothe numerous nervous disorders. It can also be used as a tonic, which helps to balance hormones.
Gotu Kola is used in herbal supplement blends for pets:
- BK-Detox: Is a supplement that supports a healthy immune system and detoxification. Gotu Kola is included in this blend helps to improve circulation, promotes strengthening of the blood vessels, and supports detoxification of the blood.
- Felimm: Is formulated to help fight viral and bacterial infections, and promote detoxification of the lymphatic system. Gotu Kola is used in Felimm for its immune system strengthening and antioxidant properties which help the body to fight off potential infections.
- Resthyro: Has been formulated to help pets with hyperthyroidism. Resthyro supports balanced thyroid activity and can help with symptoms associated with an overactive thyroid gland. Gotu Kola a part of this blend as it helps with inflammation and balancing hormones, including thyroid hormones.
- Thyro-Up: Is a herbal formula to support pets with hypothyroidism. Thyro-up helps promote balanced thyroid activity for an underactive thyroid gland and the symptoms associated with it. Gotu Kola is part of this blend for its anti-inflammatory and hormone-balancing properties.
It is suggest using it only when formulated by veterinarians and correctly dosed for your beloved furbaby. Supplements should be vet-formulated with the help of a master herbalist.
A 2005 study "Larvicidal and Adult Emergence Inhibition Effect of Centella asiatica Brahmi (Umbelliferae) against Mosquito Culex quinquefasciatus Say (Diptera : Culicidae)" published in African Journal of Biomedical Research, Vol. 8, where crude extract of leaves of Centella asiatica showed larvicidal and adult emergence inhibition against mosquito Cules quinquefasciatus, possibly through various biologically active compounds–phenolics, terpenoids and alkaloids.