Eleuthro (Eleutherococcus senticosus or Acanthopanax senticosus), also commonly known as Siberian Ginseng, is a small, woody shrub belonging to the Araliaceae plant family. Siberian Eleuthero is a flowering shrub growing to 9 feet tall native to the southeastern part of Russia, northern China, Korea and Hokkaido, Japan’s northern. Eleuthero root and rhizomes (underground stem) are the part of the plant that people use medicinally. Soviet cosmonauts and olympic athletes have used it, the German government endorses it. It’s said to improve stamina, performance, endurance, reflexes, and concentration. Siberian Ginseng isn’t really a Ginseng, but it’s a natural for boosting athletic performance, and it combats stress as well. If you ever come across the term “eleutheromania”, it’s not a reference to an obsession with eleuthero root. Eleutheromannia actually means “a manic yearning for freedom”. So it has nothing to do with this quite impressive herbal remedy.

Eleuthero is not related to American ginseng (Panax quinquefolius) or True Ginseng (Panax Ginseng). The word Ginseng is of Chinese origin and means “the essence of earth in the form of a man”. For Chinese medicinal plant diggers, the word seng refers to any nonwoody, fleshy rootstock used to make a medicinal tonic. Eleutherococcus (from Greek) means "free-berried", and senticosus, from the Latin word sentis "thorn-bush, briar" is an adjective meaning "thorny" or "full of briers or thorns". Traditional Chinese Medicine (TCM) recognizes only one True Ginseng, known as either Panax ginseng or Panax quinquefolius (North American Ginseng). Both are members of the Araliaceae, or Ginseng, family, which includes more than 800 species and is composed mostly of tropical trees, shrubs, and vines. But it has played an important role in TCM for at least 2,000 years: its root bark has been used to create an herbal drug known as cì wǔ jiā (刺五加), which is used as a tonic and appetite enhancer and to relieve lower back and kidney pain, among other purposes.

Eleuthero became known as Siberian Ginseng during the late 1960s and early 1970s, when extracts of its root were first marketed in the United States. Some contend that labeling this herb a Ginseng was the result of a marketing campaign to capitalize on the emerging popularity of ginseng, rather than to provide an accurate description. Members of the American Herbal Products Association suggest that Eleuthero is the more appropriate name. Nevertheless, the name Siberian Ginseng has stuck. Eleuthero is a relative of Ginseng. It grows in the same Asian regions and has similar effects. But true ginsengs are more prized for their better-researched health effects. True Ginseng is also much more expensive than eleuthero. Today, Eleuthero is sometimes used as a cheaper, though potentially less effective, Ginseng replacement.

The efficacy of Eleuthero was extensively studied in the former USSR, where scientific research assessing its effects dated back to the 1950s. Eleutherococcus root extract was approved by the Soviet Union Pharmacological Committee for clinical use as a stimulant in the early 1960s and was recommended for use in the Soviet space program to improve adaptability to the harsh and stressful conditions of space. Most research on the adaptogenic effects of Eleutherococcus senticosus was conducted between the 1960s and the 1980s in the USSR. Although there were some flaws in those studies, the vast amount of research and large number of subjects included in those studies, along with reported uses of Eleuthero in the USSR, indicate compelling evidence of adaptogenic, anti-fatigue, and physical and mental performance-enhancing effects. They called this ability “adaptogenic”, a term coined in 1947 by a Russian scientist to describe substances that increase resistance to adverse influences. Adaptogens do so in nonspecific ways, modulating stress and improving performance under a wide variety of stressful conditions while causing little disruption to the body. Siberian Ginseng is popular among factory workers, athletes, miners, soldiers, deep sea divers and other individuals who engage in physically and mentally demanding tasks and occupations. A few recent studies have confirmed those effects. Soviet findings were later replicated by other researches and Eleuthero root extract has been adopted for medicinal use in several countries besides Russia. Eleutherococcus senticosus is included in the European Pharmacopoeia.

[Note: The vast majority of the early studies on Eleutherococcus senticosus were published in Russian with no available English translations. However, they have been summarized in several review articles or books published in English. Data on the results of older Russian studies mentioned in this article were obtained from those books and articles or from monographs published by governmental agencies].

Eleuthero or Siberian Ginseng is a herb that has been used in traditional folk medicine to manage stress, mental and physical fatigue, energy depletion, depression, anxiety, and insomnia. Eleuthero is regarded as an adaptogenic herb, it increases non-specific resistance to different kinds of stressors, promotes well-being, and enhances physical endurance. It has stimulating and tonic effects, meaning that it can increase work capacity (stimulating effect) after a single dose and that its stimulating effects can be maintained for a sustained period of time after a period of continued intake (tonic effect). Research indicates that Eleuthero increases the body’s stress defenses, immune defenses, anti-inflammatory defenses, and, most notably, antioxidant defenses. Eleuthero was shown to well tolerated and have protective effects in several organs and systems, thereby indicating a general beneficial effect, include its ability to help relieve stress, increase cognitive function, boost the immune system, reduce fatigue, reduce inflammation, protect heart health, prevent degenerative diseases, improve respiratory health, and increase energy levels.

Studies of Eleuthero’s effects on human performance show that the plant increases human tolerance to a broad range of stress factors, including heat, noise and increased exercise. When taken regularly, the extract of the root increases work output, endurance, athletic performance and mental alertness. The plant also shows remarkable protective benefits under conditions of serious oxygen deprivation. Due to its stress-reducing and extraordinary performance-enhancing powers, Unlike many other invigorating plants, Eleuthero also shows value as a sleep aid. In clinical experiments, extracts of the plant have been proven to shorten the time it takes to fall asleep, while increasing the depth and duration of sleep. This may be due to the plant’s ability to reduce stress hormones in the blood. As a result, Eleuthero extract is the primary ingredient in some of China’s most popular sleep aids.

There is evidence that Eleuthero was first used as an herbal remedy in China some 2,000 years ago. The plant is mostly used in traditional medicines as an adaptogen, a compound that helps the body better handle and adapt to stress. Listed in the Chinese Pharmacopoeia, Eleuthero is one of the best documented plants in herbal medicine. Extensive studies conducted in China and Russia, compiled at the Harbin Research Institute, show that consumption of the root and its preparations enhances immunity, increases strength, stimulates sexual function, improves sleep, helps the body during times of oxygen deprivation, enhances cardiovascular function, improves overall athletic performance, and sharpens mental alertness. Probably more than any other herb studied, Eleuthero demonstrates the capacity to improve all aspects of human performance.

Eleutherococcus senticosus contains several compounds that have shown pharmacological effects in medically and scientifically validated tests and assays. The main bioactive ingredients of Eleuthero are called eleutherosides and are found in highest concentrations in the root of the plant. Eleutherosides are the main components of eleuthero that have potential health benefits. There are seven primary eleutherosides in eleuthero, with eleutherosides B and E being the most frequently studied. Additionally, two polysaccharides in the plant display specific immune-enhancing power by promoting phagocytosis, when protective cells engulf harmful microorganisms, damaged cells and foreign particles. The polysaccharides also help with the promotion of protective B lymphocytes. Further studies show that Eleuthero helps to defend the body against some bacterial and chemical toxins. This makes it an ideal supplement for urban dwellers. Other bioactive compounds found in Eleuthero include phenylpropanoids, lignans, triterpenoid saponins, coumarins, flavones, vitamins, and provitamins.

One of the most important benefits is its effect on your immune system. Historically, this has been one of the main reasons people used Eleuthero, and recently, studies have backed this up. Boosting your immune system does more than just prevent illness. It may also help prevent ulcers, reduce respiratory tract infections, and even heal wounds. Siberian Ginseng has been shown to have immune-boosting benefits that can benefit healthy individuals as well as those undergoing treatment for cancer or those with HIV/AIDS and Hepatitis C hence enhances immune system function. It also prepares the activity immune system compounds B- and T-cells to attack bacteria and provide protection during radiation. When tested in an animal study, the root extract of Eleuthero was found to increase the levels of antibody molecules IgG and IgM which are responsible for protecting the body against microbes. Also, by supporting natural detoxification processes of the liver, Eleuthero has also been found effective in helping the liver process harmful toxins, including sodium barbital, alcohol, and tetanus toxin. Regular use of Siberian Ginseng helps to prevent and treat viruses, infection and disease. It contains chemicals that enhance one’s immune function and make you more resistant against common bacterial and viral strains.

The eleutherococcus senticosus has a series of bioactive compounds (eleutherosides) which help to regulate the homeostasis. It can stimulate the immune system and increase the levels of hormones activated by stress. Consequently, this plant can improve our ability to deal with environmental stressors. Its activity appears to be based on whole body effects, rather than particular organs or systems, which lends support to the traditional view that Ginseng is a tonic that can revitalize the functioning of the organism as a whole.

The faster recovery time you could see as an Eleuthero benefit for exercise can also support your immune system and speed up the healing process. Eleuthero has many benefits that support the immune system. Your immune system may be charged through increased immune cell production. Your immune system is very complex with many functions and Eleuthero benefits many of these functions. Specifically, Eleuthero has antioxidant properties, boost liver function, has anti-viral, anti-cancer and anti-tumor properties.

Research has shown that Eleuthero can boost the immune system so making you less prone to colds and flu. It would seem to be stronger than true Ginseng in this regard. It is used as is Skullcap and American Ginseng to relieve stress, in the form of a tisane. One of the many research studies on the health benefits of eleutherococcus revealed that it can significantly boost the immune system when taken in combination with other immune-enhancing herbs, can reduce the severity and duration of colds when taken early in the disease. This can be accomplished through a supplemental form or by regularly drinking Eleutherococcus tea. Many human studies have demonstrated that Eleutherococcus root extract, given prophylactically, can stimulate and modulate the immune system, reduce the overall disease incidence, and increase resistance to infections and its complications. Eleuthero was shown to support cellular defense mechanisms, decrease DNA damage in lymphocytes, and promote immune cell activity.

According to research, this type of Ginseng could increase the lymphocytes which are the main defense of our body against infections. Some researchers believe that it can also increase the biosynthesis of interferon (a powerful chemical that stimulates the immune system). Others believe that its success is due to its natural polysaccharides (long chain sugar molecules). These elements stimulate the activity of special white cells called macrophages. One of their main tasks consists of breaking down infected cells and stimulating other immune cells.

Immunomodulatory:

Another important action of an adaptogen is immunomodulation, a process by which an immune response is altered to the desired level. This is partly achieved by recharging exhausted adrenal glands - when these glands become over-taxed leading to different systems in the body to break down. Siberian Ginseng consists of a group of glycosides known as eleutherosides. The evidence is mounting that Siberian Ginseng enhances and supports immune system response, making it a possible natural alternative in the long term management of various diseases of the immune system.

The jury is still out as to how Siberian Ginseng achieves this powerful effect on the immune system, with some researchers believing it induces increased interferon biosynthesis (interferon is a powerful chemical which boosts immune-system activity). A direct consequence of the previous point is the immunomodulation. In other words, the stimulation of the immune system. This fact is connected to the functioning of the adrenal glands. On the contrary, they could become saturated when facing a stressful situation.

Improves Quality of Life for the Elderly:

Other types of Ginseng come with a lot of side effects that can be a bit too much for the elderly to handle. However, Siberian Ginseng has been reported to have milder effects.

However, it’s not a long-term solution as the study also revealed that these improvements these differences continuously diminish with continued use. Use Siberian Ginseng on a less regular basis rather than making it an every day ritual.

Enhances Physical Activity:

As a stimulant, Eleuthero may increase the ability of muscles to do work, especially during periods of intense physical activity. The eleutherosides, active chemical compounds in eleuthero minimize the activity of the adrenal cortex, hence block stress responses. It is a stimulant which boosts immune function and as a result combats infections that arise during vigorous physical exercises.

Like many adaptogens, Eleuthero benefits can enable your body to better control physical stressors. When you increase the ability of muscles to do work and handle intense physical activity you improve your endurance. Additionally, Eleuthero can reduce exercise-induced immunosuppression and exercise-induced serotonin release. Therefore suppressing these chemicals can make exercise less taxing and can reduce the required recovery times. As we discussed above, your mind may fail you before your body does and Eleuthero can reduce the mental and physical fatigue from exercise. Similarly, you may find Eleuthero in workout supplements and that is because athletes have seen increased performance through increased endurance, heart rate, and lower glucose levels in the blood. You may also see improved blood flow that can benefit you with improved endurance and faster recovery time.

The use of the herb not only raised energy but also boosted metabolism, increased endurance, and supported healthy heart function in response to exercise, overall enhancing physical performance in these subjects. The study was double-blind and placebo-controlled, demonstrating in no short terms that it was Siberian Eleuthero that was responsible for these benefits.

More recent studies on physical performance have also shown that Eleuthero may be able to improve endurance performance, cardiovascular function, and recovery in healthy athletes or recreationally trained individuals. However, there have also been studies in which Eleuthero failed to produce beneficial effects on physical performance.

Improves Athletic Performance:

Eleuthero has the potential to increase endurance and time-to-exaustion, by acting similar to caffeine, which is by suppressing exercise-induced 5HT synthesis and TPH expression. When we exercise, levels of serotonin slowly increases, especially in the mid-brain, suppressing the immune system. That consequently decreases (dopamine) neural activity which extends or increases recovery time. As a stimulating adaptogen, eleuthero can improve energy levels and stamina.

There is evidence which supports Eleuthero effects in increasing endurance, through increased FFA production, and decreasing glucose levels. It does this by altering the metabolism for sparing glycogen, enabling a more efficient way of producing energy. It was also shown to shorten recovery time in a mice swimming test, increasing fatty acid B-oxidation in skeletal muscle. Eleuthero may also improve cardiovascular ability through increasing oxygen metabolism uptake and maximal oxygen pulse.

In human athletes, Eleuthero improved several markers of performance. It increased the amount of time each athlete can maintain an effort; it increased maximum heart rate, a measure of exercise intensity; it decreased glucose and increases free fatty acids in the blood during exercise. As a result, Eleuthero may improve a process called glycogen sparing: shifting your fuel from carbs to fats.

Studies in athletes have revealed that Eleuthero is capable of increasing performance by prolonging endurance time, decreasing blood glucose levels, and increasing heart rate. It also reduces exercise-induced immunosuppression and exercise-induced serotonin release. These are two factors that make exercise more tasking and can prolong recovery time after exercise. Energy-boosting has obvious value to the average athlete. But according to research, there’s a bit more to Siberian Eleuthero and boosting athletic performance than simple energy.

Siberian Ginseng can improve the overall health and functional of your cardiovascular system, including lowering blood pressure, increasing circulation, and decreasing overall cholesterol. Although it helps to increase blood flow to certain parts of the body, it also widens the blood vessels so more blood can flow with less strain on the arteries and vessels. It also helps to decrease and balance cholesterol levels in the body, thus lowering the chances of suffering from atherosclerosis, as well as the peripheral conditions, like heart attacks and strokes, that so commonly follow. In fact, many of the benefits you can see from Eleuthero may be contributed to the increased blood flow produce by Eleuthero. Notably, your memory and your immune system benefit from increased blood flow, along with muscle endurance. Especially if you suffer from low blood pressure or at risk for hypertension you may see benefits from Eleuthero. Additionally, when you think about heart health, you likely think of reducing cholesterol. Eleuthero may also help you cut down your high cholesterol and weight gain from high cholesterol diet.

Blood Circulation:

Blood flow is vital for mental functions such as memory, alertness and concentration. Eleuthero is useful in promoting proper flow of blood to the brain.

Increasing Blood Pressure:

Eleuthero is considered a natural stimulant. Herbal stimulants like Ashwagandha, caffeine, Panax ginseng, eleuthero can boost energy levels and protect mental function. As a stimulant, Eleuthero increases circulation and heart rate, and may raise blood pressure over time. This may be beneficial for people with low blood pressure, but can cause risks for people with hypertension. People who suffer from low blood pressure (hypotension) experience dizziness and fainting spells, and just like high blood pressure, hypotension can be life-threatening in severe cases.

Cholesterol Levels:

We all understand the importance of maintaining cholesterol levels. While it can become a bit difficult to do so for a lot of people, Siberian Ginseng can help them. It has been found that this medicinal herb can help in lowering blood sugar levels. That can be extremely beneficial for people with Type 2 diabetes. In fact, you can take Siberian Ginseng extract powder alongside most medications that are used for sugar control. However, it is always better to first consult your doctor before you take this extract.

Eleuthero may help cut high cholesterol.It has been found in studies to be effective in reducing level of cholesterol in the b body. It combats biological processes that lead to oxidative stress, thereby safeguarding the body from cardiovascular conditions such as stroke as well as cancer.

Increases Brain Functions:

The brain is part of the nervous system, along with the spinal cord, nerves, and sensory organs. The nervous system responds to chronic stress in multiple ways. Some people may develop stress headaches, and others suffer from insomnia, anxiety, or depression. Over long periods of time, cortisol can cause neuro-inflammation and elevated cortisol levels have been linked to increased risk of migraines and depression. Research indicates that high cortisol levels also promote degeneration and death of nerve cells along with decreased memory function.

You may see improve mental functions such as memory and concentration when as an Eleuthero benefit. Consequently, you may notice your improved mental capacity by improved recall and memory. Specifically, some people feel a similar mental sharpness when taking Eleuthero as they do with caffeine from coffee. Additionally, People are taking Eleuthero for its neuroprotective properties to combat effects of diseases such as Parkinson’s and Alzheimer’s. You may be suffering from age-related memory impairment, this can be brought on by oxidative stress which adaptogens like Eleuthero can help combat. The antioxidant action of eleuthero could help reduce memory impairments through this mechanism as well.

Eleuthero is beneficial for mental energy as well as physical energy. It can help your alertness and focus improve and may also help with memory and learning. This is thought to happen because eleuthero root increases oxygenation and improves circulation to the brain. These properties along with its anti-stress and anti-fatigue effects can really give you a mental boost.

Neurological Disorders:

One of the most tragic diseases we face as a world population is Alzheimer’s; gradual memory degradation can be a painful and unbearable situation. Eleutherococcus benefits help eliminate many of the free radicals that accumulate in the brain and cause plaque formation, this can help keep neural pathways clear, improve memory retention and recovery, and slow or stop the progression of Alzheimer’s disease.

Neuroprotection and Neuroplasticity:

Eleuthero can be beneficial for our cognitive process not just as memory and focus, but it can also improve the brain’s ability to adapt or change. This is one of the primal reasons why it helps with transitions like climate change or job change. Adaptogens enable us to cope better with stress. Shown to act as AMPK activator which plays role in cellular energy homeostasis and can activate glucose and fatty acid uptake and oxidation when there is low cellular energy. Eleuthero also acts as a BDNF modulator, useful for CNS diseases, which enhances brain ability to adapt, also known as neuroplasticity.

This plant can be beneficial and support neuroprotection on isoflurane-induced cognitive dysfunction, plus, it reduced hippocampal neural death in the CA1 region in mice and stimulated spatial memory recovery. There are also other brain-related and cognition-enhancement effects from eleuthero, research shows. Eleuthero may improve cognition and have beneficial effects in many areas such in mental performance such as improved attention, speed, and accuracy under stressful cognitive tasks in tired individuals. By helping to recycle choline more effectively, eleuthero may have the potential to improve its synthesis, thus improving cognitive function.

Phyto-adaptogens, like Rhodiola, Panax Ginseng, and Eleuthero all have neuroprotective features. They have been shown to protect brain neurons and are proposed for use as therapeutic modulators in neurodegenerative disorders including Parkinson’s disease.

One of the main neuroprotection nootropics is Eleuthero. Neuroprotection is protection from amyloid plaque, oxidative stress or other brain-aging factors. The power of eleuthero lies in its ability to reduce inflammation.

Increases Energy:

More than anything, Siberian eleuthero is best known as a powerful source of fuel and energy to stop tiredness in its tracks. Siberian eleuthero is becoming popular that it’s now an addition to natural energy drinks. Siberian Ginseng is popular for stimulating and fortifying the body. It helps to boost energy levels in people with persistent tiredness. Those recovering from an illness or weary from a heavy work schedule may also benefit from its energy-boosting and immune-enhancing powers.

Besides protecting the body from stress, Siberian Ginseng also increases oxygenation of the cells, thereby increasing endurance, alertness and even visual acuity. This increased oxygenation leads to better circulation, especially to the brain, helping to restore memory, concentration and mental clarity. You may be considering Eleuthero as an alternative stimulant to caffeine. As a stimulant, Eleuthero boosts energy levels and contains compounds known to help overcome exhaustion and prevent its side effects. Though you won’t get the immediate stimulant response you may be accustomed to with caffeine. The energy boost you will likely get from Eleuthero is more consistent with increasing endurance energy. But, energy levels are not all physical, you may feel mentally exhausted long before you feel physically exhausted. For that reason, you may have more of an energy boost from your improve mental capacity than your physical endurance.

Many studies have helped uncover and support this, including this major review, citing energy-boosting effects from the herb following aerobic exercise and due to the metabolic impacts. Because of this, many people seek it out long shift and night workers, hard laborers, and most notably these days, with its increasing popularity, athletes. Eleuther is a favourite supplement for professional runners, Siberian Ginseng delivers a powerful energy boost. It is so popular that it’s hard to find any runners who do not take it before a race, simply because they cannot outrun the other competitors who do use it.

Increases Stamina:

Eleuthero demonstrates an ability to improve physical stamina and mental sharpness similar to caffeine but without an impending crash. Studies to date have had mixed results but some point towards the ability of Eleutherococcus senticosus to boost cardiorespiratory fitness, fat metabolism and overall endurance performance. It's often used as a supplement by professional runners because of its ability to boost energy, stamina, and alertness.

According to the book, Botanical Medicine for Women’s Health, “Clinical findings also have suggested that patients with moderate fatigue in chronic fatigue syndrome may benefit from use of Eleuthero, and that older adults may safely experience improvement in some aspects of mental health and social functioning after four weeks of therapy, although these differences attenuate with continued use".

Daytime Fatigue:

One of the main claims of fame for the benefits of Eleutherococcus is its ability to increase energy levels. This is achieved by its impact on the nervous system, increasing metabolism, increasing circulation, and reducing cloudiness and fatigue. For people who regularly need daytime naps, feel mid-day tired after a big meal, or feel tired without a good explanation, regular eleutherococcus supplementation can bring you back to normal. As a stimulant, Eleuthero boosts energy levels and contains compounds known to help overcome exhaustion and prevent its side effects.

Eleuthero is known to have fatigue-fighting properties and produce lightness when we happen to feel lethargic, exhausted, heavy, or fatigued. It is an adrenal gland tonic, that helps in releasing chi energy. When fatigue shows up, whether through physical or mental exhaustion, it acts on our CNS through serotonin causing internal conditions that prevent further exhaustion. Eleuthero can balance that. Eleuthero can extend time-to-exausting, thus improving one’s physical endurance. It was shown to reduce fatigue by accelerating energy changes through B-oxidation facilitation in skeletal muscles. Siberian Ginseng promotes a health endocrine system by restoring Hypothalamus-Pituitary-Adrenal axis (HPA).This way, it aids in overcoming symptoms such as fatigue and stress.

Anti-fatigue properties of Eleuthero were found to be helpful in preventing physical fatigue while improving recovery time. One of the possible mechanisms that protects muscle tissues and delays exhaustion is the reduction of lactic acid accumulation. Eleuthero was shown to improve performance in individuals with mild-stress related fatigue and increase tolerance to mental exhaustion. It was also beneficial in enhancing attention and mental endurance in situations of decreased performance. One of the regulation mechanism is homeostasis in the HPA axis (Hypothalamus-pituitary-adrenal axis).

These benefits are also found in eleuthero root, and it can act both as a tonic herb and a mild stimulant. This means that it can have an impact on fatigue immediately and will continue to work over time to restore energy. Though good quality human studies are still lacking, it's been confirmed in animal studies that eleuthero can "alleviate fatigue both in physical and mental fatigue".

The most significant benefit of taking organic Siberian Ginseng powder is that it can help you deal with fatigue. If you are experiencing mild, stress-induced fatigue, this extract can be a great way to deal with it. This herb has the ability to increase your energy levels. It does so by stimulating the energizing hormones and enzymes in the body. This helps in managing the symptoms associated with fatigue.

Many people who supplement with eleuthero do so for its energy-boosting effects. Eleutherosides activate AMPK, which speeds up the metabolism and breaks down fats to produce energy. Eleuthero may also activate BDNF, which increases the brain’s ability to grow and adapt to change. In human and animal studies, eleuthero supplements increased endurance and mental focus and decreased fatigue. As per a research review published in Current Clinical Pharmacology, eleuthero can help in improving mental performance in people with stress-induced fatigue.

Chronic Fatigue Syndrome (CFS):

Chronic fatigue greatly affects quality of life and is a common reason for many to consult a doctor. Since conventional therapy is often of limited help, fatigued patients often resort to trying herbal treatments. Siberian Ginseng has been tested on patients of chronic fatigue,

Natural Adaptogen:

Rumour has it that Siberian Ginseng was the first ever herb to have the term “adaptogen” applied to it. Eleuthero belongs to a very special category of healing plants. What are adaptogens? They are plants that are able to help balance, restore and protect the body. Adaptogens are a unique group of herbal ingredients which help your body adjust to stressful circumstances, ranging from extreme heat or cold to infections or trauma. This is specially useful when facing unfavorable circumstances in terms of stress. Therefore, our body “will be able to adapt” and succeed in its task despite the circumstances. The dried roots and rhizomes of Eleutherococcus senticosus (Araliacaea) plant are used in various preparations, primarily for its "adaptogenic" properties. An adaptogen supports health and prevents disease in both sick and healthy individuals through nonspecific effects, which neutralize various environmental and physical stressors while remaining relatively safe and free of side effects.

In general, adaptogens like Eleuthero are excellent at helping your body handle stress, whether its physical, chemical or biological. This is very significant since chronic stress is known to contribute to so many health concerns, including the common cold, weight gain, heart disease, sleep problems, depression, ulcers, digestive issues, an impaired healing ability along with back/neck/shoulder pain.

Adaptogens have multiple effects on nervous system and brain health. They normalize neurotransmitter levels in the brain, inhibit cortisol-induced neuro-inflammation, and upregulate neuropeptide Y (NPY). High levels of NPY are found in the amygdala and hypothalamus areas of the brain that are essential for regulation of emotions and our response to stress. Increased NPY reduces anxiety and inhibits sympathetic activity, which slows the heart, reduces blood pressure and decreases cortisol production by the adrenal glands. Furthermore, adaptogens have the ability to increase both the amount of mental exercise a person can carry out as well as the quality of that work.

Eleutherococcus is one of those rare herbs that can help your body adapt and change to better handle various stimuli or conditions. For example, the benefits of Eleutherococcus have been shown to improve the user’s response to stress, that is, the way their body responds when they are anxious or upset. The powerful constituents of Eleutherococcus teach the body to handle biochemical situations in the best possible way.

Siberian Ginseng supports the recovery after an exhausting workout or extreme mental effort. Its adaptogen properties are indispensable for those who face highly stressful situations or demanding physical activities. Siberian Ginseng aids in the recovery from strenuous exercise and extreme mental exertion. Its adaptogenic qualities make it a must have herb for those engaged in highly stressful jobs or high energy activities. It is also extremely useful to those working in abnormally high or low temperature environments.

Siberian Ginseng can improve our work capacity, increasing both the short and long term energy. Moreover, it can improve the circulation (vasodilating effect) increasing the oxygenation, specially to the brain. Consequently, it will enhance the alertness, memory, concentration and even mental clarity. If you take Ginseng regularly for two months, you will start noticing its effects. Many students take Ginseng before exam period in order to enhance their memory and stimulate the brain functions.

Those who fight against mild anxiety, nervousness or hyperactivity can benefit from its properties against stress. In addition, Siberian Ginseng is advised to treat psychological disorders like anxiety or depression. An infusion can be specially useful to encourage a state of relaxation regularly or occasionally. Ginseng produces a series of alterations such as improving the mood and feeling of well being.

Eleuthero root is the first known herb to be called an adaptogen, a term coined in 1957 by Russian scientist Nikolay Lazarev. Adaptogenic herbs have a non-specific and normalizing effect on your body, meaning they help it to cope with stress by bringing it back into balance. Adaptogens can help recharge your adrenal glands and also raise your resistance to stress. Animal studies have shown that they can have anti-fatigue, neuroprotective, and antidepressive effects. Like other adaptogens, eleuthero is often recommended to be taken over a period of time to combat the effects of stress.

Stress:

One of the benefits of Siberian Ginseng for which it is most famous is its general effectiveness at helping users manage their response to periods of environmental stress. It is believed to be beneficial for mental, physical, and biological forms of stress. Big transitions at work, a family crisis, athletic challenges, rampant flu and cold protection, and more stressors may all be weathered better with eleuthero. One of the biggest benefits of taking Siberian ginseng extract is that it can help in lowering the stress in your body. This herb is considered to act as an adaptogen. That means it can help in boosting your body’s abilities to fight against stress. This extract can help your body to act to regulate and respond to stress in a proper way. Along with that, it can also help in promoting the release of adrenal hormones. These hormones can help in reducing stress, which is extremely beneficial for people dealing with chronic stress. In addition to this, it is also effective in supporting your nervous system. That helps in restoring proper neurological functioning if you have experienced stress for a long time.

While memory and cognition can certainly have their effects on mental function, nothing taxes the mind more than stress. A stressed mind in and of itself suffers to function in the ways listed above. If that’s the case, then in an indirect (or even direct) way, can Siberian eleuthero help the mind as it deals with stress.

Eleuthero has been found to reduce physical and mental fatigue in response to physical stress in animal studies. The herb has also been associated with reduced stress-related changes in behavior animals that were deprived of sleep. Eleuthero also decreases recovery time from stress in animal studies. In a test subject induced to experience significant stress from high amounts of corticosterone (a stress hormone), the use of Siberian Eleuthero helped protect the nervous system from stress’s effects and lowered anxiety. It also had a mild anti-depressant effect.

In animal studies, Eleuthero increased mental function and decreased the time needed to recover from stressful events such as forced swimming, sleep deprivation, or moving to a new environment. Eleuthero may activate BDNF, which helps the brain adapt to change. Eleutherosides increase AMPK, which boosts energy and helps us keep going when we’re stressed and tired. Sesamin, a less abundant compound, also protects the body against inflammation and tissue damage. Finally, Eleuthero activates HSP70 and increases the body’s resistance to tissue damage. Added together, these effects likely explain eleuthero’s anti-stress effects. This health benefit is somewhat controversial.

Some studies suggest that eleuthero sometimes increases and sometimes decreases the stress response. Others suggest that no anti-stress benefit exists at all. This controversy may be explained by its hormetic effects. Hormesis is an innate enhancement mechanism our bodies carry, it’s when a mild temporary stressor triggers a shift to higher performance. Adaptogens like eleuthero may be mild hormetic stressors. Still, further research will be required to shine a light on whether and to what extent eleuthero supplements are effective at fighting stress. In animals, Eleuthero seems to increase stress resiliance by its hormetic effects, human data are lacking.

According to the University of Maryland Medical Center, the plant is supposed to strengthen the body’s ability to cope with stress, which may also prevent stress-related medical conditions such as heartburn, upset stomach and tension headaches. Since the herb helps to enhance calmness, some participants claim to achieve improved quality of life. People who struggle with mild or occasional anxiety, nervousness or hyperactivity may benefit from these stress-reducing properties. Siberian Ginseng is not, however, recommended as a treatment for psychological conditions such as anxiety disorder or depression. Since warm beverages help to enhance calmness, Siberian Ginseng in tea form may prove beneficial in enhancing relaxation. As for helping with emotional stress, anxiety, and depression, research is unclear. Many researchers believe that more studies are needed to know for sure what Eleuthero does, and how.

Numerous human trials on the adaptogenic effects of Eleutherococcus senticosus have been conducted, many of which between the 1960s and 1980s in the Soviet Union. Many of these studies focused on determining whether Eleuthero could increase the resistance to several different types of physical and emotional stress, and consequently, reduce mental disturbances, such as anxiety, depression, excitability, or insomnia, and improve physical and mental performance in those contexts.

However, it is important to note that many of those early studies were not conducted in accordance with the current standards of adequate scientific rigor, many lacked controls and statistical evaluation, for example. Nevertheless, given the large number of studies carried out between the 60s and the 80s, the large number of subjects included in those studies, and the contexts in which Eleuthero was recommended and used in the USSR, it seems that the evidence of adaptogenic effects was compelling.

Although more recent randomized, double blind, placebo-controlled trials with Eleuthero are not abundant, there is evidence that supports those earlier findings. For example, it was shown that Eleuthero reduces the cardiovascular responses to stress of healthy individuals subjected to a stressful cognitive task.

The anti-stress effects of Eleutherococcus senticosus have also been extensively studied and demonstrated in animal research, where Eleuthero has shown positive effects in protecting from the effects of both acute and chronic stress. Eleuthero-treated animals were shown to be less prone to stress responses in behavioral tests. Eleuthero administered daily to stressed rats normalized the stress-induced changes in the function and in the weights of the adrenal and thyroid glands (which are usually shrunken by stress), and had protective effects against stress-induced gastric ulcer. Animals receiving Eleuthero also showed anti-fatigue effects, both physical and mental, and improved learning and memory abilities.

The anti-stress effects of Eleuthero may be linked to the modulation of stress-induced corticosteroid signaling. It has been shown that Eleutherococcus senticosus extract contains compounds that may bind to steroid receptors, particularly glucocorticoid receptors, which are involved in the stress response. Eleuthero may thereby prevent the activation of glucocorticoid receptors by cortisol, which may underlie its anti-stress effects in humans. Accordingly, Eleuthero, through the action of eleutheroside E, was shown to reduce the stress-induced increase in corticosterone levels (the main glucocorticoid in rats).

Another possible mechanism of action is the modulation of the brain levels of biogenic amines. Eleuthero was shown to increase the concentration of noradrenaline and dopamine in the rat brain. Administration for 2 weeks preferentially acted on the frontal cortex and anterior hypothalamus to enhance noradrenaline levels and its turnover, and the long-term administration stimulated dopamine and its turnover in the striatum and anterior hypothalamus. This indicated that Eleuthero regulates noradrenaline and dopamine levels in brain regions involved in the stress response. This is accordance with a study assessing neuronal activation in the rat brain in response to Eleuthero  administration, which showed a neuroanatomical pattern of activation of areas that regulate stress response.

Eleuthero was shown to increase serotonin synthesis and the expression of tryptophan hydroxylase (the rate-limiting enzyme in serotonin synthesis) in the dorsal raphe of rats, which may underlie its anti-fatigue effects. Furthermore, animal experiments have shown that administration of Eleuthero extracts can cause EEG alterations that indicate a stimulatory effect on the central nervous system.

Oxidative Stress:

Eleuthero extract is an antioxidant: it reduces free radicals and supports cellular health. Several compounds in eleuthero extract bind to and neutralize free radicals, preventing oxidative stress and cellular damage.

Anxiety:

Eleuthero is an adaptogen, and it may have been the first herb to receive the title of an adaptogen. Your body will likely be able to mediate your natural stress responses with Eleuthero. When you supplement with Eleuthero you will be supporting adrenal gland function. Your adrenal gland is responsible for cortisol levels and other hormones released when you experience anxiety. There are numerous studies on Eleuthero supplementation that demonstrate lowering the negative response to stress and anxiety or faster recovery from it.

Depression:

The next possible benefit of Siberian Eleuthero is if the herb can help fight depression naturally, too? Siberian ginseng has also shown anti-depressive activity.

This includes this study, where depressed test subjects appeared to benefit from an herbal extract of the plant. It seemed to work mainly by way of positively influencing the brain’s neurotransmitters. However, be wary of the side effects of Siberian ginseng. Though mild in nature some people may experience side effects such as drowsiness, changes in heart rhythm, sadness, anxiety, headache, insomnia, muscle spasms and more.

Enhances Mood:

The root of Eleuthero assists in balancing substances that determine our mood in the brain. These hormones include serotonin, norepinephrine, dopamine, and epinephrine.

Neuroprotective:

Speaking of neurotransmitters (and everything neuro-related). Research suggests Siberian eleuthero could be an overall protector of the nervous system or, more specifically, a neuroprotector. Many studies, including this one, showed neuroprotective abilities in the herb. This means that Siberian Eleuthero may reduce the risk of neurological disorders like Alzheimer’s, Parkinson’s, dementia, and many others.

Benefit for Nervous System:

Different studies have confirmed the effect of Eleutherosides in preventing and repairing nerve damage. It has been used for decades as a management and preventative medication for progressive neurological conditions like Alzheimer’s disease. A study involving rats with nerve damage confirmed the effect of Eleuthero in improving nerve regeneration and synapse reformation. One study found that eleuthero improved nerve regeneration and synapse reformation in rats with nerve damage.

Mental Health:

What’s also remarkable about Siberian Eleuthero? It appears to boost energy overall, not just strictly in a physical sense. It also appears to enhance mental performance. This includes cognitive function, learning, focus, and even memory. Combining its abilities to lift energy and boost mental faculties, people who take it report what noticeably feels like heightened mental energy.

Bipolar Disorder:

Eleuthero has been shown to help in autonomic nervous activity and might contribute to the anti-stress response. At first, as an adaptogen, it acts in a way that can enable us to adapt to different stressors easier. Second, this plant has been used in treating anxiety, even though there is not enough research, people say they had more energy and experienced a calming sensation.

Mental stress causes physiological changes as autonomic nervous activity changes BDNF expression level. Eleuthero increased hippocampal BDNF signaling. Also shown to regulate autonomic function, eleuthero may contribute to anti-fatigue and anti-stress response. Improving the recovery time of NK reduction activity and inhibition of corticosterone elevation induced by swimming. Combination of Lithium and Eleuthero has shown a potential in improving symptoms of bipolar disorder.

For those looking to boost their brainpower and get a temporary boost in intelligence, Eleutherococcus benefits are believed to be a strong contender. It has been shown to increase blood flow to the brain and small capillaries, helping with cognition, improving memory, and keeping your wits slightly sharper than normal. While the cognitive effects can vary, there is a significant improvement in the academic performance of test-takers in research settings, making it useful for students of any age. Eleuthero is considered one of the most powerful “brain herbs”, which are plant compounds that can improve mental clarity, support memory, and protect against age-related cognitive decline. More research is needed to understand the exact mechanisms of Eleuthero for supporting brain function.

Sharpens Memory:

When it comes to memory, it al goes back to how efficiently can we recall the information we are looking for. There are different types of memory, such as spatial, short-term or long term-memory. There are active ingredients in Eleuthero which are able to penetrate the brain, and those can act to enhance memory function. The beneficial effects of Eleuthero are seen as improved mental performance, increased attention, and mental endurance in situations of decreased performance caused by fatigue. Interestingly, Eleuthero root extract was shown to improve short-term memory in healthy humans, but it was also shown that the effect depended on the time of day and on the psychophysiological characteristics of the volunteers.

High levels of stress damage the brain’s ability to learn, form new memories, and retrieve existing memories. The stress-reducing effects of Eleuthero may help restore memory deficits when these deficits are caused by stress. Finally, oxidative stress decreases both short- and long-term memory. Eleuthero’s antioxidant actions might help improve memory in this way, as well.

Alzheimer’s Diseases:

Eleuthero aids in combating Alzheimer’s disease by promoting transmission of nerve impulses. Hence, it nips in the bud, the onset of this debilitating disease. Eleuthero was found to enhance the neuronal communication concerned with memory and learning in animal studies and this property could be of great benefit in helping patients living with Alzheimer's Disease. Eleuthero also has a significant stress-reducing ability that helps restore memory deficits as a result of excess stress.

Parkinson's Diseases:

Parkinson’s disease causes damage and degeneration in the basal ganglia region of the brain. This degeneration leads to the movement problems typical of people with Parkinson’s disease. Eleuthero may help prevent these symptoms.

Your liver is a key organ for your immune system. Consequently, Eleuthero boosts your immune system by promoting your livers natural detoxification process. Likewise, Eleuthero extract can help your liver process harmful toxins including alcohol, sodium barbital, and tetanus toxin. Siberian ginseng not only detoxifies the liver, removing harmful toxins from radiation exposure especially after chemotherapy treatment, it helps in lessening the side effects of chemotherapy. It is also useful in bone marrow suppression after exposure to radiation procedure or chemo treatment. Siberian ginseng can also work wonders for your liver.

For decades, Eleuthero has proved to be an active agent in improving blood sugar levels, blood lipid levels and insulin usage in diabetics. When tested out in type 2 diabetes mice, it was observed that it significantly reduced insulin resistance and thus reduced blood glucose levels. In a laboratory study to confirm the effect of the eleutheroside components; eleutherans A, B, C, D, E, F and G on blood sugar, it was proved that these compounds were able to normalize blood sugar levels making Eleuthero very useful for improving diabetes.

There is also evidence that the regular use of Eleuthero can help to regulate blood sugar levels, reducing the flexibility of your glucose and insulin levels to prevent diabetic shock from occurring. This is good news for diabetics, as those blood sugar fluctuations can be deadly, and any type of insulin regulator is always appreciated.

Some evidence shows that Eleuthero supplements may help prevent diabetes by supporting healthy blood sugar and insulin control. Eleuthero has produced positive results for the benefits in this section only in limited, low-quality clinical studies. There is insufficient evidence to support the use of eleuthero for any of the below-listed uses. Furthermore, the FDA has not approved Eleuthero for any medical purpose or health claim, and there is no guarantee of the quality of any given supplement. Remember to speak with a doctor before taking eleuthero supplements. Eleuthero should never be used as a replacement for approved medical therapies.

Blood Sugar:

Eleuthero, which is still sometimes called by its original botanical name Acanthopanax senticosus, may improve symptoms of diabetes. Eleutherosides have been shown to reduce insulin resistance and are being considered for the management of type 2 diabetes. There is also a potential for anti-diabetic effects of Acankoreagenin from Eleuthero leaves are found. This study demonstrates that Acankoreagenin might offer therapeutic benefits for treating diabetes.

Most certainly, especially when it comes to metabolism, Siberian Eleuthero helps the body metabolize fats much easier, including cholesterol. Though more studies are needed to clarify exactly how this works, and how well, this suggests that, in addition to boosting athletic performance, Eleuthero may be an excellent choice herb for naturally supporting a healthy weight and metabolism.

Prevents Impotence:

Eleuthero is useful in facilitating testosterone production in men hence increasing sex drive and combating impotence. Panax ginseng is particularly useful in raising sperm count and can therefore be used after Eleuthero.

Menstrual Discomfort:

Siberian Ginseng may positively affect hormone levels and tone the large uterine muscle. These properties make it potentially valuable for easing certain menstrual difficulties. By positively influencing hormone balance in women reproductive cycle, eleuthero assists in relieving of menstrual disorders.

Menopause:

Eleutherosides are a group of chemical compounds isolated from the eleuthero plant. These bioactive ingredients are largely credited for this herb’s anti-fatigue and stress-relieving effects. Preliminary studies suggest that eleutherosides may also bind to estrogen receptor sites, potentially reducing menopausal symptoms such as hot flashes, decreased sex drive, and fatigue. Extracts of Eleuthero and eleutherosides are known to bind to estrogen receptor sites. Eleuthero may, therefore, lessen the effects of estrogen withdrawal in women who are experiencing menopause. For this reason, women with estrogen-driven cancer may need to consult their doctor before consuming Eleuthero.

This adaptable herb is beneficial to both men and women in the realm of sexual health. In women it supports healthy menstruation and uterine tone. It is often prescribed by herbalists to combat infertility related depression and fatigue. Offering a fertility boost to men too, a recent study found it significantly raises free testosterone levels resulting in a better sperm count and motility.

Increases Male and Female Fertility:

By supporting healthy uterine function, Siberian Ginseng may be useful in preventing female infertility. Males may experience an increased sperm count. Animal studies show that the herb can even boost testosterone levels and thus help reverse certain cases of male impotence.

Increases Libido:

This herb can be beneficial both for men and women in terms of sexual health. On the one hand, it will support a healthy menstruation and uterine tone for women. Moreover, people use it quite often in order to fight against infertility related to depression and fatigue. On the other hand, a recent study found that it can increase the free testosterone levels considerably, resulting in more quantity and motility of sperm in men.

In addition, Siberian Ginseng acts on the endocrine system and the production of different hormones. It stimulates the activity of the sex glands, so we could say that it has aphrodisiac effects.

In addition to Eleuthero ability boost your immune system through antioxidant properties and liver functions, Eleutherosides, the main compound found in eleuthero root, have shown an ability to improve immune function. Your immune system plays a vital role in stopping pathogens before they make you sick. Adaptogens in general have a positive effect on immune health because they support the normal, healthy functioning of your body. This research into the powerful properties of eleutherosides confirms a traditional use of eleuthero for maintaining overall health. Eleuthero may also weaken viruses. You may find it interesting that Eleuthero demonstrated that it could inhibit virus cell replication in cell cultures. Following a review of studies where a standardized extract of Eleuthero was used, it was confirmed that this herb is effective in treating herpes simplex 2. More importantly, many people have found Eleuthero to reduce symptoms and recovery time for the common cold and other RNA viruses, including influenza A virus, respiratory syncytial virus, and human rhinovirus. The herb helps fight against these viruses as it prevents their replication. The same mechanism in Eleuthero that helps your body fight RNA viruses may also contribute to its anti-cancer and anti-tumor properties.

Herpes Simplex Viruses:

Siberian Ginseng is a natural remedy that is very useful in the treatment of herpes caused by the herpes simplex virus type 2. This virus is the main cause of the very painful genital herpes. In a study, it was found that over a course of three months there was major improvement in cases of genital herpes where Siberian Ginseng was used.

SARS-CoV-2 (COVID-19 - Corona Virus):

A word on the effects of eleuthero extract for COVID-19. To date, no supplement, diet, or medicinal herb has been shown to prevent or treat COVID-19. Maintaining a healthy lifestyle, practicing proper hygiene, and following guidelines are the most effective ways to keep your immune system healthy and reduce your chance of infection.

If you suffer from colds, coughs, bronchitis, or other respiratory conditions, eleuthero tea may be a good solution. It has certain anti-inflammatory properties that help eliminate the symptoms of those conditions, while also helping to eliminate the underlying diseases that cause them. Eleutherococcus benefits also act as an expectorant, helping to remove phlegm and mucus where pathogens and bacteria can settle and thrive.

Respiratory Tract Infections:

As an immune stimulant, eleuthero may shorten the length and severity of lung infections, such as influenza and pneumonia. The leaves of Eleuthero can either be prepared as a tea or eaten raw. However, most studies that have looked into the health benefits of this amazing herb have only focused on the root, meaning it is possible not to have as much effect of Eleuthero with the leaves as with its root.

Cold and Flu:

Eleuthero root benefits also include its proven ability to help fight viruses that cause the common cold as well as the flu. It’s often used as a natural cold and flu remedy. Because it can help boost immunity, this Siberian herb may be good for fighting (and reducing the risk of) colds and flu. After all, ramping up immunity naturally is one of the best ways to keep these viral illnesses at bay. But this close relative of ginseng may have another card up its sleeve. Not only might it help directly fight colds, flu, and other viruses, studies also show it may help suppress coughs, with the help of (and in combination with) other healing herbs.

Studies have shown that Eleuthero is helpful in lowering the severity of cold at its onset when used with a combination of other herbs such as andrographis. It offers relief within five days after use. It have shown that the duration and intensity of common illnesses like cold and flu may be mitigated through the timely use of Siberian Ginseng.

Traditional practitioners use Eleuthero extract for viral infections, including the common cold and flu. In limited clinical trials, an extract of Siberian ginseng appeared to reduce the symptoms of the common cold if it was taken within 72 hours of symptoms appearing. Researchers infected human lung cells with influenza virus, which causes the flu, and treated half with eleutheroside B1; these cells produced far less of the virus.

Although research is limited, proponents claim that Siberian Ginseng also supports the immune system.

Eleutherosides have been shown to improve the lymphatic function of the lymph node network, meaning they may reduce edema. Edema is swelling caused by a build up of fluid. Within four hours of taking Eleuthero, healthy women had reduced swelling in their lower legs. Eleutheroside E appears to activate a receptor called Tie2, which stabilizes lymph vessels and improves the function of the lymphatic system.

Like many healing herbs and mushrooms before it, Siberian eleuthero is a great wellness protector in one very simple way: it is an antioxidant. This means that the herb can scavenge free radicals and protect the body. It also means that it could help one age more gracefully, too, if taken over a long time. Eleuthero’s antioxidant activity was confirmed in this study, indicating that on a very fundamental nutrition level, the Asian herb may help shield tissues, organs, and systems from illness, degeneration, and the long-term effects of aging.

It has been suggested that the adaptogenic and protective effects of Eleutherococcus senticosus may be largely due to the many phenolic compounds with antioxidant action it contains. In line with this possibility, there have been many studies that highlighted that antioxidant effects of Eleuthero. Eleuthero supplementation administered to postmenopausal women for 6 months was shown to decrease the levels of markers of oxidative stress.

Antioxidant effects have also been shown in animal studies. Eleuthero has been shown to be a strong antioxidant, able to reduce the nitric oxide and lipid peroxidation levels, to increase the activities of antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase, and to increase the content of reduced glutathione. It was also shown to be an effective free radical scavenger.

Since oxidative stress is a major cause of tissue and organ dysfunction, it would be expected that the antioxidant effects of Eleuthero could contribute to the protection of tissues and organs. Accordingly, Eleuthero was shown to protect cardiac muscle cells against oxidative-stress injury by enhancing antioxidant defenses. Eleuthero also protected against kidney dysfunction, liver injury and dysfunction, and brain damage caused by cerebral ischemia.

The neuroprotective effects of Eleuthero seem to be due not only to an antioxidant effect, but also to an inti-inflammatory activity, since Eleuthero was shown to inhibiting inflammation and microglial activation in brain ischaemia. Furthermore, Eleuthero also protected neurons against neuritic atrophy and cell death caused by neurotoxic agents (amyloid beta).

Extracts of Eleutherococcus senticosus (containing 2.1% eleutherosides B+E) significantly increased the resistance of the nematode Caenorhabditis elegans to heat stress and oxidative stress, and favored the synthesis of proteins involved in stress resistance (such as the chaperone HSP-16) and longevity. Importantly, Eleuthero increased the mean lifespan of C. elegans between 10 and 20% and delayed the moment when the first individuals in a population died, indicating an anti-aging effect. A noteworthy finding was the fact that this effect depended on the dose, with higher doses causing less beneficial effect; at highest concentration tested, a lifespan shortening effect was actually observed, indicating that, at excessive doses, Eleuthero may lose its beneficial effects.

Free Radicals:

Part of the immune boosting properties of Eleuthero benefits is its antioxidant properties. Understandably antioxidants fight free radicals and preserve cellular health. Additionally, your body has increased free radicals during times of oxidative stress, which in turn can increase the likely hood of cell damage. Most importantly several compounds in Eleuthero can bind to and neutralize free radicals, reducing your bodies cellular damage.

Eleuthero is an ancient part of traditional medicine in eastern Asia, but its involvement in modern science is fairly new; Soviet scientists conducted some promising studies before 1990, but many of these have yet to be repeated. In countries like China, Japan, Korea, and Russia, people commonly used Siberian Ginseng for its anti-fatigue, anti-inflammation, anti-stress, anti-ulcer and cardio-boosting qualities. Now recent research is pointing towards the ability of this impressive plant to fight cancer.

By slowing cancer progression and boosting the body’s immune system, Eleuthero has shown a promising effect in improving cancer outcomes. In a study, it was found to significantly reduce the growth of lung and liver cancers. Eleuthero also helps protect from the mutation of cancerous cell aside helping to fight already formed cancer cells. Eleutheroside E appears to act against the effects of estrogens in cancer cells. In a study using human cancer cells, eleuthero extract and eleutheroside E significantly decreased estrogen receptors. Although this herb is also suggested as an option to reduce estrogen dominance, there’s no solid research to back up its anti-estrogen effects in women, nor are there enough data to support the vastly over-hyped theory of estrogen dominance.

Eleuthero extract seems to increase immune function in healthy people and in people with cancer; some researchers believe that it may reduce long-term infection risks and help the body fight off a malignant tumor, but this hasn’t been proven in clinical trials. When researchers exposed healthy bacteria to cancer-causing poisons, eleuthero extract dropped their mutation rate by more than half. Eleuthero extract may also protect cells from mutations due to radiation exposure, but this effect is small. More directly, eleuthero has been studied for potential against human stomach, lung, and throat cancer cells in a lab setting. Furthermore, eleuthero blocks estrogen receptors in cell studies; future research will investigate whether it could be useful in estrogenic cancer types.

Researchers have also recently used Eleuthero to synthesize a silver nanoparticle that increases oxidative stress and selectively kills cancer cells. This natural-source nanoparticle was more effective in a lab setting than either a commercial silver nanoparticle or Cisplatin, a common chemotherapy drug. All the same, studies like this one show that this botanical can encourage cancer cells to stop spreading, and in some cases, to even destroy themselves, thus slowing cancer development and also supporting cancer therapy. It’s far from being a cancer remedy, that’s for sure. But in the future, Siberian Eleuthero could be a goldmine for cancer research.

Of the existing research pool, many studies focus on single isolated compounds or on herbal combinations like Kan Jang. Eleuthero extracts can also be produced from bark, root, leaves, or berries, and the differences between these extracts have yet to be fully explored.

Some of the studies mentioned above suffer from design flaws or small sample sizes. Much of the available research comes from cell studies (especially cancer cell studies), with fewer live animal studies and even fewer human trials. Finally, even the human studies may be flawed: the dosage of Siberian ginseng varied wildly, and in some “no effect” studies, participants took tiny doses of Eleuthero.

None of this research should be taken as grounds to use Eleuthero in an attempt to fight cancer. If you believe that Siberian ginseng could be part of a complementary health strategy, talk to your doctor.

Cancerous Tumours:

You may want to consider taking Eleuthero for its promise in improving cancer outcomes.  You may be surprised that Eleuthero can slow the progression of cancer and boosting the immune system.  Not only could Eleuthero help fight cancerous cells that have already formed but may also help protect against cell mutations such as tumors. Additionally, if you are in a field that may expose you to radiation exposure or you spend a majority of your time outside in the Sun’s radiation you may consider taking Eleuthero.  Because Eleuthero has been shown to protect against mutations due to radiation exposure.  Equally important that Eleuthero has been studied to fight breast cancer and patients found a boost in their immune system when fighting breast cancer.

If it’s good for immunity and good for inflammation, then it’s very likely that Siberian Eleuthero is an excellent natural remedy for digestive health, too. The research is certainly there to back up eleuthero’s gut-boosting prowess.

Combined with probiotics, using Siberian Eleuthero could pack a powerful punch for gut health in the long run, and needs further exploration in research.

Siberian Eleuthero is shown to have anti-inflammatory effects, too. This can make the herb an excellent fighter against conditions involving chronic inflammation, possibly including autoimmune disorders. If you suffer from any kind of inflammatory disease, such as osteoarthritis or gout, Siberian Ginseng can be quite beneficial.

Some pain-relieving drugs like naproxen sodium work by inhibiting the inflammatory pathway activating enzyme, COX-2. Eleuthero has also been found to be associated with reduced expression of COX-2, thus making it a promising agent for preventing inflammation. It also reduces the excess mast cell activity associated with allergic inflammation. Cyclooxygenase 2, or COX-2, is an enzyme that increases inflammation and pain. Commonly used NSAIDs mainly work by blocking it. The extract of eleuthero fruit activates an enzyme called heme oxygenase 1 (HO-1), which blocks COX-2 and thereby reduces inflammation.

Familial Mediterranean Fever (FMF):

Familial Mediterranean Fever is a genetic condition that causes episodes of inflammation marked by fever, pain, and redness of the skin. In combination with other herbs, eleuthero may reduce the symptoms of FMF in children. Eleuthero shows promise for improving memory and reducing inflammation, but further research is needed.

Not too many herbs can claim to be good for bone health. But in the case of eleuthero, research suggests this botanical may be an excellent supplement to pop on the daily for keeping one’s bone health in tip-top shape.

Osteoarthritis:

Studies have linked eleuthero use with successful management of osteoarthritis. This herb relieves pain and alleviates physical symptoms of osteoarthritis.

Increases Bone Density:

Bone loss is tightly related to the estrogen hormone levels. It turns out that Eleuthero may have a potential effect here, in preventing bone loss without influencing estrogen hormones. This can be a more natural alternative for postmenopausal osteoporosis.

Osteoporosis:

Scientific studies show that the herb helps slow bone loss. Such results heavily imply Siberian Eleuthero may be a great holistic supplement for slowing (or reducing the risk of) bone illnesses like osteoporosis, though more studies are needed. Preliminary data look encouraging, but the effectiveness of Eleuthero in people with osteoporosis or hangovers is unknown.

Cadmium Poisoning:

Cadmium is a toxic heavy metal that suppresses the immune system. During exposure, cadmium builds up in the spleen and decreases the number of white blood cells in this organ. The more cadmium is built up, the fewer white blood cells are found in the spleen, and the weaker the immune system becomes.

Heals Wound and Prevent Ulcers:

By boosting the immune system, Eleuthero may help speed up healing process. The compound components of Eleuthero have also shown some properties that could help prevent ulcer formation, including diabetic foot ulcers.

Each year, there are more and more people who are allergic to either natural or synthetic substances. Moreover, many people suffer hay fever each spring. This can have serious consequences, from discomfort to not being able to go to work or having a social life. Eleuthero may also reduce allergy symptoms. Mast cells, a type of white blood cell, are responsible for most allergic reactions; eleuthero reduces the activity of mast cells in rats.

The standard dose for eleutherococcus senticosus is 300-1200 mg. Although traditionally, the most advised range is 2-4 g. The most common formats are root and stem extracts, but it can also be available as leaf extracts. For periods of fatigue or stress. You can take siberian ginseng for 3 months, followed by 3 or 4 weeks of rest. Do not take Siberian Ginseng without consulting your doctor previously.

Mosquito Bites:

Essential oil from Eleuthero leaves stops mosquitoes from biting. The complete oil is about three-quarters as effective as DEET at preventing mosquito bites; an isolated compound called α-bisabolol is as effective as DEET. Only one study has ever been performed on the potential insect repellent property of Eleuthero, further research is required.

• Alzheimer’s Disease: 100-200 mg 3 times a day
• Arthritis: 100-200 mg twice a day for generalized fatigue
• Back Pain: 200 mg twice a day for generalized fatigue
• Chronic Fatigue Syndrome: 400 mg every morning
• Colds: 300 mg twice a day for 7-10 days
• Fatigue: 100-200 mg twice a day
• Flu: 300 mg twice a day for 7-10 days.
• Impotence: 100-300 mg twice a day
• Male Infertility: 200 mg twice a day
• Menopause: 200-400 mg standardized extract each morning
• Multiple Sclerosis: 200 mg twice a day
• Perimenopause: 200-400 mg standardized extract each morning
• PMS: 100-200 mg twice a day for generalized fatigue
• Stress: 100-200 mg 2 or 3 times a day
• Stroke: 200 mg twice a day

Traditional Uses of Eleuthero - Siberian Ginseng:

• Siberian Ginseng is a powerful tonic herb with an impressive range of health benefits. Unlike many herbs with a medicinal use, it is more useful for maintaining good health rather than treating ill health.
• Research has shown that it stimulates resistance to stress and so it is now widely used as a tonic in times of stress and pressure.
• It is considered as an herbal remedy that increases energy, boosts the immune system, and helps alleviate general fatigue.
• This plant is a very commonly used folk treatment in China and Russia where it is used as a Ginseng substitute.
• It is a pungent bitter-sweet warming herb that is said to be stronger in its action than Ginseng.
• Regular use is said to restore vigour, improve the memory and increase longevity.
• The root and the root bark are adaptogen, anti-inflammatory, hypoglycaemic, tonic and vasodilator.
• It encourages resistance to stress and so it is now widely used as a tonic in times of stress and pressure.
• Regular use is said to restore vigor, improve the memory and increase longevity.
• It is taken internally during convalescence and in the treatment of menopausal problems, geriatric debility, physical and mental stress etc.
• It works by strengthening the bodies natural immune system.
• It is used for headaches, infection, gastrointestinal issues and sterility.
• It has also been used to combat radiation sickness and exposure to toxic chemicals.
• This herb is not prescribed for children, and should not be used for more than 3 weeks at one time.
• It was traditionally used to prevent colds and flu and to increase energy, longevity, and vitality.
• It has also been used to combat radiation sickness and exposure to toxic chemicals.
• Caffeine should not be taken when using this herb.
• The roots are harvested in the autumn and dried for later use.
• The German Commission E Monographs, a therapeutic guide to herbal medicine, approve Eleutherococcus senticosus for tendency to infection, lack of stamina.

Culinary Uses of Eleuthero - Siberian Ginseng:

• Young leaves and buds can be cooked.
• The dried leaves are used as a tea substitute.

• Altitude Sickness: Put 10 drops of tincture in quarter glass of water. Drink it twice a day. / Take Siberian Ginseng in capsules form 300 mg per day.
• Aphrodisiac: Prepare a decoction of Siberian Ginseng roots in one cup of water. Strain and drink it.
• Bladder Cancer: Prepare a decoction of Ginseng Siberian. Drink twice a day. / Eat Siberian Ginseng capsules 300 mg per day.
• Bone Infection: Add 2 tsp of dried Siberian Ginseng in a cup of hot water. Steep for 15 minutes. Strain it and drink twice daily.
• Colon Cancer: Prepare a cup of Ginseng tea by boiling Ginseng in water for 5 minutes. Drink it twice a day to treat the symptoms related with colon cancer.
• High Creatinine: Take 1 tsp of dried Siberian Ginseng. Prepare a decoction and drink once a day. / Take once 300 mg capsules every day.
• Hyperthyroidism: Add 1 to 2 tsp of dried Siberian Ginseng in a cup of hot water. Let it steep for 10-12 minutes. Strain well and drink it lukewarm. Have it two times a day.