Health Benefits and Uses of Marjoram

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Marjoram (Origanum majorana)

Marjoram scientifically known as Origanum majorana, also called Wild Oregano or Sweet Marjoram, Pot Marjoram, Knotted Marjoram or Garden Marjoram is an herb that is a member of the mint (Lamiaceae) family, also known as the mint family, which includes 200 genera and 3500 species spread all over the world.. Genus name probably comes from the Greek words "oros" meaning "mountain" and "gamos" meaning "beauty" in reference to the physical appearance of this plant which is sometimes native of mountain areas where it is appropriately referred to as "beauty of the mountain". The genus Origanum comprises over 44 species and includes several types of Oregano as well as Marjoram (Origanum majorana) and Dittany of Crete (Origanum dictamnus). Although closely associated with Oregano, Marjoram and Oregano are two different herbs. Both are commonly used in Greek and Mediterranean recipes, but Marjoram has a lighter, sweeter, more floral flavor than Oregano. The herb is native to Cyprus and the neighboring part of South Turkey. It is cultivated in several countries in Europe, Africa, America, and Asia. It is found in footpaths, fields, dry slopes, rocky places, and farmhouses. It generally prefers warm, dry and well-drained loamy soils, although it has been found as far north as England and is now naturalized in the United States. Marjoram is a somewhat cold-sensitive bushy, perennial herb or undershrub that grows as annual. It is cold sensitive, frost tender aromatic herb that grows up-to 60-75 cm tall. The leaves of this plant are simple, smooth, ovate, and grey in color. The leaves are 0.5-1.5 cm long and 0.2-0.8 cm wide, and it has a smooth texture with lots of hairs. The flowers of Marjoram are small, beautiful, white or pale pink flowers. The flowers are 0.3 cm long and have 1.3 cm long heads. It contains oval-shaped seeds and dark brown seeds. It contains sub-cylindrical and wrinkled taproots that are 0.2-0.6 mm in diameter. The herb has sub–cylindrical, longitudinally wrinkled tap roots with transverse fissures, 0.2-0.6 mm in diameter. The outer surface of root is dark brown while light brown internally with several long rootlets and root scars are also present. It has descending multi-branched reddish square stems that spill over to create a mound. The stems are straight having weak, hairy, round and green with red speckles.

Marjoram is addressed as the herb of "eternal love" and "joy of the mountain". As the most loved herb by Aphrodite, the Goddess of love and beauty, the leaves of Marjoram were sanctified for surmounting marital bliss and everlasting love. The spicy, rich, sweet, soothing and tantalizing aroma of this oil will leave you relaxed, energized and absolutely rejuvenated. The oldest historical uses of Marjoram take us to the ancient Greek mythology, where it was used for treating muscular tension, poisonous stings and bites, discarding fluid retention and as a symbol of love and affection. Marjoram has been an interesting part of wedding rituals, where the Newly-wed couples wear Marjoram wreaths as a sign of beginning their magical love life. For this reason, it was common for Greek brides, and later, Roman brides as well - to wear crowns made from marjoram on their wedding days. It is an ancient belief that if a Marjoram plant grows on a grave, and then the deceased person has attained perpetual happiness in the world after. The aromatic leaves and flowers of this plant were strewn in homes for its antimicrobial, disinfectant and deodorant properties. Folklore beliefs also include the use of Marjoram as a rescuer from bad luck and curses. It was used as a medicinal herb during the Middle Ages in the locations where it grows naturally, and it began to be used as a seasoning in the 16th century, mainly in Europe. It is still widely popular, both as a culinary herb and as an herbal remedy.

Marjoram is a popular herb (fresh or dried) for seasoning soups, sauces, salads, stuffing, stews, roasts, vegetables and meats. It has a mild flavour and is used as a key ingredient in French, Italian and Greek cuisine. Fresh leaves do not freeze as well as Oregano leaves. It’s particularly powerful when dried but can also be used fresh. Dried leaves are sometimes added to Pot-Pourris. The essential oil is used in cooking purposes to spice up the food. Also used in hundreds of food recipes, soups, and dressing. The essential oil obtained from Marjoram confers several culinary and medicinal benefits and it is also used in manufacturing soaps. Indigenous to Southern Europe, Marjoram is used as a flavoring ingredient and as a condiment. It is used in various food varieties including salamis, stews, seasonings, marinades, dressings, salads, roasted meat, sausages and goes well with green and leafy vegetables. Traditional home remedies with Marjoram include poultices for healing boils, rashes, sprains and abrasions.

Health Benefits of Marjoram

Apart from being a tasty culinary herb, Marjoram both in its food and oil form has a number of excellent benefits for your health. It consists of numerous healthy minerals and vitamins and has a number of excellent medicinal properties. Among its many uses, Marjoram can protect the heart health, the digestion system, and prevents diabetes. The leaves and seeds of this plant contain different medicinal values to treat various diseases. The oil prepared from Marjoram also contains many effective health benefits. What’s more, Marjoram has been shown to have several anti-inflammatory and antimicrobial properties. It has been used medicinally to help treat a variety of ailments, including digestive issues, infections, and painful menstruation. Marjoram teas and infusions are extremely famous for their power in relieving headache, sinusitis, flatulence, hay fever and menstrual discomforts. The herb has been used in the Traditional Austrian Medicine for treatment of disorders of the gastrointestinal tract and infections. Known to the world of Ayurveda as Maru, Marwa, Sinshi and Sathra, Marjoram has been recommended for treating muscular tension, cardiovascular problems, premenstrual problems, polycystic ovarian syndrome, sinus congestion, insomnia, Alzheimer’s disorder, asthma, joint pain, flatulence, rheumatism, toothache, loss of libido and certain other health conditions.

Marjorm contains lots of vitamin, minerals and other components. Some of the vitamins Marjoram has vitamin A, vitamin C, vitamin E, vitamin K, folate, thiamin, niacin, pyridoxine, pantothenic acid and riboflavin. Marjoram also contains dietary fiber, sodium and potassium, which have lots of health advantages. Apart from this Marjoram also contains minerals such as calcium, magnesium, iron, protein, zinc, copper and manganese. The best part of the Marjoram is, it contains zero cholesterol. Marjoram is also contain some of the phyto-nutrient, such as beta-carotene, beta- cryptoxanthin and lutein-zeaxanthin.

Ancient Greeks believed that Marjoram had been given its scent by the Greek Goddess Aphrodite, who wanted to symbolize happiness with its sweetness. Increased longevity has also been attributed to the this aromatic herb, and it was grown on gravesites with the purpose of bringing comfort to the souls of the dead ones. It was also believed that applying Marjoram oil at bedtime would bring dreams about the future.

A 2018 comprehensive review "Carvacrol and human health" published in Phytother Res. by Mehdi Sharifi-Rad, Elena Maria Varoni, Marcello Iriti, Miquel Martorell, William N Setzer, María Del Mar Contreras, Bahare Salehi, Azam Soltani-Nejad, Sadegh Rajabi, Mercedeh Tajbakhsh, Javad Sharifi-Rad, carvacrol is a phenolic monoterpenoid found in essential oils of Marjoram (Origanum majorana), Oregano (Origanum vulgare), Thyme (Thymus vulgaris), Pepperwort (Lepidium flavum), Wild Bergamot (Citrus aurantium bergamia), and other plants. Carvacrol possesses a wide range of bioactivities putatively useful for clinical applications such antimicrobial, antioxidant, and anticancer activities. Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety. The present review illustrates the state-of-the-art studies on the antimicrobial, antioxidant, and anticancer properties of carvacrol. It is particularly effective against food-borne pathogens, including Escherichia coli, Salmonella, and Bacillus cereus. Carvacrol has high antioxidant activity and has been successfully used, mainly associated with thymol, as dietary phytoadditive to improve animal antioxidant status. The anticancer properties of carvacrol have been reported in preclinical models of breast, liver, and lung carcinomas, acting on proapoptotic processes. Besides the interesting properties of carvacrol and the toxicological profile becoming definite, to date, human trials on carvacrol are still lacking, and this largely impedes any conclusions of clinical relevance.

Digestive Disorders:

Marjoram has historically been used to prevent digestive issues like stomach ulcers and certain foodborne illnesses. Marjoram is one of those wonderful herbs that can help improve your general digestion and also many specific problems with your digestive system. If you are suffering from gas, Marjoram essential oil is a good remedy for you. It can help expel any gas from your intestines, and even helps with the symptoms of gas such as abdominal cramps, chest pain, vomiting, headaches, pain the limbs, and so on. Marjoram also helps prevent the various digestive problems including flatulence, colic, constipation, indigestion and stomach infections.

Moreover, Marjoram essential oil can help facilitate digestion. It stimulates the production of bile and gastric juices in the digestive tract, which helps break down your food faster and move it along the entire system, that keep the PH levels in the stomach at a normal and healthy level, preventing any prolonged acidity, and therefore ulcers as well. It even stimulates the salivary glands and as a results, works on the very first steps of digestion in the mouth itself.

Furthermore, Marjoram essential oil stimulates peristalsis in the intestines. This refers to the contraction and release of the muscles, which allow the food to move down towards the colon. This oil, therefore, allows you to have better and regular bowel movements and is extremely beneficial for those who are suffering from constipation. It works as an effective laxative.

Finally, Marjoram essential oil is also a good stomacic. This means that it boosts the health of the stomach by preventing ulcers and other digestive disorders. Ulcers occur on the lining of the stomach due to acidity that’s been occurring for a long time. This oil is, therefore, extremely good for your digestion on the whole.

The regular intake of Marjoram tea has been found to help people cope with eating disorders. When used to make tea, Marjoram can improve your digestion by increasing production of digestive enzymes that help break down food. In addition, Marjoram tea can help alleviate common digestive disorders such as flatulence, constipation, diarrhea and stomach cramps. Leaves of Marjoram act as a soothing tonic that helps improve the performance of the digestive system. It can boost your appetite and promote digestion by stimulating the production of saliva and digestive enzymes.

If you suffer from digestive problems like nausea, flatulence, stomach cramps, diarrhea or constipation, a cup or two of Marjoram tea can help alleviate your symptoms. You can also try adding the fresh or dried herb to your next meal for digestive comfort or use Marjoram essential oil in a diffuser. Marjoram infusions are perfect for soothing gastric disorders.

Indigestion (Dyspepsia):

Including Marjoram spice in you diet may help to improve your digestion. The scent of it alone can stimulate the salivary glands, which helps the primary digestion of food that takes place in your mouth. Research shows that its compounds have gastroprotective and anti-inflammatory effects. The herb’s extracts continue to help you digest your meals by stimulating the peristaltic movement of the intestines and encouraging elimination.

Gastric Acid and Pepsin Secretion:

A 2007 study "Marjoram increases basal gastric acid and pepsin secretions in rat" published by Rafsanjani F N et al., shows the Marjoram contains some components that activate chief and parietal cells and increase basal acid and pepsin secretion.

Abdominal Disorders:

A 2018 study "Antispasmodic and Myorelaxant Activity of Organic Fractions from Origanum majorana L. on Intestinal Smooth Muscle of Rodents" in European Journal of Medicinal Plants by Hanane Makrane, Mohammed Aziz, Hassane Mekhfi, Abderrahim Ziyyat, Mohamed Bnouham, Abdelkhaleq Legssyer, Bernard Gressier and Bruno Eto, evaluated the pharmacodynamic effects of Origanum majorana on isolated smooth muscles preparations of guinea pig's ileum and rat's colon. Results showed significant antispasmodic effect with a potential benefit for the treatment of colic in gastrointestinal disorders. Study confirmed the antispasmodic and myorelaxant activity of organic fractions of Origanum majorana in rat and rabbit jejunum. Results showed that adrenergic receptors, guanylate cyclase or muscarinic receptor pathways were not involved in relaxation induced by DFOM suggesting the antispasmodic effect on intestinal smooth muscle was non-competitive antaganism towards voltage-dependent calcium channels.

Gastric Mucosal Injury:

A 2009 study "Protective Effect of Origanum majorana L. Marjoram on various models of gastric mucosal injury in rats" published in Am J Chin Med. by Tawfeq Al-Howiriny, Abdulmalik Alsheikh, Saleh Alqasoumi, Mohammed Al-Yahya, Kamal ElTahir, Syed Rafatullah, evaluated the antiulcerogenic activity of the ethanol extract in hypothermic restraint stress-, indomethacin-, necrotizing agents- (80% ethanol, 25% NaCl and 0.2 M NaOH) induced ulcers and basal gastric acid secretion using pylorus ligated Shay rat-model. Marjoram at doses of 250 and 500 mg/kg of body weight, significantly decreased the incidence of ulcers, basal gastric secretion and acid output. Furthermore, the extract replenished the ethanol-induced depleted gastric wall mucus and nonprotein sulfhydryls (NP-SH) contents and significantly lowered the increase in the concentration of malondialdehyde (MDA). Ulcer preventing potential was further confirmed by histopathological assessment. An acute toxicity test showed a large margin of safety of the extract in mice. The phytochemical screening of aerial parts of Marjoram revealed the presence of volatile oil, flavonoids, tannins, sterols and/or triterpenes.

Gastric Ulcer:

It is unclear why some people are more predisposed to developing gastric ulcers than others, though it has been observed that these individuals have higher colonies of the H.Pylori bacteria in their digestive tract. Marjoram consumption has been found to significantly reduce the likelihood of ulcers developing, even if you already have a history of them. Plus, it can actually promote healing of the ulcers by reinforcing the mucosal lining of the stomach that protects it from hydrochloric acid. Marjoram essential oil may also neutralize stomach acids to prevent gastric ulcers.

A study of six herbs revealed that Marjoram fought against Clostridium perfringens, a common foodborne pathogen. In addition, a rat study noted that its extract protected against stomach ulcers. Still, human studies are needed.

A 2009 animal study "Protective Effect of Origanum majorana L. 'Marjoram' on various models of gastric mucosal injury in rats" published in The American Journal of Chinese Medicine evaluated Marjoram’s ability to prevent and treat gastric ulcers. The study found that at doses of 250 and 500 mg per kilogram of body weight, it significantly decreased the incidence of ulcers, basal gastric secretion and acid output. Furthermore, the extract was found to replenish depleted mucus of the gastric wall, which plays a key part in the healing of ulcers and lowered the increase in malondialdehyde. Study evaluated the antiulcerogenic activity of ethanol extract in hypothermic restrained-stress-, indomethacin-, necrotizing agents-induced ulcers and basal gastric acid secretion in pylorus ligated Shay rat model. Marjoram not only prevented and treated ulcers, but it was also proved to have a large margin of safety. The aerial (above ground) parts of Marjoram were also shown to contain volatile oils, flavonoids, tannins, sterols and/or triterpenes. While research remains preliminary, Marjoram use for stomach health is promising.

Stimulates Appetite:

The leaves of Marjoram act as a soothing tonic that helps improve the performance of the digestive system. It can boost your appetite and promote digestion by stimulating the production of saliva and digestive enzymes.

Matabolism:

Ayurveda states that ama or toxic remains as a result of improper digestion is the root cause for health conditions like obesity. Marjoram essential oil has carminative properties with its ability to enhance pitta dosha, which is responsible for digestive fire and metabolic functions.

Massaging the abdomen with 3 drops of Marjoram oil, 3 drops of Nutmeg oil and 1 drop of Spearmint oil with 3 ounce of Coconut oil can support in stimulating the salivary glands, augmenting the secretion of bile, digestive enzymes and other gastric juices. This is turn aids in enhancing the appetite, treating flatulence, diarrhea, nausea, abdominal spasms, constipation and also in soothing the intestinal and lining of the stomach.

Diarrhea:

A 2019 study "Origanum majorana L. extract exhibit positive cooperative effects on the main mechanisms involved in acute infectious diarrhea" published in Journal Ethnopharmacol. by Hanane Makrane, Mohammed Aziz, Hassane Mekhfi, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Ahmed Melhaoui, Mohamed Berrabah, Mohamed Bnouham, Chakib Alem, Ferdinand Kouoh Elombo, Bernard Gressier, Jehan-François Desjeux, Bruno Eto, was to see if aqueous extract of Origanum majorana L. may exhibit an effect on those deleterious mechanisms. The effect of aqueous extract of Origanum majorana on electrogenic Cl- secretion and Na+ absorption, the two main mechanisms underlying water movement in the intestine, was assessed on intestinal pieces of mice intestine mounted, in vitro, in Ussing chambers. aqueous extract of Origanum majorana effect on muscle relaxation was measured on rat intestinal smooth muscle mounted in an isotonic transducer.

  1. Aqueous extract of Origanum majorana placed on the serosal (i.e. blood) side of the piece of jejunum entirely inhibited in a concentration-dependent manner the Forskolin-induced electrogenic chloride secretion, with an IC50 = 654 ± 8 µg/mL
  2. Aqueous extract of Origanum majorana placed on the mucosal (i.e. luminal) side stimulated in a concentration-dependent manner an electrogenic Na+ absorption, with an IC50 = 476.9 ± 1 µg/mL.
  3. Aqueous extract of Origanum majorana (1 mg/mL) inhibition of Forskolin-induced electrogenic secretion was almost entirely prevented by prior exposure to Ca++ channels or neurotransmitters inhibitors.
  4. Aqueous extract of Origanum majorana (1 mg/mL) proabsorptive effect was greater in the ileum and progressively declined in the jejunum, distal colon and proximal colon (minimal).
  5. Aqueous extract of Origanum majorana inhibited in a concentration-dependent manner smooth muscle Carbachol or KCl induced contraction, with an IC50 = 1.64 ± 0.2 mg/mL or 1.92 ± 0.8 mg/mL, respectively. The present results indicate that aqueous extract of Origanum majorana L. exhibit positive cooperative effects on the main mechanisms that are involved in acute infectious diarrhea.

Cardiovascular Diseases (CVD):

Marjoram can be a helpful natural remedy for people at high risk or suffering from high blood pressure symptoms and heart problems. It’s naturally high in antioxidants, making it excellent for the cardiovascular system as well as the whole body. Marjoram can also be of great benefit to the heart and entire circulatory system by extension, thanks to its abundance of antioxidant nutrients. These nutrients help to reduce the impact of oxidative and inflammatory processes on these critical structures so that atherosclerosis does not occur at an accelerated speed. Its calming nature also means that it can assist with hyperspastic states of the heart when a reduction in pulse may be desired. It should come as no surprise that natives in regions where Marjoram grows abundantly also have relatively lower rates of cardiovascular illness when compared to the worldwide average.

Inhaling Marjoram oil can help decrease blood pressure and relax the cardiovascular system. Inhale it directly from the bottle, use with an essential oil necklace, or try adding several drops of the oil to a bath for an ultimate relaxing experience. The inhalation of Marjoram essential oil has actually been shown to lower sympathetic nervous system activity and stimulate the parasympathetic nervous system, resulting in vasodilatation to reduce cardiac strain and decrease blood pressure.

An animal study published in Cardiovascular Toxicology found that sweet Marjoram extract worked as an antioxidant and inhibited the production of nitric oxide and lipid peroxidation in myocardial infarcted (heart attack) rats. By simply smelling the plant, you can decrease your "fight-or-flight" response (sympathetic nervous system) and increase your “rest and digest system” (parasympathetic nervous system), which lessens the strain on your entire cardiovascular system, not to mention your whole body.

High Blood Pressure (Hypertension):

High blood pressure is known to cause extra strain on the heart and if not kept in check can lead to a variety of heart related problems. Marjoram is highly rich in potassium, which is very beneficial to keep our blood pressure under control. Potassium acts as a vasodilator, which means it reduce the strain from the blood vessels and provide smooth passage of blood through arteries, thus helps in reduce the blood pressure. Apart from this Marjoram also contain diuretic nature, which mean it helps to promote the urination, thus release of excess water from our body will help to reduce our blood pressure. As a result, excess water, salts and toxins are flushed out of the system.

Marjoram is able to lower sympathetic nervous system activity and stimulate the parasympathetic nervous system, resulting in vasodilatation, which in turn may reduce cardiac strain and decrease blood pressure. Chronic stress increases the flight or fight response and cortisol levels. Marjoram oil can decrease your stress response and increase your relaxation response (parasympathetic nervous system). Marjoram oil is beneficial to reduce both systolic and diastolic blood pressure and heart rate by relaxing the nervous system. Aromatherapy massage with Marjoram oil also relaxes and calms the emotions.

Studies have found that Marjoram is effective in lowering blood pressure without affecting the heart rate. This also helps in lowering blood pressure. Inhaling essential oils, including Marjoram, was able to help reduce blood pressure in people with hypertension and pre-hypertension.

Simply inhaling Marjoram essential oil can lower stress levels and stimulate the parasympathetic nervous system. When the body is in a relaxed and restful state, any strain on the cardiovascular system is greatly lessened and blood pressure is naturally reduced.

Cholesterol Levels:

A 2015 study "Modulatory effect of Origanum majorana extract against cisplatin-induced dyslipidemia in rats" published in International Journal of Current Research in Life Sciences, Vol 4, No 6 by Amany Ahmed Sayed, Shreen Desouky, Mohamed Marzouk, Amel M Soliman, evaluated the curative effect of Origanum majorana ethanolic extract on the lipid profile abnormalities induced by cisplatin in a male Wistar rat model. There was a decrease in total lipid, triglycerides, and LDL cholesterol together with an increase in HDL. Results showed a hypolipidemic potential against cisplatin induced dyslipidemia and suggests that Origanum majorana might serve as a novel adjuvant therapy with cisplatin.

Coronary Artery Diseases:

Coronary artery diseases are the major causes of disabilities and death worldwide.

A 2021 study "Origanum majorana L. Extract Protects Against Isoproterenol-Induced Cardiotoxicity in Rats" published in Cardiovasc Toxicol. by Abeer M Rababa'h, Miya A Alzoubi, evidence from the literature has demonstrated that Origanum majorana L. (Marjoram) acts as an antioxidant, anti-inflammatory, antiplatelet, and assists in hormonal regulation. However, there is limited scientific evidence describing the signaling pathways associated with the Marjoram's positive effect on cardiac injury. Therefore, we aimed to understand the mechanistic protective effects of Marjoram on isoproterenol (ISO)-induced myocardial injury in rats. Sprague Dawley rats were randomly assigned into six groups. Marjoram was administrated by oral gavage and isoproterenol was administrated subcutaneously (ISO; 85 mg/kg). Heart weight, cardiac enzymes, inflammatory, and oxidative stress biomarkers were measured. The ISO-induced cardiac injury was confirmed by the significant increase in the levels of cardiac enzymes (P value < 0.05), whereas pre-treatment with Marjoram normalized these cardiac injury parameters. We also determined that Marjoram had a protective effect against ISO-induced increase in C-reactive protein (CRP), IL-6, IL-13, and TNF-α. Additionally, Marjoram significantly decreased cardiac thiobarbituric acid reactive substances (TBARS) levels (P value < 0.05) and protected against ISO-induced oxidative stress. We have demonstrated that Marjoram decreased both cardiac oxidative stress and inflammation, thus establishing the beneficial effects of Marjoram on ISO-induced cardiac injury in rats.

Hematologic Diseases:

Blood Circulation:

Certain spices and herbs are known for their ability to improve our blood circulation. Marjoram is one such herb. Compounds and minerals found in Marjoram oil are known to help the blood move more freely. Better circulation can have a relieving effect on chronic joint inflammation such as arthritis. It can also be beneficial for anyone suffering from flu-like symptoms as it removes excess mucus. Marjoram is rich rich in iron which both helps in blood production and blood circulation. Vasodilators cause widening of blood vessels to accommodate larger blood volumes. Its diuretic properties also contribute to blood pressure management as flushing of excess fluid via the kidneys lends itself to favorable blood volume. The consumption of Marjoram ensures that your daily requirements of iron are met, which improves blood circulation and the transport of oxygen to all parts of the body. This helps in improving your energy levels and also in optimizing the functioning of various organs in the body.

Blood Clotting:

Marjoram is an excellent source of vitamin K, which is essential for normal blood clotting to take place. Excessive loss of blood is one of the factors leading to anemia and clotting helps prevent heavy bleeding. Marjoram is also high in iron content, another nutrient needed for the production of hemoglobin.

Respiratory Conditions:

Asthma, cold, sinusitis, congestion and similar respiratory infections generally occur due to the invasion of bacteria, virus and other harmful micro-organisms. As a potent expectorant, antimicrobial, antiviral and antibacterial agent along with its power to pacify excess kapha energy responsible for the buildup of phlegm and mucous deposits in the nasal and respiratory passage, Marjoram essential oil is effective in treating various respiratory conditions.

Diffusing Sweet Marjoram essential oil can be particularly effective at reducing chronic coughing and helps to clear excess phlegm and mucus from the throat, chest and sinuses. It is naturally decongestant and can also be diluted with a pure carrier oil and used as a chest rub or dabbed into the temples to help clear stuffy sinuses. 3 drops of Marjoram oil with 2 drops of Eucalyptus oil added to steam inhalation and in your vaporizing ointment, massaged gently on throat, back, chest and temples can help in loosening mucous and phlegm, relieve chest and nasal congestion, alleviate headache related to sinusitis and migraine, treat flu, sore throat and other respiratory problems. Try inhaling the oil directly from the bottle or applying a few drops to the cheeks and under your nostrils.

Cold and Flu:

Marjoram contains various compounds that have effective antibacterial, antiviral and antifungal properties. As such, it can help reduce your risk of diseases such as the common cold, flu, measles, mumps, influenza, food poisoning and various staph infections.

For external use, take Marjoram oil, chop 9 oz (250 g) Marjoram into 1 quart (1 liter) Olive oil. Boil in a double-boiler for an hour, filter it and use to friction painful areas. It is also excellent to treat colds.

Cought:

Marjoram is an age old remedy for treating the coughs. It functions as an expectorant and helps to loosen phlegm and mucus, aiding in its expulsion. The saponin found in this herb has decongestant properties and helps in relieving congestion in the sinuses and chest, providing immense relief. As a result, Marjoram is often used in the treatment of respiratory problems like asthma, sinusitis, bronchitis and coughs.

Tumors & Cancers:

Human Cancer Cell Lines (Cytotoxicity):

A 2016 study "In Vitro Cytotoxic Effect of Aqueous Extract of Origanum marjorana on AMN-3 Cell Line" published in Journal of Natural Sciences Research by Fayhaa M. Khaleel Areej SH. Hameed Taghreed U. Mohammd, evaluated the potential anticancer activity of Origanum majorana aqueous extract from air-dried plant materials on cancer cell lines AMN-3. Results showed growth inhibition of AMN-3 cell line that increased with plant extract concentration. The aqueous extract showed significant cytotoxic effect (p<0.05) with 66% at 100 mg/mL, 53,3% at 50 mg/mL, 40% at 25 mg/mL and decreasing to 0.8% at 0.04 mg/mL concentration.

Chemotherapy:

Despite the fact that cisplatin is an important anticancer drug, its clinical utilization is limited by nephrotoxicity during long term medication. Combined cisplatin chemotherapy with plant extracts can diminish toxicity and enhance the antitumor efficacy of the drug.

A 2016 study "Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress" published in Nutrients by Amel M Soliman, Shreen Desouky, Mohamed Marzouk, Amany A Sayed, evaluated the effect of Originum majorana ethanolic extract (OMEE) on cisplatin-induced nephrotoxicity. Eighteen male rats were divided into three groups as follows: a control group, a group treated with cisplatin (3 mg/kg body weight), and a group that received both cisplatin and OMEE (500 mg/kg body weight) for 14 days. Cisplatin induced a significant increase in creatinine, urea, uric acid, blood urea nitrogen, malondialdehyde, and nitric oxide levels. However, glutathione, superoxide dismutase, and catalase levels were significantly diminished. Conversely, OMEE significantly modulated the renal and oxidative markers negatively impacted by cisplatin. OMEE significantly reduced the effects of cisplatin-induced changes in renal and oxidative markers, possibly through its free radical scavenging activity. Thus, OMEE may be combined with cisplatin to alleviate nephrotoxicity in cancer chemotherapy.

Blood Cancer (Leukemia):

Marjoram essential oil use also reduced the spread of leukemia and caused cell death of leukemia cells in culture. The main component of Marjoram is called Terpinen-4-ol induces a significant growth inhibition of: colorectal cancer, pancreatic cancer, prostate cancer and gastric cancer cells in animal models.

A 2010 study "The apoptotic and anti-proliferative activity of Origanum majorana extracts on human leukemic cell line" published in Leuk Res. by Roula M Abdel-Massih, Rida Fares, Samer Bazzi, Nisrine El-Chami, Elias Baydoun, scientists are constantly searching for phytochemicals and compounds with anti-cancer and antioxidant activity. In this study, the anti-proliferative activity of plant extracts from Origanum majorana was tested on human lymphoblastic leukemia cell line Jurkat. Cytotoxicity was examined using non-radioactive cytotoxicity assay and the IC(50) was calculated. At non-cytotoxic concentrations, the viability of cells decreased with increase of concentration of plant extract. The anti-proliferative effect was also found to be dose-dependent. Analysis via flow cytometry shows that Marjoram extracts stimulated apoptosis. Induction of apoptosis was caused by an up-regulation of p53 protein levels and down-regulation of Bcl-2alpha. Marjoram exhibited a strong scavenging activity (SC(50)=0.03mg dry weight). The conclusions from this study suggest that Marjoram extracts exhibit anti-proliferative effect and high antioxidant activity. For that it merits further investigation as a potential therapeutic agent.

Breast Cancer:

Yusra Al Dhaheri, Samir Attoub, Kholoud Arafat, Synan AbuQamar, Jean Viallet, Alaaeldin Saleh, Hala Al Agha, Ali Eid, Rabah Iratni, in a study "Anti-Metastatic and Anti-Tumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling and Reduction of Nitric Oxide Production" have reported the anticancer activity of Origanum majorana by promoting cell cycle arrest and apoptosis of metastatic MDA-MB-231 breast cancer cell line. This study demonstrated that non-cytotoxic concentrations of O. majorana significantly inhibited the migration and invasion of MDA-MB-231 cells as shown by wound healing and matrigel invasion assay. On chick embryo tumor growth assay, Origanum majorana was shown to promote inhibition of tumor growth and metastasis in vivo. Findings suggest a promising chemopreventive and therapeutic candidate that modulate breast cancer growth and metastasis.

Colon Cancer - Colorectal Cancer:

Colorectal cancer is the third most common type of cancer in terms of incidence and mortality worldwide. Marjoram worked against cancer cells that were resistant to standard treatment in colorectal cancer. Impressively, terpenin-4-ol resulted in 80-90% growth reduction of tumors in cell culture.

A 2020 study "Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells" published in Biomolecules by Khawlah Athamneh, Aysha Alneyadi, Halima Alsamri, Asma Alrashedi, Abdulrasheed Palakott, Khaled A El-Tarabily, Ali H Eid, Yusra Al Dhaheri, Rabah Iratni, investigated the anti-colon cancer potential of Origanum majorana essential oil and its underlying mechanisms of action. We showed that Origanum majorana essential oil significantly inhibited the cellular viability and colony growth of human HT-29 colorectal cancer cells. Origanum majorana essential oil induced protective autophagy, associated with downregulation of the mTOR/p70S6K pathway, and activated caspase-8 and caspase-9-dependent apoptosis. Blockade of autophagy with 3-methyladenine (3-MA) and chloroquine (CQ), two autophagy inhibitors, potentiated the Origanum majorana essential oil-induced apoptotic cell death. Inversely, inhibition of apoptosis with the pan-caspase inhibitor, Z-VAD-FMK, significantly reduced cell death, suggesting that apoptosis represents the main mechanism of Origanum majorana essential oil-induced cell death. Mechanistically, we found that Origanum majorana essential oil induces protective autophagy and apoptotic cells death via the activation of the p38 MAPK signaling pathway. Pharmacological inhibition of p38 MAPK by the p38 inhibitors SB 202190 and SB 203580 not only significantly decreased apoptotic cell death, but also reduced the autophagy level in Origanum majorana essential oil treated HT-29 cells. Strikingly, we found that Origanum majorana essential oil also induces p38 MAPK-mediated caspase-dependent cleavage of p70S6K, a protein reported to be overexpressed in colon cancer and associated with drug resistance. Our findings suggest that Origanum majorana essential oil inhibits colon cancer through p38 MAPK-mediated protective autophagy and apoptosis associated with caspase-dependent cleavage of p70S6K. To the best of our knowledge, this study is the first to report on the implications of the p38 MAPK signaling pathway in targeting p70S6K to caspase cleavage.

A 2015 study published in Master of Science in Molecular Biology and Biotechnology by Nedaa Faisal Al Tamimi from United Arab Emirates University evaluated a Origanum majorana plant extract for anti-cancer effect on in vitro proliferation and DNA damage on human colon cancer HT-29 cell line. Results showed O. majorana inhibited growth of DT-29 cells by affecting cell viability. Extract also showed ability to cause DNA damage, cell cycle arrest and apoptotic death through activation of caspase 8 and 3 pathways. Results showed it is an effective inhibitor of colon cancer progression.

A 2012 study on “Thymus mastichina: chemical constituents and their anti-cancer activity" published in Universidade Nova de Lisboa, Portugal concludes that the cytotoxicity-guided study of the dichloromethane and ethanol extracts of Thymus mastichina, commonly known as Spanish Marjoram, using the HCT colon cancer cell line allowed the identification of nine compounds, sakuranetin, sterubin, oleanolic acid, ursolic acid, lutein, beta-sitosterol, rosmarinic acid, 6-hydroxyluteolin-7-O-beta-glucopyranoside, and 6-hydroxyapigenin-7-O-beta-glucopyranoside.

Lung Cancer:

Current targeted and immuno-therapies have prolonged the overall survival of non-small cell lung cancer (NSCLC) patients by few months in a small percentage of patients responding to these treatments. This situation has prompted us to investigate the anticancer potential of the Origanum majorana Essential Oil.

A 2022 study "Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo" published in Biomed Pharmacother. by Kholoud Arafat, Shahrazad Sulaiman, Aya Mudhafar Al-Azawi, Javed Yasin, Subi Sugathan, Abderrahim Nemmar, Sherif Karam, Samir Attoub, in this pre-clinical study and using two major human NSCLC, namely A549 and LNM35, we demonstrated that Origanum majorana Essential Oil significantly decreases the viability of these cells and the growth of their pre-formed colonies in vitro in a concentration-dependent manner and partly via the induction of caspase 3/7-dependent cell death and downregulation of survivin. Moreover, Origanum majorana Essential Oil significantly slow down the growth of A549 and LNM35 tumor xenografts in the CAM and in nude mice models in vivo. Furthermore, Origanum majorana Essential Oil significantly reduces in vitro A549 and LNM35 cancer cell migration and invasion, and the incidence and growth of lymph nodes metastasis in vivo in nude mice xenografted subcutaneously with the highly metastatic LNM35 cells. Three months of treatment of mice with Origanum majorana Essential Oil did not affect blood, kidney, and liver functions. Our study demonstrates that Origanum majorana Essential Oil is a safe and robust anticancer option.

A 2018 study "Use of Origanum majorana oil in lung cancer therapy" as a Experimental-Molecular Therapeutics, Pharmacogenomics Drug Discovery - Drug Design in ESMD Open Cancer Horizons, Vol 3, Issue Suppl 2 by S Attoub, S Shahrazad, A Kholoud, evaluated the use of Origanum Majorana 100% pure essential oil in lung cancer therapy using two major human cancer cell, i.e., A549 and LNM35. Results showed concentration and time-dependent decrease in viability of lung cancer cells and their related colonies growth in vitro. Treatment also significantly decreased the growth on LNM35 and A549 xenografts in chick embryo and in nude mice models in vivo without significant side effects. Study showed major oil constituents that mediate anti-cancer effects.

A 2013 study "A comparative study of cytotoxic, membrane and DNA damaging effects of Origanum majorana’s essential oil and its oxygenated monoterpene component linalool on parental and epirubicin-resistant H1299 cells" published in Biologia, Vol 68, Issue 4 by Ayse Erdogan, Aysun Ozkan, of essential oil from Origanum majorana and its oxygenated monoterpene component linalool was tested on parental and epirubicin-resistant (drug resistant) human lung cancer cell lines (H1299). Results showed Origanum majorana essential oil and linalool exhibited cytotoxic, membrane and DNA damaging effects. Results suggest further studies for its potential therapeutic application for human lung cancer.

Liver Cancer - Hepatocellular Carcinoma (HCC):

Hepatocellular carcinoma (HCC) is one of the most common cancer types with a high prevalence and itis the leading cause of cancer deaths worldwide. All research using Marjoram in cancer research should be considered preliminary at this point. It looks promising as an add-on for helping the body. For example, Marjoram reduced spread of liver cancer in cell culture.

A 2016 study "The antiproliferative effect of Origanum majorana on human hepatocarcinoma cell line: suppression of NF-κB" published in Cell Mol Biol (Noisy-le-grand) by S A Fathy, M A Emam, S H Abo Agwa, F A Abu Zahra, F S Youssef, R M Sami, aimed to investigate the antiproliferative effect of aqueous and ethanol extracts of Origanum majorana leaf on human hepatocellular carcinoma (HepG2) cell line through incubation of various concentrations of origanum majorana extracts with HepG2 and at different time intervals. The effects of aqueous and ethanol extracts of Origanum majorana L. on HepG2 cell viability, nuclear factor kappa B (NF-kB) gene expression were examined. The results of the cell viability assays showed that aqueous and ethanol extracts exhibited a highly significant inhibitory effect on HepG2 cell proliferation which was evidenced by a reduction in viable cell count. The results were confirmed by microscopical examination of cell morphology. Furthermore, the Origanum majorana L. extracts suppressed the activity of NF-kB gene expression of HepG2 cells compared to the control.The conclusions from this study suggest that Marjoram extracts exhibit anti-proliferative effect against HCC through suppressing the activity of NF-kB gene expression and high antioxidant activity.

Kidney Disorders:

Detox the Body:

Marjoram oil is perspiration, which means induces sweating or sweating. This will keep the body healthy by removing harmful toxins and excess sodium. Fat is also a diuretic and thus increases the amount of urine passed through the body. This helps to remove uric acid, reduce blood pressure, clear kidneys and reduce fat content in the body.

Promotes Urination (Diuretic):

For some people Marjoram essential oil is a great way to regulate their urination. Frequent urination enables us to rid our bodies of unwanted uric acid, excess water, sodium, sugars and various toxic substances. The longer toxic substances remain in the body, the greater the risk that they will do damage. Although it’s not advisable to urinate so frequently that it leads to dehydration, it’s a good practice to keep hydrated enough to keep the kidneys clean.

Shortly after starting to consume Marjoram you are bound to notice one of its most prominent effects- an increased rate or urination. This benefit is actually quite useful, as people with increased urinary outputs are less likely to develop kidney stones as the time waste spends in the bladder and kidneys is reduced. This also means that sedimentation is less likely to happen. Natural diuretics are also useful for helping to manage conditions characterized by larger blood volumes, such as in patients with heart failure. Marjoram, especially its essential oil, can work as a natural diuretic meaning it increases both the quantity of urine you produce and how often you pass water. Diuretics help flush the system of excess water and toxins like excess sodium and uric acid. Diuretics or water pills are often prescribed for urinary tract infections and kidney troubles and can also help you shed excess water weight. You should however always speak to a doctor before trying a natural diuretic treatment as it may cause the body to become dehydrated.

According to researchers, increased urination may also help reduce fat and lower blood pressure. People who take Marjoram to increase urination should increase their water intake in order to prevent dehydration. Regular urination can help.

Increases Sweating:

Urinating is not the only way to rid the body of foreign bodies and compounds we don’t need. Sweating is also a great way of cleansing the skin and blood. That’s why we all feel so good after taking a sauna. Well this oil is known to allow the body to sweat more readily. By sweating more your body can dispose of any nonessential minerals and detox your system even further.

Urinary Tract Infections (UTI):

Urinary tract infections, caused by Escherichia coli 80% to 85% of the time, are one of the most important causes of morbidity and health care spending affecting persons of all ages. These infections lead to many difficult problems, especially increasing resistance to antibiotic drugs. Bacterial biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and relapses.

A 2019 study "Antibacterial and Biofilm Inhibitory Activity of Medicinal Plant Essential Oils Against Escherichia coli Isolated from UTI Patients" published in Molecules by Rihab Lagha, Fethi Ben Abdallah, Badriah Osama Al-Sarhan, Yassin Al-Sodany, investigated the antibacterial activity of five medicinal plant essential oils against UTIs caused by E. coli using disc diffusion and minimal inhibition concentration (MIC) methods. In addition, biofilm inhibitory action of oils was realized by crystal violet. Gas chromatography⁻mass spectrometry (GC⁻MS) analysis showed a variability between oils in terms of compound numbers as well as their percentages. Antibacterial activity was observed only in cases of Origanum majorana, Thymus zygis and Rosmarinus officinalis, while Juniperus communis and Zingiber officinale did not showed any effect towards E. coli isolates. T. zygis essential oil demonstrated the highest antibacterial activity against E. coli isolates, followed by Origanum majorana and Rosmarinus officinalis. Further, oils showed high biofilm inhibitory action with a percentage of inhibition that ranged from 14.94% to 94.75%. Rosmarinus officinalis oil had the highest antibiofilm activity followed by T. zygis and Origanum majorana. Accordingly, tested oils showed very effective antibacterial and antibiofilm activities against E. coli UTIs and can be considered as good alternative for antibiotics substitution.

Kidney Damage:

Antioxidants in Marjoram oil remove harmful radicals from the body. It also prevents lipid peroxidation and detoxify the liver, therefore, protect against oxidative damage and hepatotoxicity. Furthermore, Marjoram oil also prevent kidney cell damage induced by lead toxicity.

A study "Potential chemopreventitive activity of doash, (origanum majorana L.), a Saudi Arabian herbal tea" published in an e-theses Online Service by Khan, Jehan A., evaluated the potential of Doash (Origanum majorana) leaf water extracts for antimutagenic and anticarcinogenic effects against known classes of mutagens. Results showed the tea extract can affect the mutagenicity of various structurally diverse promutagens including food borne carcinogen by decreasing P450-mediated activation. Daily intake of doash tea may protect against the conversion of promutagene to mutagene and scavenging carcinogen from environmental contact.

Mental Health & Behavioural Conditions:

Stress:

Marjoram especially its essential oil is an excellent remedy for relieving feelings of stress and anxiety. The list of great health benefits begins with stress relief. Marjoram essential oil is known to contain compounds that give it a calming effect. The active ingredients within Marjoram offer both the mind and body relief from the stresses of the day. The use of Marjoram oil is popular in aromatherapy because of the relaxes body. In addition to inhaling, rubbing can also be done on foot or body. Many essential oils have a similar impact and represent a great natural alternative to the many popular prescription medications. These sedative and relaxing qualities are being used to handle stress in a natural way.

Post-Traumatic Stress Disorder (PTSD):

Marjoram has an extremely calming effect on the body and can actually promote feelings of happiness, this is why it is a great herb to use for grief, shock and PTSD.

Anxiety and Fear:

Marjoram is classed as a nervine, a herb that strengthens the nervous system and helps to combat anxiety and fear. That is a great reason to add Marjoram essential oil to your collection.

A 2011 study "Comparative Study of Sedative, Pre-Anesthetic and Anti-Anxiety Effect of Origanum majorana Extract with Diazepam on Rats" published in Research Journal of Biological Sciences by Ali Rezaie, Behboud Jafari, Ghafour Mousavi, Mehrdad Nazeri, Amirreza Ebadi, Changiz Ahmadeh, and Elmira Habibi, evaluated the sedative, pre-anesthetic, and anti-anxiety effects of Origanum majorana with diazepam in different groups of male Wistar rats. Results showed sedative and anti-anxiety effects possibly due to the flavonoids present in the extract with its effect on benzodiazepine receptor binding to GABA-A receptors. Origanum majorana extract at dose of 200 mg/kbw was significant compared to diazepam at does of 1.2 mg/kg.

You can either diffuse it around the home and inhale its vapors or dilute it with a carrier oil to make a stress relieving massage. By helping relieve your tensions and anxieties,

Depression:

A 2020 study "Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum majorana L. Polyphenols in Swiss Albino Mice" published in Molecules by Amal Amaghnouje, Hamza Mechchate, Imane Es-Safi, Smahane Boukhira, Ali S Aliqahtani, Omar M Noman, Fahd A Nasr, Raffaele Conte, Anna Calarco, Dalila Bousta, aims to evaluate the antidepressant-like effect of the Origanum majorana L. polyphenols (OMP) obtained from the aerial parts using two different depression model tests: The forced swimming test (FST) and the tail suspension test (TST) in Swiss albino mice. The experiments were performed on days 1, 7, 14, and 21 with daily administration of different treatments. Two different doses were chosen for this study (50 and 100 mg/kg), and paroxetine was used as a positive control. Immobility as a consequence of the depression state was significantly reduced following the treatment with OMP, indicating an antidepressant effect. A subacute toxicity study was also performed following the Organization for Economic Co-operation and Development (OECD) Guidelines (407), showing no sign of toxicity for the studied doses. The phytochemical screening revealed the presence of 12 components, all belonging to polyphenols: Arbutin, rosmarinic acid, ursolic acid, quercetin-3-O-glucoside, quercetin-7-O-glucuronic acid, luteolin-7-O-glucoside, kaempferol-3-0-glucuronic acid, Kaempferol-3-0-pentose, caffeic acid, catechin, quercetin, and rutin. These findings suggest that Origanum majorana has interesting antidepressant-like properties, which deserve further investigation.

Nervous System:

Marjoram, in its essential oil form, can help uplift your mood and improve your psychological well-being. It can be used to help relieve insomnia and reduce stress and anxiety. Since the prehistoric times, Marjoram is trusted to be the herb of happiness and love. You will be amazed if I say that this "Joy of the mountain" was adored for its ability to tone down distress and misery. Robbi Zeck is a pioneer author in the field of the psychological benefits of essential oils and how they affect the integration of emotional experiences. With regards to Marjoram essential oil she has this to say, “Marjoram's warm herbal aroma will strengthen your nervous system, rebuild your reserve, fortify your spirit and reduce obsessive thinking".

Marjoram is one of the few herbs that supports the effective functioning of the nervous system. The nutrients in the herb enhances brain activity and helps prevent damage to the nerve cells. Marjoram essential oil is known to soothe and calm the mind and alleviate disorders like anxiety, stress and depression. It is also used in the treatment of dementia and Alzheimer’s disease. Everything from nervous tension, anxiety, depressed thoughts, negative feelings, loneliness, lack of concentration, stress, mood fluctuations and anger to inferiority complex, has a time to rest with the kind of emotional benefits owned by Marjoram oil.

Pranayama is the Ayurvedic art of balanced breath where the therapeutic properties of these essential oils reach the limbic system of the brain through the aromatic molecules during conscious inhalation of breath or the life force. This renovates the mind and repairs toxicity of the mind and body. In a much similar way, the toxic remains and de-motivating feelings are discarded from the system during extended exhalation.

Practicing Pranayama with 2 drops of Marjoram oil with 2 drops of Rosemary oil and 2 drops of Tangerine oil in a diffuser, can help you significantly in relieving stress, anger, anxiety, hatred thoughts, vengeance, inferior feelings and lower self esteem.

Following this balanced breathing technique daily with the use of Marjoram oil is an excellent way to inculcate optimistic feelings, self-love, self-acceptance, improved concentration, mental dynamism, enhanced memory power and assisting in the treatment of Alzheimer’s disease. This is an effective remedy for protecting the brain from neuronal damages.

Spiritual Benefits:

Marjoram is a representation of tranquility, harmony, health and heartiness. It enlightens the soul by awakening the sense of self-consciousness, especially when using it during meditation. The oil of Marjoram has a positive effect on the heart chakra and the solar plexus chakras, where chakras are the centers of energy in the subtle body. The heart chakra or Anagatha determines one’s ability to love and the emotional factors associated with it are self-love, love for others, inner peace and joy. Solar plexus chakra or Manipuraga decides a person’s level of confidence and the potent to take control of one’s live. Emotional attributes related with this chakra are self-confidence and self-esteem.

Adding 2 drops of Marjoram oil and 2 drops of Vetiver oil added to your burner or diffuser at the time of meditation and prayers can open your eye of consciousness, empower your spirit, foster mental clarity, augment self-love paving way for higher self-esteem and improved self-confidence. A peaceful life with joy and focused living is in store for you to enjoy and enrich.

Neurological Health & Nerve Diseases:

Sharpens Memory:

Marjoram essential oil use has potential to help with memory because it has anticholinesterase activity. You may be familiar with this action because class of drugs uses it to help treat Alzheimer’s disease. High in antioxidants, Marjoram may also protect the brain and reduce inflammation.

Alzheimer’s Disease:

A 2001 study "Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase" by Chung YK, Heo HJ, Kim EK, Kim HK, Huh TL, Lim Y, Kim SK, Shin DH, screened 139 herbal spices in search of acetylcholinesterase (AChE) inhibition. Acetylcholinesterase inhibitors, which enhance cholinergic transmission through reduction of enzymatic degradation of ACh, are the only compounds approved for the treatment of Alzheimer's diseases. Of the edible plants and spices, an ethanol extract of Origanum majorana showed the highest inhibitory effect on AChE in vitro. The urosolic acid of Origanum majorana inhibited AChE activity in a dose dependent and competitive/non-competitive type. Results demonstrated the urosolic acid of Origanum majorana is a potent AChE inhibitor in Alzheimer's disease.

Parkinson's Disease:

A 2021 randomized controlled pilot study "The effect of Origanum majorana tea on motor and non-motor symptoms in patients with idiopathic Parkinson's disease" published in Parkinsonism Relat Disord. by Chbili Chahra, Hassine Anis, Douma Bissene, Selmi Mejda, Maatoug Jihène, Naija Salma, Nouira Manel, Ben Amor Sana, Khairi Hedi, Ben Fredj Maha, was investigated in patients with idiopathic Parkinson's disease, measured by validated tools. 60 patients with idiopathic Parkinson's disease and under conventional medication were enrolled voluntarily in the study. All participants were randomized on double-blind to placebo or Origanum majorana. Clinical assessment with validated tools (UPDRSIII, NMSS, and BDI) was done before Origanum majorana or placebo consumption (Day 0) and at the end of the experiment (Day 30). The treatment groups were similar at baseline on demographic and clinical variables. During the course of study, nine participants withdrew for reasons of noncompliance and inability to follow-up. 51 participants completed the study. Upon completion of 30 days of treatment, Origanum majorana tea consumption did not decrease the UPDRSIII score ([UPDRSIII] D0 = 18.76 ± 8.58, D30 = 16.52 ± 7.96, p = 0.069) at the p value was 0.07. However, a statistically significant improvement was noted in NMSS and BDI scores (p < 0.0001 and p < 0.0001, respectively). Assessment of the UPDRSIII, NMSS and BDI scores of the patients did not reflect any improvement with placebo. No side effect was detected during the study. These findings show improvement of depressive and non-motor signs in patients with Parkinson's disease in the group that consumed Origanum majorana tea in combination with conventional therapy. Improvement of motor signs may need an extended treatment period. However, more research with a large number of participants and lasting longer than 1 month is needed to argue these findings.

Sleep Disorders:

Improves Sleep:

Do you regularly have difficulty getting or staying asleep? If so, then maybe you would be well served by chowing down on some Marjoram leaves before bed. Ok, maybe not that drastic, but you do stand to benefit handsomely from ensuring that you do consume more over the course of the day. As the Marjoram oil contains linalyl acetate is known for its calming effect. Linalool stables the cardiovascular system and relaxes the body. Monoterpenes which has anti-inflammatory and antibacterial properties. Terpinen-4-ol helps in dilating blood vessels and regulate the nervous system.

A combination of Marjoram oil (2%) and dilute it with Almond oil (5 ml) massage is very effective to improve sleep quality. Alternatively, you can also diffuse Marjoram essential oil around your home to initiate the process of unwinding, or apply locally to your upper torso for a soothing massage to get to sleep. If you are looking for a safe natural choice to help you sleep, choose Marjoram.

Insomnia:

A vast majority of people around the world suffer from insomnia, the inability to fall asleep or stay asleep. Good quality sleep is absolutely critical for maintaining a healthy body and mind. Marjoram essential oil is a wonderful remedy for people with insomnia, as it has the ability to soothe and calm the mind. It can release your mind off of stress and tension and provide a sedative effect. With strong sedative qualities, the essential oil can be diffused in the bedroom to create a warming, nurturing atmosphere that is conducive to a good night’s sleep. The calming properties of Marjoram oil will are soothing, helping to relax your mind and rest easily.

To make a Marjoram infusion, take 1½ oz (40 grams) of fresh leaves and flowers (ten times less if dried) for 1 quart (1 liter) water. Steep for 10 minutes and drink 3 to 4 mugs a day between meals, and another before sleeping in case of insomnia. You can also diffuse 3-4 drops Marjoram in your favorite diffuser at bedtime. A few drops of Marjoram essential oil on the pillow is all you need to drift off into a good night’s sleep.

If muscular soreness and tension is preventing you from sleeping, a night time massage or bath using the essential oil can soothe away aches and pains whilst promoting a relaxed state of mind.

Prevents Snoring:

Snoring can affect the quality of your sleep. Marjoram and the essential oil extracted from Marjoram helps to prevent snoring by improving the respiratory system and relaxing your larynx. The excellent aroma of Marjoram spreads through your body and clears your air passages.

Take around 10 drops of Lavender essential oil and 10 drops of Marjoram essential oil in a small glass bottle. You can either add it to essential oil vaporizer and place it in the bedroom an hour before sleeping or simply sniff it before bed.

Women's Health Issues:

Marjoram has long been valued in women’s health. It can help to restore the balance of female hormones and to regulate menstruation. Not only does it help regulate the cycle but it also helps to relieve many of the familiar symptoms that women get during their monthly period and can also help treat the symptoms associated with menopause. For women dealing with hormone imbalance, this herb may finally help you maintain normal and healthy hormone levels. Whether you’re dealing with the unwanted monthly symptoms of PMS or menopause, this herb can provide relief for women of all ages. It’s been shown to act as an emmenagogue, which means it can be used to help start menstruation. Because of its natural emmenagogue properties, it can stimulate menstruation and has even been used to help nursing mothers produce more milk.

Menstrual Cramps (Dysmenorrhea):

A 2012 randomized Controlled double-blind clinical trial "Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea" published in Journal Obstet Gynaecol Res. by Ming-Chiu Ou, Tsung-Fu Hsu, Andrew C Lai, Yu-Ting Lin, Chia-Ching Lin, assessed the effectiveness of blended essential oils on menstrual cramps for outpatients with primary dysmenorrhea and explored the analgesic ingredients in the essential oils. A randomized, double-blind clinical trial was conducted. 48 outpatients were diagnosed with primary dysmenorrhea by a gynecologist and had 10-point numeric rating scales that were more than 5. The patients were randomly assigned to an essential oil group (n = 24) and a synthetic fragrance group (n = 24). Essential oils blended with Lavender (Lavandula officinalis), Clary Sage (Salvia sclarea) and Marjoram (Origanum majorana) in a 2:1:1 ratio was diluted in unscented cream at 3% concentration for the essential oil group. All outpatients used the cream daily to massage their lower abdomen from the end of the last menstruation continuing to the beginning of the next menstruation. Both the numeric rating scale and the verbal rating scale significantly decreased (P < 0.001) after one menstrual cycle intervention in the two groups. The duration of pain was significantly reduced from 2.4 to 1.8 days after aromatherapy intervention in the essential oil group. Aromatic oil massage provided relief for outpatients with primary dysmenorrhea and reduced the duration of menstrual pain in the essential oil group. The blended essential oils contain four key analgesic components that amount to as much as 79.29%; these analgesic constitutes are linalyl acetate, linalool, eucalyptol, and β-caryophyllene. This study suggests that this blended formula can serve as a reference for alternative and complementary medicine on primary dysmenorrhea.

Menstrual Cycle (Amenorrhea):

Marjoram has been shown to stimulate menstrual flow. Its extract or tea may help regulate your menstrual cycle, as well as restore hormone balance in non-pregnant women with an irregular cycle. Marjoram has circulatory, sedative, relaxant and emmenagogue properties that help in regulating the menstrual cycle in case of missed periods or delayed menstruation, reduce menstrual pain and fortify the pelvic muscles. To avoid risks, check with your healthcare provider before taking any herbal supplements to aid menstruation.

Hormonal Balance:

Marjoram is known in traditional medicine for its ability to restore hormonal balance and regulate the menstrual cycle. For women dealing with hormone imbalance, this herb may finally help you maintain normal and healthy hormone levels. Whether you’re dealing with the unwanted monthly symptoms of PMS or menopause, this herb can provide relief for women of all ages. It’s been shown to act as an emmenagogue, which means it can be used to help start menstruation. It’s also been used traditionally by nursing moms to promote breast milk production. Owing to these properties it is referred to as an emmenagogue, or a natural product that stimulates menstruation. It also shows great potential in helping women deal with symptoms of PMS, and even older women who may be going through menopause. Its extract or tea may help regulate your menstrual cycle, as well as restore hormone balance in non-pregnant women with an irregular cycle. Marjoram essential oil use may also extend to menstrual pain because it has analgesic effects and reduces a hormone precursor called DHEA-S.

Polycystic Ovarian Syndrome (PCOS):

Polycystic ovarian syndrome (PCOS) and infertility are other significant hormonal imbalance issues that this herb has been shown to improve. The tea improved insulin sensitivity and reduced the levels of adrenal androgens in these women. This is very significant since an excess of androgens is at the root of hormone imbalance for many women of reproductive age.

In traditional medicine, Marjoram herb is locally reputed for its ability to restore hormonal balance and to regulate the menstrual cycle. Therefore, a pilot study aimed to investigate the effects of Marjoram tea on the hormonal profile of women with polycystic ovary syndrome in a randomised, double-blind, placebo-controlled trial.

A 2016 A randomized, double-blind, placebo- controlled clinical trial "The effect of Marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome" published in Journal of Human Nutrition and Dietetics by I Hai-Husein, S Tukan, F Alkazaleh, evaluated the effect of Marjoram tea on hormonal profile of women with polycystic ovary syndrome measuring parameters of FSH, LH, progesterone, estradiol, total testosterone, DHEA-S, fasting insulin and glucose, and homeostasis model assessment for insulin resistance (NOMA-IR) and glucose to insulin ratio. Results showed beneficial effects of majoram tea on hormonal profile of PCOS women as suggested by improved insulin sensitivity and reduced levels of adrenal androgens. Study evaluated the effects of Marjoram tea on the hormonal profile of women with PCOS in a randomized, double-blind, placebo controlled trial. Results showed beneficial effects of Marjoram tea on the hormonal profile of PCOS women evidenced by improvement in insulin sensitivity and reduction of levels of adrenal androgens. The study’s results revealed the positive effects of the tea on the hormonal profile of PCOS women. The tea improved insulin sensitivity and reduced the levels of adrenal androgens in these women. This is very significant since an excess of androgens is at the root of hormone imbalance for many women of reproductive age.  The study’s results revealed the positive effects of the tea on the hormonal profile of PCOS women.

The same study concluded as “the beneficial effects of Marjoram tea on the hormonal profile of PCOS women because it was found to improve insulin sensitivity and reduce the levels of adrenal androgens".

A 2015 randomised controlled pilot trial "The effect of Marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome" published in Journal Hum Nutr Diet. by Haj-Husein, S Tukan, F Alkazaleh, 25 patients were assigned to receive Marjoram tea or a placebo tea twice daily for 1 month (intervention group: n = 14; placebo group: n = 11). The hormonal and metabolic parameters measured at baseline, as well as after the intervention, were: follicle-stimulating hormone, luteinising hormone, progesterone, oestradiol, total testosterone, dehydroepiandrosterone-sulphate (DHEA-S), fasting insulin and glucose, homeostasis model assessment for insulin resistance (HOMA-IR) and glucose to insulin ratio. Marjoram tea significantly reduced DHEA-S and fasting insulin levels (P < 0.05) by a mean (SD) of 1.4 (0.5) μmol L(-1) and 1.9 (0.8) μU mL(-1) , respectively. In comparison to the placebo group, the change was only significant for DHEA-S (P = 0.05) but not for insulin (P = 0.08). HOMA-IR was not reduced significantly in the intervention group (P = 0.06), although the change was significant compared to the placebo group (P < 0.05). The results obtained in the present study show the beneficial effects of Marjoram tea on the hormonal profile of PCOS women because it was found to improve insulin sensitivity and reduce the levels of adrenal androgens. Further research is needed to confirm these results and to investigate the active components and mechanisms contributing to such potential beneficial effects of Marjoram herb.

Massaging the lower abdomen, lower back and thighs with 5 drops of Marjoram oil, 5 drops of Thyme oil and 4 oz of Sesame oil can aid in stimulating regular menstruation, lessen pain, fatigue and anxiety associated with periods and check polycystic ovarian syndrome with its power to reinstate hormonal balances and considerably decrease the level of adrenal androgens.

Men's Health Issues:

Male Fertility Issues:

Marjoram oil may help treat male fertility issues, as well. Research has shown a positive relationship between sperm count as well as an overall increase in testicular structure with the use of Marjoram essential oil.

Sexual Health:

Sexual Desire:

Marjoram essential oil is known for inhibiting sexual desires and is an anaphrodisiac (the opposite of an aphrodisiac). While this may not seem like a benefit at first glance, it definitely is one. It can help you control and suppress sexual desires and it really comes in handy if you have some extremely desires or abnormal ones. While everyone is entitled to do as they please in the bedroom, it is important to curb desires that can hurt you or others around you.

Antioxidants:

A 2022 review "Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal" published in Molecules by Prem Narayan Paudel, Prabodh Satyal, Rakesh Satyal, William N Setzer, Rajendra Gyawali, was conducted to examine the chemical constituents of Origanum majorana L. essential oils that originate in Nepal, as well as their biological activities, antioxidant properties, and enantiomeric compositions. The essential oils were extracted by the hydro-distillation method using a Clevenger-type apparatus and their chemical compositions were determined through gas chromatography and mass spectrometry (GC-MS). Chiral GC-MS was used to evaluate the enantiomeric compositions of essential oils. The minimum inhibitory concentrations (MICs) of the essential oils were determined by the micro-broth dilution method, and the antioxidant activity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl scavenging assay and ferric-reducing antioxidant power (FRAP). GC-MS analysis showed the presence of 50 and 41 compounds in the essential oil samples, (S1) and (S2), respectively, representing the Kathmandu and Bhaktapur districts. The oxygenated monoterpenoids, along with terpinen-4-ol, were predominant constituents in both essential oil samples. However, the essential oils from two locations showed some variations in their major components. The chiral terpenoids for two essential oil samples of Marjoram have also been reported in this study in an elaborative way for the first time in accordance with the literature review. A hierarchical cluster analysis based on the compositions of essential oils with 50 compositions reported in the literature revealed at least 5 different chemotypes of Marjoram oil. The antioxidant activity for the sample (S2) was found to be relatively moderate, with an IC50 value of 225.61 ± 0.05 μg/mL and an EC50 value of 372.72 ± 0.84 µg/mL, as compared to the standard used. Furthermore, with an MIC value of 78.1 µg/mL, the essential oil from sample (S2) demonstrated effective antifungal activity against Aspergillus niger and Candida albicans. Moreover, both samples displayed considerable antimicrobial activity. The results suggest that essential oils of Origanum majorana possess some noteworthy antimicrobial properties as well as antioxidant activity, and hence can be used as a natural preservative ingredient in the food and pharmaceutical industries.

A 2019 study "Antioxidant potency and GC-MS composition of Origanum majorana Linn" published in Pak J Pharm Sci. by Nyayiru Kannaian Udaya Prakash, Nannu Shankar Sripriya, Dinakaran Divakar Raj, Santhanakrishnan Deepa, Srinivasan Bhuvaneswari, the methanolic extract of the leaves of Origanum majorana L., was screened for its antioxidant potential and chemical composition. Apart from high total phenolic, flavonoid and antioxidant contents, significant free radical scavenging ability was observed as assessed by the free radical scavenging assays viz., 2,2-Diphenyl-1-picryl hydrazyl, Ferric thiocyanate, Thiobarbituric acid, Ferric reducing antioxidant power and ABTS assays. The GC-MS analysis of the methanolic extract detected the presence of seven compounds - 5H-Cyclopropa [3,4] benz [1,2-e]azulen-5-one, 3,9,9a-tris (acetyloxy) - 3 - [(acetyloxy) methyl] - 2 - chloro - 1, 1a, 1b, 2, 3, 4, 4a, 7a, 7b, 8, 9, 9a-dodecahydro-4a,7b-dihydroxy - 1, 1, 6, 8-tetrame - thyl -, [1aR (1aa,1ba, 2a, 3a, 4aa, 7aa, 7ba, 8a, 9a, 9aa)]-; Pentacosanoic acid, methyl ester; 10-Octadecenoic acid, methyl ester; 1, 2, 4-Trioxolane-2-octanoic acid, 5-Octyl-, methyl ester; Oleoyl chloride; Docosanedioic acid, dimethyl ester and Ethyl iso-allocholate.

A 2018 study "Antineurodegenerative, antioxidant and antibacterial activities and phenolic components of Origanum majorana extracts" published in Journal of Applied Botany and Food Quality by Sonja Duletić-Laušević, Ana Alimpić Aradski, Stoimir Kolarević, Branka Vuković-Gačić, Mariana Oalđe, Jelena Živković, Katarina Šavikin, Petar D. Marin, showed high amount of rosmarinic acid, especially in the ethanolic extract. In this study, the water and ethanolic extract showed promising natural sources of bioactive compounds. The aqueous extract showed better antioxidant, antimicrobial, and antineurodegenerative activity than ethanolic extracts.
 

A 2015 study published in Indian Journal of Natural Products and Resources by Prernaa and Neeru Vasudeva, of ethanol extract of leaves showed antioxidant and marked free radical-scavenging activity using DPPH assay. Ethanol extracts of both stem and root showed in vitro antioxidant activity using DPPH, H2O2 free radical scavenging assay, metal chelating, and ferric reducing power assay. IC50s were comparable to ascorbic acid.

Another 2014 study published in American Journal of Drug Discovery and Development by Neeru Vasudeva, Prerna Singla, Sneha Das, and Surendra Kumar Sharma, investigated ethanol extracts of stem and root of Origanum majorana for antigout and antioxidant activity in rat models. Both ethanol extracts showed potent antioxidant activity in all models (DPPH, H2O2 radical scavenging, metal chelating). In vitro xanthine oxidase inhibitory activity was significant for both stem and root extracts with IC50s of 59.21 and 148 µg/ml, respectively. The extracts showed significant decrease in uric acid, creatinine, ESR, and MDA in the gouty rats. Results showed significant antigout activity associated with both antioxidant and anti-inflammatory effects which may be due to the presence of flavonoids, phenolics, saponins, and triterpenoidal compounds.

Free Radicals:

Antioxidants help prevent cell damage caused by potentially harmful molecules called free radicals. Several compounds in Marjoram, such as carvacrol, have been shown to have antioxidant effects. In particular, they may help reduce inflammation in your body. Marjoram has strong antioxidant activity as well.

A 2011 study "Free radical scavenging and antiacetylcholinesterase activities of Origanum majorana L. essential oil" published in Hum Exp Toxicol. by A T H Mossa, G A M Nawwar, Origanum majorana L. essential oil (EO) was analyzed by gas chromatography-mass spectrometry (GC-MS) and evaluated for free radical scavenging and anticholinesterase activities. GC-MS analysis revealed the presence of 4-terpineol (29.97%), γ-terpinene (15.40%), trans-sabinene hydrate (10.93), α-terpinene (6.86%), 3-cycolohexene-1-1 methanal,a,a4-trimethyl-,(S)-(CAS) (6.54%), and sabinene (3.91%) as main constituents. Origanum majorana L. essential oil exhibited concentration-dependent inhibitory effects on 2,2'-diphenylpicrylhydrazyl (DPPH(•)), hydroxyl radical, hydrogen peroxide, reducing power, and lipid peroxidation with IC(50) values of 58.67, 67.11, 91.25, 78.67, and 68.75 µg/mL, respectively; while the IC(50) values for the standard trolox were noted to be 23.95, 44.97, 51.30, 42.22, and 52.72 µg/mL, respectively. Interestingly, cholinesterase inhibitory activity was also found with IC(50) values of 36.40 µg/mL. We can conclude that the Marjoram essential oil has a significant potential to be used as a natural antioxidant and anti-AChE.

Pain & Inflammation:

Relieves Pain:

Perhaps this is why Aphrodite used Marjoram essential oil as a love potion. Marjoram oil induces relaxation, and the induction of a relaxed state of mind certainly makes it easier to fall in love. And when you’re relaxed, you’re less likely to experience pain to the same extent as you would if you’re tense.

It is effective against most pains, including ones that are connected to fevers, colds, headaches, toothaches, exertion of the muscles, inflammation, and calming properties of it can be felt in both body and mind. Marjoram offers decent pain relief by modulating inflammatory processes, making it useful for dealing with minor aches and pains. The anti-inflammatory and calming effects of Marjoram essential oil work to reduce pain associated with muscle tightness, muscle spasms and tension headaches. With its power to eliminate fluid retention, toxic substances, salts, fat deposits and uric acid in the system, Marjoram is a proven remedy for treating edema, rheumatic and arthritic conditions where inflammation, redness, pain, soreness and swelling of joints are witnessed. This makes it an extremely good substance to manage your pain and it comes with the additional benefit of being herbal, unlike other over the counter drugs that are available in the market. People choose this chemical-free Marjoram oil over painkillers, especially when they need to make use of them on a regular basis.

Inhaling the oil or using it as a massage lotion can calm the nervous system, lower blood pressure and provide pain relief. You may be best served by applying locally after making into a paste or by using the essential oil, or you can consume a bit of the leaves. Alternatively, soak in a Marjoram essential oil bath to relieve pain and promote relaxation.

A study published in Complementary Therapies in Medicine indicates that when Sweet Marjoram aromatherapy was used by nurses as part of patient care, it was able to reduce pain.

In a collective study of over 10,000 hospital admissions, Marjoram essential oil use reduced pain the most of any essential oils and also significantly reduced anxiety. A blend of essential oils including Marjoram was able to reduce menstrual pain and reduce the need for pain medications. In a nursing home setting, use of a blend of essential oils, including Marjoram, dramatically reduced pain and symptoms of depression in people with arthritis.

Massaging the affected parts with 5 drops of Marjoram oil along with 3 drops of Cedarwood oil with 2 ounce of Coconut oil can assist in relieving pain, swelling, muscular soreness, lumbago, joint aches and other associated discomforts by discarding excess toxins in the form of sweat and urine. For relaxation purposes, you can try diffusing it in your home and using it in your homemade massage oil or lotion recipe.

Relieves Spasms:

A spasm is an involuntary flexing of the muscle. Spasms can affect different bodily systems as well as our limbs. Marjoram essential oil is known for curing spasms as well. It is highly effective against spasms that occur in the respiratory and digestive tract. It can even help with muscular spasms that occur in the limbs. One of the great active ingredients of Marjoram essential oil has antispasmodic properties. Taken regularly, Marjoram can protect against and lower the risk of spasms.

You can use Marjoram oil to cure problems like convulsions, spasmodic cholera, cramps, and pulled muscles. It is, therefore, a great oil to have in your home if you are used to regular physical exertion.

Reduces Inflammation:

While inflammation is a normal bodily response, chronic inflammation can increase your risk of certain diseases, including diabetes, cancer, and autoimmune disorders. Thus, reducing inflammation may lower your risk. In addition to having antioxidant properties, most of the nutrients in Marjoram also has anti-inflammatory effects. When taken internally, added to food, this herb is effective in treating ailments caused by inflammation such as fever, asthma, muscle aches, sinus headaches, migraines etc.

Marjoram can be applied topically to get relief from toothache, headache, sore joints, arthritis and many other inflammatory conditions. Marjoram essential oil use is also anti-inflammatory in cell culture against lipid-reactive compounds (lipopolysaccharides). With its power to eliminate fluid retention, toxic substances, salts, fat deposits and uric acid in the system, Marjoram is a proven remedy for treating edema, rheumatic and arthritic conditions where inflammation, redness, pain, soreness and swelling of joints are witnessed.

Bone & Muscle Related Disorders:

Strengthens Bones:

Marjoram is an effective herb that helps to improve the health of your bones and tissues connected to the bones. Regular intake of Marjoram is a great way to boost the strength and health of your bones. This amazing herb provides about 520% of the recommended daily intake of vitamin K, a nutrient that contributes to the development of healthy bones. Vitamin K also plays a key role in building bone mass by promoting osteotrophic activity in the bones, so Marjoram is an effective remedy to increase the bone density Moreover, it helps to prevent fractures and helps to increase the speed of the healing process.

Joint and Muscle Pain:

As well as treating emotional pain, Marjoram essential oil is an excellent remedy for muscle and joint pain. You can use Marjoram oil to cure problems like convulsions, spasmodic cholera, cramps, and pulled muscles. It is, therefore, a great oil to have in your home if you are used to regular physical exertion. With its mild sedative, analgesic and antispasmodic properties, Marjoram essential oil relieves pain in the muscles and joints. Marjoram oil is also a perfect oil to add to a soothing massage blend for targeting tired and stressed muscles and joints. Anyone can clearly pinpoint Marjoram essential oil for relaxing tensed muscles, especially after workouts or physical exertion. With its mild sedative, analgesic and antispasmodic properties, Marjoram essential oil relieves pain in the muscles and joints.

Combine a few drops of Marjoram with a carrier oil and massage it into the affected parts of your body for instantaneous relief. You could also add 3 or 4 drops of your oil to the bathtub and let it soak over your body.

For joint relief, blend: 8 drops of Marjoram oil, 10 drops Siberian Fir and 10 drops of Lemongrass. For muscle pain, add also 6 drops of Frankincense essential oil. Combine the blend below in a 10 ml roller bottle and top with FCO. Roll on areas of concern as needed.

Common Eye Disorders & Diseases (CDC):

Improves Eyesight:

Two of the most important antioxidants in Marjoram are lutein and zeaxanthin, which are known to contribute to healthy vision and are found in the macula of the eye, the part responsible for colour and clarity. It is believed that these antioxidants can also play a role in limiting the risk of macular degeneration, although further research needs to be conducted before conclusions can be made.

Oral Diseases:

Bruxism (Teeth Grinding):

A 2019 study "Origanum majorana Essential Oil Inhalation during Neurofeedback Training Reduces Saliva Myeloperoxidase Activity at Session-1 in Bruxistic Patients" published in Journal of Clinical Medicine by José Joaquín Merino, José María Parmigiani-Izquierdo, María Elvira López-Oliva and María Eugenia Cabaña-Muñoz, evaluated whether Saliva myeloperoxidase activity could be reduced after 21 neurofeedback training sessions in bruxistic Origanum majorana-treated patients. Results showed that activity could predict stress level in bruxistic patients and repeated neurofeedback training reduced their stress level. Origanum majorana essential oil enhanced these anxiolytic effects.

Root Canal Infection:

A 2017 study "Origanum majorana L. as an Herbal Medicine for the Treatment of Apical Abscess: A Case Report and Literature Review" published in Galen Medical Journal by Maryam Mosaffa-Jahromi, Maryam Firouzmandi, Mehdi Pasalar, reports on a 28-year old female who presented with a preapical abscess which resolved after two days of an herbal preparation of Origanum majorana, without surgical intervention or post-treatment complication. Results suggest potential for a complementary or alternative non-invasive treatment for dental problems.

Immune Diseases:

Boosts Immune System:

Marjoram is an immunity booster because of the presence of nutrients like vitamin A and vitamin C, both of which also acts as strong antioxidants. Vitamin C strengthens the immune system by increasing the number of white blood cells, which protects the body against the attack of foreign invaders like bacteria and virus.

According to studies, vitamin A also plays an important role in supporting the healthy functioning of the immune system.

Speeds up Healing Process:

Marjoram is exceptionally useful for helping you recover from the common cold, regardless of if yours was caused by a bacteria or virus. In addition to its antimicrobial properties, Marjoram also exhibits expectorant actions to loosen mucus and promote its removal. Addition that to the bronchodilatory and decongestant effects and you have an invaluable aide against the common cold.

Antimutagenic Activity:

A 2013 study "Antimutagenic effect of Origanum majorana L. essential oil against prallethrin-induced genotoxic damage in rat bone marrow cells" published in Journal Med Food by Abdel-Tawab H Mossa, Amel A Refaie, Amal Ramadan, Jalloul Bouajila, aimed to investigate the genotoxic and cytotoxic potential of prallethrin in rat bone marrow cells and the protective effect of Origanum majorana L. essential oil. Our results demonstrated that prallethrin at dose 64.0 mg/kg body weight (b.wt.) (1/10 LD50), has a clastogenic/genotoxic potential as shown by the high percentage of chromosomal aberration (CA) and micronucleus (MN) in the bone marrow cells of male rats, whereas the combined treatment of prallethrin and Origanum majorana essential oil resulted in the reduction of the CA (54.54%). The combined treatment also reduced the micronuclei formation significantly. In conclusion, prallethrin can be considered clastogenic/genotoxic and may carry a risk to human health. The study revealed the antigenotoxic and anticytotoxic potential of Origanum majorana essential oil against prallethrin-induced genotoxic and cytotoxic effects in rat bone marrow cells.

Diabetes Mellitus:

Diabetes is an ever-growing health problem with modern lifestyles. Nearly 10% of the population alone of the United States have diabetes and there are no signs that the figure is slowing down. Fortunately, type 2 diabetes can be managed with good lifestyle choices and diet. Herbs like Marjoram are proving very useful to help with this expensive disease. Insulin resistance is a root cause of many issues with diabetes. Marjoram tea consumed twice daily was able to improve insulin sensitivity. Marjoram essential oil use was able help a protein involved in insulin production called dipeptidyl peptidase IV in a cell study. New classes of expensive drugs also have this action to help treat diabetes. You may have heard of these drugs; they are very expensive. They include: Januvia (Sitagliptin), Galvus (Vildagliptin), Onglyza (Saxagliptin), Tradjenta (Linagliptin) While Marjoram essential oil use is looking promising for diabetes, it hasn’t been studied in combination with medications at this time.

Studies have shown that Marjoram is a plant that belongs in your anti-diabetes arsenal and something you should definitely include in your diabetic diet plan.

A 2012 study "Comparative antihyperglycaemic and antihyperlipidemic effect of Origanum majorana extracts in NIDDM rats" pubslihed in Pharm Exp Med by B. P. Pimple, P. V. Kadam, M. J. Patil, in streptozotocin-induced diabetic rats showed the volatile oil and methanolic extract of leaves of Origanum majorana could be beneficial in the management of NIDDM and its associated lipid imbalance.

Another in Evidence-Based Complementary and Alternative Medicine, Volume 2012 published study "Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro and in Streptozotocin-Induced Diabetic Rats" by Rosa Martha Perez Gutierrez, about the development of AGE (advanced glycation end products) inhibitors is considered to have therapeutic potential in diabetic patients. Study investigated the effect of methanoic extract of leaves of O. majorana on AGEs formation. Treatment of STZ-induced diabetic mice with OM and glibenclamide for 28 days showed beneficial effects on renal metabolic abnormalities including glucose level and AGEs formation. OM alleviated oxidative stress under diabetic conditions through inhibition of lipid peroxidation, preventing and/or delaying the onset of renal damage. Specifically, researchers found that commercial dried varieties of this plant, along with Mexican Oregano and Rosemary, act as a superior inhibitor of the enzyme known as protein tyrosine phosphatase 1B (PTP1B). In addition, greenhouse-grown Marjoram, Mexican oregano and rosemary extracts were the best inhibitors of dipeptidyl peptidase IV (DPP-IV). This is an awesome finding since the reduction or elimination of PTP1B and DPP-IV helps improve insulin signaling and tolerance. Both fresh and dried Marjoram can help improve the body’s ability to properly manage blood sugar.

Blood Sugar:

If you have been diagnosed as a type 2 diabetic, you are in luck, as Marjoram is here to offer you much needed assistance with your blood glucose levels. Marjoram, Oregano and Rosemary contain specific enzymes which contribute to improved blood glucose readings since their actions are said to help improve insulin sensitivity. Development of insulin resistance is a major hurdle diabetics face and which often worsen their prognosis of the condition. These herbs effectively inhibit certain enzymes which improve insulin tolerance. Whether you eat the herb fresh or dried, it can be a great help to a diabetic patient’s ability to manage their blood sugar levels.

Skin & Hair Condition and Care:

Skin Care:

You may have noticed that some of the skincare products such as lotions, skin creams and soaps contain Marjoram. This is because Marjoram is good for your skin. The antioxidants in Marjoram help protect your skin from harmful free radicals. It also delays your skin from having fine lines and wrinkles which are signs of premature aging  and when used regularly can leave you looking younger and healthier. Marjoram is a natural antiseptic and is hence used as a remedy for various skin conditions such as acne, pimples, rashes, psoriasis and eczema. The antiseptic properties of this herb also makes it effective in treating wounds and in preventing infection. Marjoram also exhibits anti-fungal properties, which helps in preventing fungal infections such as athlete’s foot and jock itch.

The application of a mixture of Marjoram essential oil and olive or Coconut oil is a great way to prevent the occurrence of premature signs of aging such as wrinkles, dark spots and fine lines.

Skin Disorders:

Marjoram essential oil has antimicrobial, antifungal, antiseptic and disinfectant properties that make it an effective oil in healing wounds, rashes, dermatitis, scalp infections, invasion of microbes causing skin infections and acne.

Recent studies have established the high concentration of linalool component in Marjoram oil, which contributes to the anti-inflammatory, antiseptic and antifungal properties, thus making it as a significant oil in various cosmetics and skin care products.

Blend 2 drops of Marjoram oil with 1 drop of Rosemary oil, 1 drop of Ylang Ylang oil and 1 drop of Orange oil and mix it with your mild skin care lotion or cream and lightly dab it on the affected areas for treating acne, dermatitis, sunburn, shaving irritation, wounds (for fighting against micro-organisms like Staphylococcus bacteria, which worsens infections in case of wounds or other skin problems) and wrinkles. You can also mix this blend in your bath for treating inflamed scalp conditions and for refreshing your skin health.

Skin Aging (Wrinkles):

Marjoram is a rich source of various nutrients that exhibits powerful antioxidant effects. One of the main factors that cause early aging is the oxidation of cells brought about by free radicals in the body. Antioxidants helps in protecting your cells and DNA from the damage caused by these free radicals. The intake of foods rich in antioxidants such as Marjoram is thus helpful in maintaining good health and youth. They fight against free radicals and stabilize them to do the oxidative damage to our healthy cells, thus the main cause of macular degeneration of our skin cells and age related skin problem such as wrinkle, dark spots, etc.

Studies have been proven that consumption of Marjoram on a regular basis can reduce the age related problem and keeps us young.

Hair Care:

Marjoram essential oil in your hair and scalp will strengthen your hair follicles. It’ll promote stronger and healthier hair growth. Because of its antifungal and antibacterial properties, it’s also a good treatment for your dandruff problems and itchy scalp. Marjoram tea and oil are often used in hair rinses to revitalize the hair and to impart a nice and pleasant aroma to the hair. Marjoram essential oil can strengthen the follicles meaning your hair should grow back stronger and healthier. It nourishes the hair follicles, softens and strengthens the hair, prevents hair damage and also prevent various scalp infections. Marjoram is known to darken the hair and so the rinse can be used to darken graying hair. The oil also contains anti-fungal properties which makes it a good natural option to treat common scalp issues like dandruff. It also smells great so give it a try.

You can add a few drops of Marjoram essential oil to your regular conditioners or shampoo to help strengthen your hair and enhance its appearance.

Head Lice:

It really is time to ditch store-brand head lice chemical treatments. Not only are they harmful, they really don’t work. Marjoram essential oil was able to even kill drug-resistant head lice at a rate of 100% at the highest concentration. Marjoram essential oil use naturally repels and kills them.

Pet Health:

Feed Hens:

A 2021 study "Productive Performance, Ovarian Follicular Development, Lipid Peroxidation, Antioxidative Status, and Egg Quality in Laying Hens Fed Diets Supplemented with Salvia officinalis and Origanum majorana Powder Levels" published in Animals (Basel) by Ahmed A Saleh, Shimaa Hamed, Aziza M Hassan, Khairy Amber, Wael Awad, Mohammed H Alzawqari, Mustafa Shukry, aimed to assess the effect of dietary supplementation with different levels of Salvia officinalis and/or Origanum majorana on productive performance, ovarian follicular development, lipid peroxidation, antioxidative status, and egg quality in laying hens. Two hundred and ninety-four 45-week-old Bovans brown hens were allocated into seven groups, with seven replicates of six hens each. The first group was fed with the basal considered as a control (A); the second (B) and third (C) groups were provided with the same control diet further supplemented with 0.5 and 1 kg/ton Salvia officinalis, respectively; the fourth (D) and fifth (E) groups received the control diet further supplemented with 0.5 and 1 kg/ton Origanum majorana, respectively; while the sixth (F) and the seventh (G) groups were offered a diet supplemented with 0.5 kg/ton Salvia officinalis and 0.5 kg/ton Origanum majorana and 1 kg/ton Salvia officinalis and 1 kg/ton Origanum majorana, respectively. No significant effects were observed in the final body weight (BW) and feed intake (FI) of the laying hens. In the diets supplemented with Salvia officinalis and Origanum majorana, the egg weights for groups C, F, and G had significantly higher values only compared to group D. The supplementation of the diets with Salvia officinalis and/or Origanum majorana significantly (p < 0.05) increased the Follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol estrogenic hormone concentration, except for Origanum majorana at both levels with regard to estradiol. The dietary utilization of Salvia officinalis and Origanum majorana did not significantly alter the plasma glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), total protein, albumin, globulin, and High density lipoprotein (HDL) parameters. Cholesterol, glucose, triglyceride, and Low density lipoprotein (LDL) were decreased (p < 0.05) in the birds fed with Salvia officinalis and/or Origanum majorana supplemented diets. Moreover, at both doses, the dietary supplementation with Salvia officinalis and Origanum majorana decreased (p < 0.05) the yolk cholesterol and liver Malondialdehyde (MDA) levels. In addition, the dietary enrichment with Salvia officinalis and/or Origanum majorana decreased (p < 0.05) the palmitoleic and stearic fatty acids' egg yolk concentration. In contrast, the yolk linoleic fatty acid concentration was significantly increased by Salvia officinalis and/or Origanum majorana. In conclusion, dietary supplementation with Salvia officinalis and/or Origanum positively affected productive performance, ovarian follicular development, antioxidant activity, hormonal status, and steroidogenesis in Bovans brown laying hens.

Infected Chicken (Eimeria tenella):

A 2021 study "Anticoccidial effect of Origanum majoranum aqueous extract on Eimeria tenella-infected chicken" published in Trop Biomed by E R A Mohamed, M F Elazab, N El-Habashi, N Elhawary, A A Mokhbatly, Avian coccidiosis, an important protozoal disease of chicken triggered by coccidian protozoa of genus Eimeria, causes considerable economic losses to broiler producers. The study was designed to assess the efficiency of Origanum majoranum aqueous extract on E. tenella-infected broiler chicken. Birds were divided into four groups including: positive control (PC, challenged with 5×104 sporulated oocysts of E. tenella at the 12th day of age), PC+Origanum majoranum aqueous extract (challenged with E. tenella oocysts at the 12th day of age and received Origanum majoranum aqueous extract (125 mg/kg BW) orally, started at the 7th day of age, and continued for 14 consecutive days), Origanum majoranum aqueous extract (received Origanum majoranum aqueous extract (125 mg/kg BW) orally, at the 7th day of age, for 14 consecutive days), and negative control (received basal diet only). Anticoccidial efficacy of Origanum majoranum aqueous extract was evaluated by complete blood picture, serum chemistry, serum protein electrophoresis, antioxidants markers, cecal oocysts count, and cecal lesions score. Briefly, collected data indicated that supplementation of OMAE could increase antioxidants concentrations and improve changes in hematobiochemical parameters and serum protein fractions, as well as decrease cecal oocysts count and reduce cecal lesion scores in E. tenella-infected birds. In conclusion, Origanum majoranum aqueous extract restores oxidant-antioxidant balance, and its supplementation in broiler chicken can alleviate E. tenella-infection and reduce its severity.

Insects & Pests:

In a 2013 study "Amelioration of Prallethrin-Induced Oxidative Stress and Hepatotoxicity in Rat by the Administration of Origanum majorana Essential Oil" published in BioMed Research International by Abdel-Tawab H. Mossa, Amel A. Refaie, Amal Ramadan, and Jalloul Bouajila, synthetic pyrethroids are a new major class of broad-spectrum insecticides. Pyrethroid insecticides are acute neutoxicants and prallethrein is the most popular Type 1 synthetic pyrethroid used for household insect pests such as mosquitoes, houseflies, and cockroaches. Prallethrin has been shown to cause oxidative damage and liver injury in male rats. Study evaluated the protective role of Origanum majorana essential oil against the adverse effects of exposure to prallethrine on oxidant/antioxidant status and liver dysfunction biomarkers in a rat model. Results showed co-administration of essential oil attenuated the toxic effect of prallethrin.

Repels Aedes aegypti Mosquitoes (Dengue):

A 2020 study "Evaluation of larvicidal potential against larvae of Aedes aegypti (Linnaeus, 1762) and of the antimicrobial activity of essential oil obtained from the leaves of Origanum majorana L" published in PLoS One by Renata do Socorro Barbosa Chaves, Rosany Lopes Martins, Alex Bruno Lobato Rodrigues, Érica de Menezes Rabelo, Ana Luzia Ferreira Farias, Lethicia Barreto Brandão, Lizandra Lima Santos, Allan Kardec Ribeiro Galardo, Sheylla Susan Moreira da Silva de Almeida, evaluated the larvicidal activity of Origanum majorana Linnaeus essential oil, identified the chemical composition, evaluated the antimicrobial, cytotoxic and antioxidant potential. The larvicidal activity was evaluated against larvae of the third stage of Aedes aegypti Linaeus, whereas the chemical composition was identified by gas chromatography coupled to mass spectrometer, the antimicrobial activity was carried out against the bacteria Pseudomonas aeruginosa, Escherichia coli and Staphylococcus auereus, the antioxidant activity was evaluated from of 2.2-diphenyl-1-picryl-hydrazila sequestration and Artemia salina Leach cytotoxicity. Regarding to the results, the larvicidal activity showed that O. majorana L. essential oil caused high mortality in A. aegypti L. larvae. In the chromatographic analysis, the main component found in O. majorana L. essential oil was pulegone (57.05%), followed by the other components verbenone (16.92%), trans-p-menthan-2-one (8.57%), iso-menthone (5.58%), piperitone (2.83%), 3-octanol (2.35%) and isopulegol (1.47%). The antimicrobial activity showed that E. coli and P. aeruginosa bacteria were more sensitive to oil than S. aureus, which was resistant at all concentrations. Essential oil did not present antioxidant activity, but it has high cytotoxic activity against A. salina L.

Repels Pediculus humanuscapitis Head Lice:

A 2014 study "Insecticidal activities of sweet marjoram (Origanum majorana L.) against Pediculus humanuscapitis (Anoplura: Pediculidae)" published in International Journal of Current Microbiology and Applied Sciences by Gehad T. El- Sherbini, Eman T. El-Sherbini and Nancy Osman Hanykamel, evaluated the in vitro insecticidal activity of various sweet marjoram extracts against head lice, Pediculus humanus capitis. On the basis of LT50s, marjoram oils were more toxic than either &phenothrin and pyrethrum. In fumigation tests, marjoram oils were more effective in closed containers than in open ones, suggesting the effect was the result of action in the vapor phase. Neither &phenothrin nor pyrethrum exhibited fumigant toxicity.

Another 2004 study "Insecticidal activity of plant essential oils against Pediculus humanus capitis (Anoplura: Pediculidae)" published in Journal Med Entomol. by Yang YC, Lee HS, Clark JM, Ahn YJ., evaluated the insecticidal activity of 54 plant essential oils against female Pediculus humanus capitis using direct contact and fumigation methods, compared with two commonly used pediculicides delta-phenothrin and pyrethrum. In fumigation tests at 0.25 mg/cm2, marjoram, together with three other herbs, were more effective in closed containers. Neither delta-phenothrin nor pyrethrum exhibited fumigant toxicity.

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